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21.发明授权
公开(公告)号：EP0914437B1
公开(公告)日：2006-05-31
申请号：EP97925109.7
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
IPC分类号： C12N15/31 , G01N33/569 , C07K14/35 , C07K16/12 , A61K39/04
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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22.发明公开
公开(公告)号：EP1292333A1
公开(公告)日：2003-03-19
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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23.发明公开LIVE ATTENUATED BORDETELLA STRAINS AS A SINGLE DOSE VACCINE AGAINST WHOOPING COUGH 审中-公开LEBENDEABGESCHWÄCHTEBORDETELLASTÄMMEALS EINZELDOSISIMPFSTOFF GEGEN KEUCHHUSTEN
公开(公告)号：EP3045529A1
公开(公告)日：2016-07-20
申请号：EP16155296.3
申请日：2007-03-07
摘要： A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
摘要翻译： 提供了至少包含突变的ptx基因，缺失或突变的dnt基因和异源ampG基因的突变的博德氏菌菌株。 减毒的突变型博德特氏菌属菌株可用于免疫原性组合物或用于治疗或预防博德氏杆菌感染的疫苗。 还提供了减毒的博德特氏菌属菌株用于制造疫苗或免疫原性组合物的用途，以及用于保护哺乳动物免受博德特氏菌感染的方法。
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24.发明授权ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422B1
公开(公告)日：2011-08-31
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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25.发明公开COMPOSES A EFFET POTENTIALISATEUR DE L'ACTIVITE DE L'ETHIONAMIDE ET LEURS APPLICATIONS 审中-公开CONNECTIONS补强效果ON ethionamide药物及其使用的活性
公开(公告)号：EP2044064A1
公开(公告)日：2009-04-08
申请号：EP07803843.7
申请日：2007-07-04
申请人： INSTITUT PASTEUR DE LILLE , Centre National de la Recherche Scientifique , Université de Lille 2 Droit et Santé , INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： DEPREZ, Benoît , WILLAND, Nicolas , DIRIE, Bertrand , TOTO, Patrick , VILLERET, Vincent , LOCHT, Camille , BAULARD, Alain
IPC分类号： C07D413/14 , C07D413/12 , C07D413/10 , A61K31/4725 , A61K31/496
CPC分类号： C07D413/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to the use of compounds having a potentiating effect on the activity of antibiotics activatable via the EthA enzymatic pathway, for the preparation of a medicament for use in preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to the pharmaceutical compositions containing them in combination with an antibiotic activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics activatable via the EthA enzymatic pathway, to the pharmaceutical compositions containing them and to their use as a medicament, in particular a medicament for use in preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.
摘要翻译： 本发明涉及的化合物的用途与对抗生素的活性的增强作用并是经由ETHA酶途径活化，用于预防和/或治疗分枝杆菌感染的药物中的制备：如结核病和麻风病，药物组合物 在抗生素包含它们结合并经由ETHA途径活化的，涉及一种具有对抗生素并是经由ETHA酶途径活化的活性的增强作用，以药物组合物包含它们的化合物和它们作为药物，爱尤其药物用于使用 预防和/或治疗分枝杆菌感染：如结核病和麻风病。
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公开(公告)号：EP0941241B1
公开(公告)日：2008-08-06
申请号：EP97944948.5
申请日：1997-10-09
发明人： MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
IPC分类号： C07K14/235 , C07K19/00 , A61K38/16
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
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27.发明公开ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422A2
公开(公告)日：2004-08-18
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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28.发明授权
公开(公告)号：EP0755447B1
公开(公告)日：2003-07-02
申请号：EP95918030.8
申请日：1995-04-19
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
IPC分类号： C12N15/31 , C12N15/62 , C07K14/235 , C12N1/21 , A61K39/10
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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公开(公告)号：EP3045529B1
公开(公告)日：2020-07-29
申请号：EP16155296.3
申请日：2007-03-07
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30.发明授权LIVE ATTENUATED BORDETELLA STRAINS AS A SINGLE DOSE VACCINE AGAINST WHOOPING COUGH 有权活的减毒百日咳菌单次剂量百日咳疫苗
公开(公告)号：EP1994139B1
公开(公告)日：2016-07-13
申请号：EP07711815.6
申请日：2007-03-07
CPC分类号： A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/543
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