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21.发明公开DC-89 compounds and process for their preparation 失效DC-89-Verbindungen und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0351865A2
公开(公告)日：1990-01-24
申请号：EP89113431.4
申请日：1989-07-21
发明人： Takahashi, Keiichi , Ichimura, Michio , Katsumata, Shigeo , Ogawa, Tatsuhiro , Morimoto, Makoto , Ashizawa, Tadashi , Kasai, Masaji , Muroi, Kenichi , Saito, Hiromitsu , Sano, Hiroshi , Yasuzawa, Toru
IPC分类号： C07D487/04 , C07D471/04 , A61K31/40 , A61K31/435 , C12P17/18
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel DC-89 compounds represented by the general formula:
wherein X represents a single bond or -CH₂-; and when X represents a single bond, Y represents -CH₂Br or -CH₂Cl and when X represents -CH₂-, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.摘要翻译： 由通式表示的新型DC-89化合物：其中X表示单键或-CH 2 - ; 当X表示单键时，Y表示-CH 2 Br或-CH 2 Cl，X表示-CH 2 - ，Y表示Br时，由本发明得到。 该化合物具有抗菌和抗肿瘤活性。
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22.发明公开KS-506 compounds and process for the production thereof 失效KS-506 Verbindungen und Verfahren zu deren Herstellung。
公开(公告)号：EP0335386A1
公开(公告)日：1989-10-04
申请号：EP89105611.1
申请日：1989-03-30
发明人： Kuroda, Kazutoshi , Kase, Hiroshi , Ando, Katsuhiko , Kawamoto, Isao , Yasuzawa, Toru , Sano, Hiroshi , Goto, Joji , Yamada, Koji
IPC分类号： C07C323/22 , C07C327/16 , C07C69/90 , A61K35/74 , C12P1/04 , C12P7/00 , C12P11/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella .
摘要翻译： 通过培养属于被孢霉属属的微生物产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：EP0228700B1
公开(公告)日：1989-07-19
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
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公开(公告)号：EP0228700A1
公开(公告)日：1987-07-15
申请号：EP86117994.3
申请日：1986-12-23
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Yamashita, Yoshinori , Kawamoto, Isao , Ando, Katsuhiko , Sano, Hiroshi , Yasuzawa, Toru , Shuto, Katsuichi
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCYl003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities:
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公开(公告)号：EP0145023A3
公开(公告)日：1986-01-22
申请号：EP84115350
申请日：1984-12-13
发明人： Omura, Satoshi , Sano, Hiroshi , Yamashita, Kinya , Okachi, Ryo
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： 3, 3", 4"-Tri-O-acylspiramycin I represented by the formula:
wherein R 1 , R 2 and R 3 are the same or different groups, and at least one of the groups is a straight or branched chain alkylcarbonyl group represented by -COC m H 2m+1 wherein m is an integer of 2-4 and the other group(s) are straight or branched chain alkylcarbonyl group(s) represented by -COC n H 2n-1 wherein n is an integer of 1-4, and its pharmacologically acceptable acid addition salts.摘要翻译： 3，3“，4” - 三-O-酰基曲霉素I：其中R1，R2和R3是相同或不同的基团，并且至少一个基团是由下式表示的直链或支链烷基羰基： COCmH2m + 1其中m是2-4的整数，其它基团是由-COCnH2n-1表示的直链或支链烷基羰基，其中n是1-4的整数，并且其药理学上可接受的酸 加成盐。
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公开(公告)号：EP0145023A2
公开(公告)日：1985-06-19
申请号：EP84115350.5
申请日：1984-12-13
发明人： Omura, Satoshi , Sano, Hiroshi , Yamashita, Kinya , Okachi, Ryo
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： 3, 3", 4"-Tri-O-acylspiramycin I represented by the formula:
wherein R 1 , R 2 and R 3 are the same or different groups, and at least one of the groups is a straight or branched chain alkylcarbonyl group represented by -COC m H 2m+1 wherein m is an integer of 2-4 and the other group(s) are straight or branched chain alkylcarbonyl group(s) represented by -COC n H 2n-1 wherein n is an integer of 1-4, and its pharmacologically acceptable acid addition salts.摘要翻译： 3，3“，4” - 三-O-酰基曲霉素I：其中R1，R2和R3是相同或不同的基团，并且至少一个基团是由下式表示的直链或支链烷基羰基： COCmH2m + 1其中m是2-4的整数，其它基团是由-COCnH2n-1表示的直链或支链烷基羰基，其中n是1-4的整数，并且其药理学上可接受的酸 加成盐。
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