公开(公告)号：EP1556480B1

公开(公告)日：2011-04-20

申请号：EP03794035.0

申请日：2003-09-03

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： KUSHMARO, Ariel ,  GERESH, Shimona

IPC分类号： C12Q1/24 ,  C12Q1/02 ,  C12Q1/04 ,  C12N1/00 ,  C12N1/20

CPC分类号： C12N1/00

摘要： The invention provides a method for isolating and culturing a previously unculturable microorganism, which comprises: (i) collecting a sample from an environmental source; (ii) counting/estimating the number of microorganisms in the sample; (iii) diluting the sample in an appropriate medium; (iv) adding a gelating agent such as to entrap one or more microorganisms within a sphere of the gelating agent; (v) coating the spheres containing the entrapped microorganism(s) with a natural or synthetic polymer to form a polymeric membrane; (vi) incubating the coated spheres in the original environment for an appropriate time; (vii) cutting the spheres and scanning for microorganisms colonies; and (viii) isolating the microorganisms, and repeating steps (iii) to (vii) until a pure clone of said previously unculturable microorganism is obtained.

公开(公告)号：EP2275121A3

公开(公告)日：2011-04-13

申请号：EP10011321.6

申请日：2003-04-01

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： Mizrachi Nebenzahl, Yaffa

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K39/02 ,  C07K1/00

CPC分类号： A61K39/092 ,  Y10S530/825

摘要： The present invention relates to a vaccine composition comprising as an active ingredient an effective amount of an isolated S. pneumoniae NADH oxidase protein (NOX, Accession No. NP_345923), optionally together with one or more pharmaceutically acceptable adjuvant(s).

公开(公告)号：EP2275127A3

公开(公告)日：2011-03-23

申请号：EP10011327.3

申请日：2003-04-01

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K39/02 ,  C07K1/00

CPC分类号： A61K39/092 ,  Y10S530/825

摘要： The invention relates to a vaccine composition comprising as an active ingredient an effective amount of an isolated S. pneumoniae aspartate carbamoyltransferase catalytic subunit (AC, Accession No. NP_345741), optionally together with one or more pharmaceutically acceptable adjuvant(s).

摘要翻译： 本发明涉及疫苗组合物，其包含作为活性成分的有效量的分离的肺炎链球菌天冬氨酸氨甲酰基转移酶催化亚基（AC，登录号NP_345741），任选与一种或多种药学上可接受的佐剂一起。

公开(公告)号：EP2275120A2

公开(公告)日：2011-01-19

申请号：EP10011320.8

申请日：2003-04-01

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K39/02 ,  C07K1/00

CPC分类号： A61K39/092 ,  Y10S530/825

摘要： The present invention relates to a vaccine composition comprising as an active ingredient an effective amount of an isolated S. pneumoniae glutamyl-tRNA synthetase protein (GtS, Accession No. NP_346492), optionally together with one or more pharmaceutically acceptable adjuvant(s).

摘要翻译： 本发明涉及疫苗组合物，其包含有效量的分离的肺炎链球菌谷氨酰-tRNA合成酶蛋白（GtS，登录号NP_346492），任选地与一种或多种药学上可接受的佐剂一起作为活性成分。

公开(公告)号：EP1957349B1

公开(公告)日：2010-10-06

申请号：EP06809884.7

申请日：2006-11-20

申请人： Ariel-University Research and Development Company Ltd. ,  Ben Gurion University of the Negev Research and Development Authority

发明人： SHRAGA, Shoval ,  SHAPIRO, Amir

IPC分类号： B62D55/065 ,  B62D59/04 ,  B25J5/00

CPC分类号： B62D55/0655 ,  B25J5/005 ,  B62D59/04

公开(公告)号：EP2152663A2

公开(公告)日：2010-02-17

申请号：EP08763505.8

申请日：2008-06-03

申请人： Ben-gurion University Of The Negev Research And Development Authority

发明人： PRIEL, Esther ,  GAZIT, Aviv ,  SLAVIN, Shimon ,  YITZCHAK, Sara

IPC分类号： C07C215/48

CPC分类号： C07C215/80 ,  A61K31/03 ,  A61K31/05 ,  A61K31/055 ,  A61K31/136 ,  A61K31/66 ,  A61K31/695 ,  C07C39/367 ,  C07C43/225 ,  C07C43/23 ,  C07C215/50 ,  C07D213/16 ,  C07D213/30 ,  C07D295/096 ,  C07D295/135 ,  C07F9/5022

摘要： The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.

