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21.发明公开
公开(公告)号：EP1435779A2
公开(公告)日：2004-07-14
申请号：EP02766356.6
申请日：2002-09-24
CPC分类号： C12N15/85 , A61K35/12 , C07H21/04 , C12N5/0606 , C12N15/62 , C12N15/63 , C12N2501/40 , C12N2503/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
摘要： Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
摘要翻译： 公开了使用一种或多种ZFP修饰干细胞的方法和组合物。 这些方法和组合物可用于促进诸如分化细胞，将干细胞分化成所需表型，增殖干细胞和/或促进克隆的过程。
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公开(公告)号：EP1276860A2
公开(公告)日：2003-01-22
申请号：EP01929084.0
申请日：2001-04-27
发明人： WOLFFE, Alan , URNOV, Fyodor , GUSCHIN, Dmitry , COLLINGWOOD, Trevor , LI, Xiao-Yong , JOHNSTONE, Brian
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28 , C12Q2531/113 , C12Q2525/191 , C12Q2522/101
摘要： Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
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公开(公告)号：EP2352369B1
公开(公告)日：2017-04-26
申请号：EP09830727.5
申请日：2009-12-03
发明人： CUI, Xiaoxia , GEURTS, Aron M. , URNOV, Fyodor
IPC分类号： A01K67/027 , C12N15/11 , C12N9/22 , C12N15/85
CPC分类号： C12N15/907 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/054 , A01K2217/15 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/1024 , C12N15/8509 , C12N2015/8527 , C12N2800/80
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24.发明授权ENGINEERED ZINC FINGER PROTEINS TARGETING 5-ENOLPYRUVYL SHIKIMATE-3-PHOSPHATE SYNTHASE GENES 有权技术设计为与基因锌指蛋白FOR 5-烯醇丙酮莽草酸-3-磷酸合酶作为目的地
公开(公告)号：EP2205749B1
公开(公告)日：2016-05-18
申请号：EP08833882.7
申请日：2008-09-25
CPC分类号： C12N15/8213 , C07K2319/00 , C07K2319/81 , C12N9/1092 , C12N15/8243 , C12N15/8274
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公开(公告)号：EP2188384B1
公开(公告)日：2015-07-15
申请号：EP08833432.1
申请日：2008-09-25
发明人： DOYON, Yannick , URNOV, Fyodor
IPC分类号： C12Q1/34 , G01N33/573
CPC分类号： C12Q1/6897 , C12N9/22 , C12Q1/34 , G01N33/573 , G01N2333/922
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26.发明公开
公开(公告)号：EP2844754A1
公开(公告)日：2015-03-11
申请号：EP13784528.5
申请日：2013-05-02
发明人： SHUKLA, Vipula , GUPTA, Manju , URNOV, Fyodor , GUSCHIN, Dmitry , JAN DE BOTH, Michiel , BUNDOCK, Paul , SASTRY-DENT, Lakshmi
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
摘要翻译： 本文公开了用于一种或多种内源性植物苹果酸脱氢酶基因的靶向修饰的方法和组合物。
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公开(公告)号：EP2571512A1
公开(公告)日：2013-03-27
申请号：EP11783865.6
申请日：2011-05-17
发明人： GREGORY, Philip, D. , MILLER, Jeffrey, C. , PASCHON, David , REBAR, Edward, J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
IPC分类号： A61K38/16
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译： 本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合域）的细胞和生物体的多肽，多核苷酸。 还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。
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公开(公告)号：EP2419511A1
公开(公告)日：2012-02-22
申请号：EP10761996.7
申请日：2010-04-08
发明人： GREGORY, Philip, D. , HOCKEMEYER, Dirk , HOLMES, Michael C. , JAENISH, Rudolf , SOLDNER, Frank , URNOV, Fyodor , YAO, Shuyuan
CPC分类号： C12N15/86 , C12N9/22 , C12N2710/10343 , C12N2740/15043 , C12N2800/30 , C12N2830/008
摘要： Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells.
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公开(公告)号：EP2352369A1
公开(公告)日：2011-08-10
申请号：EP09830727.5
申请日：2009-12-03
发明人： CUI, Xiaoxia , GEURTS, Aron M. , URNOV, Fyodor
IPC分类号： A01K67/027 , C12N15/11
CPC分类号： C12N15/907 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/054 , A01K2217/15 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/1024 , C12N15/8509 , C12N2015/8527 , C12N2800/80
摘要： Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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公开(公告)号：EP1276860B1
公开(公告)日：2007-09-26
申请号：EP01929084.0
申请日：2001-04-27
发明人： WOLFFE, Alan , URNOV, Fyodor
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28 , C12Q2531/113 , C12Q2525/191 , C12Q2522/101
摘要： Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
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