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    CLEANING OF A BONE WORKPIECE BY PULSATILE PRESSURE
    22.
    发明公开
    CLEANING OF A BONE WORKPIECE BY PULSATILE PRESSURE 审中-公开
    CLEANING骨的工件，脉动

    公开(公告)号：EP1253949A1

    公开(公告)日：2002-11-06

    申请号：EP01909046.3

    申请日：2001-02-09

    申请人： Osteotech, Inc.,

    发明人： MORRIS, John, W. ,  SHIMP, Lawrence, A. ,  RUSSELL, James ,  SCARBOROUGH, Nelson, L.

    IPC分类号： A61L2/00

    CPC分类号： A61L2/0005 ,  A61L2/0088

    摘要： There is provided a pulsatile flow pressure system for treating tissue, such as, for example, bone tissue. This system generally includes one, and preferably two, pressure chambers configured to receive the natural ends of intact bone. Alternate positive and negative pressures are enacted on the bone ends to force fluid into the bone and substantially out through an exterior surface thereof. Alternatively, both ends of an intact bone can be positioned in separate pressure chambers and simultaneous positive or negative pressures applied to the bone ends to force fluid through the bone tissue.

    BONE MATRIX COMPOSITIONS AND METHODS
    26.
    发明公开
    BONE MATRIX COMPOSITIONS AND METHODS 有权
    KNOCHENMATRIXZUSAMMENSETZUNGEN UND VERFAHREN

    公开(公告)号：EP2167147A2

    公开(公告)日：2010-03-31

    申请号：EP08771191.7

    申请日：2008-06-16

    申请人： Osteotech, Inc.,

    发明人： BEHNAM, Keyvan ,  WEI, Guobao ,  FORSYTH, Nanette ,  BOYCE, Todd, M. ,  SHIMP, Lawrence, A.

    IPC分类号： A61L27/36

    CPC分类号： A61K35/00 ,  A61F2/28 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61K35/32 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/3834 ,  A61L27/54 ,  A61L2430/02 ,  A61L2430/40

    摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

    摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及​​胞吐作用或内吞诱导活性。 在一个实施方案中，用于生产骨诱导性组合物的方法包括提供部分去矿物质的骨，处理部分去矿物质的骨以破坏骨的胶原结构，以及任选地提供组织衍生的提取物，并将组织衍生的提取物加入到部分脱矿质 骨。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分去矿物质的骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。