公开(公告)号：EP1691915B1

公开(公告)日：2010-02-17

申请号：EP04801596.0

申请日：2004-12-07

申请人： BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

发明人： GILRON, Jack ,  KORIN, Eliyahu

IPC分类号： B01D61/10 ,  B01D61/12 ,  B01D65/08 ,  C02F1/44

CPC分类号： B01D61/58 ,  B01D61/02 ,  B01D61/025 ,  B01D61/027 ,  B01D61/10 ,  B01D61/12 ,  B01D61/147 ,  B01D61/364 ,  B01D61/422 ,  B01D65/08 ,  B01D2321/2083 ,  C02F1/441

摘要： A process is provided for purifying water containing soluble species capable of forming one or more sparingly soluble salts or minerals, comprising feeding a pressurized water stream into a treatment zone (2) having one or more membranes (M), passing the stream along the membranes (M) to recover permeate (4) and concentrate (3), while periodically reversing the flow direction at periods of time to prevent exposing the membranes (M) to supersaturation condition, thus preventing precipitation of the salts and minerals.

公开(公告)号：EP2126099A2

公开(公告)日：2009-12-02

申请号：EP08702660.5

申请日：2008-01-17

申请人： Yeda Research And Development Company Limited ,  Ben Gurion University Of The Negev Research And Development Authority

发明人： FLUHR, Robert ,  SAGI, Moshe

IPC分类号： C12N15/82 ,  C12N9/02 ,  C12N15/53 ,  A01H5/00

CPC分类号： C12N15/8271 ,  C12N9/0051

摘要： SO-modified transgenic plants overexpressing or lacking SO activity, having modified tolerance or susceptibility to toxicity of sulfite-producing substances, methods for their production and the use thereof for bioremediation of pollutants, as sentinel plants, for enhancing post-harvest quality of plants, plant tissues and plant products and for therapeutic applications.

公开(公告)号：EP1866649A1

公开(公告)日：2007-12-19

申请号：EP06711254.0

申请日：2006-02-28

申请人： Ben Gurion University of the Negev Research and Development Authority Ltd.

发明人： MAGRISSO, Moni ,  MARKS, Robert, S.

IPC分类号： G01N33/58 ,  G01N33/50 ,  G01N33/566 ,  C12Q1/28

CPC分类号： G01N33/5055 ,  C12Q1/28 ,  G01N21/76 ,  G01N33/582

摘要： A method of assessing the in vivo state of phagocytes in a patient, possibly indicating diagnostically important states such as inflammation or infection, which method utilizes chemiluminescent (CL) light emitted during the reaction in vitro between a CL substrate and the reactive oxygen species (ROS) formed in a fluid sample obtained from the patient. The measurement is performed in two or more portions of the sample, with stimulated phagocytes affected by one or more priming agents which shift the functional state of the phagocytes, providing a plurality of measurements, which are analyzed so as to distinguish intracellular and extracellular contributions to the CL kinetics. The results are compared with a range of control measurements performed with patients suffering from various diagnostic conditions.

公开(公告)号：EP1866266A2

公开(公告)日：2007-12-19

申请号：EP06744452.1

申请日：2006-03-20

申请人： Ben Gurion University of the Negev Research and Development Authority Ltd.

发明人： HERSKOWITZ, Mordechay ,  LANDAU, Miron ,  REIZNER, Iehudit ,  KALIYA, Mark

IPC分类号： C07C1/00 ,  C07C4/00 ,  C10G1/00 ,  C07C5/00 ,  C10L1/00 ,  C10L1/18 ,  C10L5/00

CPC分类号： C10G3/50 ,  C10G3/47 ,  C10G3/49 ,  C10G3/54 ,  C10G45/64 ,  C10G49/007 ,  C10G2300/1014 ,  C10G2300/1018 ,  C10G2300/20 ,  C10G2300/202 ,  C10G2300/307 ,  C10G2300/4006 ,  C10G2300/4012 ,  C10G2300/4018 ,  C10G2300/405 ,  C10G2300/4081 ,  C10G2300/42 ,  C10G2400/02 ,  C10G2400/04 ,  C10L1/026 ,  C10L1/04 ,  C10L1/08 ,  Y02P30/20

摘要： A process for producing a fuel composition from vegetable and/or animal oil comprises hydrodeoxygenating and hydroisomerizing the oil in a single step. The fuel composition has acceptable lubricity and comprises a mixture of C14 to C18 paraffins having a ratio of iso to normal paraffins of 2 to 8 and less than 5 ppm sulfur.