公开(公告)号：EP2359847A1

公开(公告)日：2011-08-24

申请号：EP10184820.8

申请日：2001-06-27

申请人： SCIOS INC.

发明人： Cordell, Barbara ,  Schimmoller, Frauke ,  Liu, Yu-Wang ,  Quon, Diana, Hom

IPC分类号： A61K38/48 ,  G01N33/50 ,  A61P25/28

CPC分类号： C12Q1/37 ,  C07K14/4711 ,  C12N9/6421 ,  G01N2500/04

摘要： The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

摘要翻译： 本发明基于以下发现：BACE2是分泌酶BACE的同系物，能够刺激非淀粉样蛋白生成途径中APP的加工，从而抑制A 2的水平。 因此，本发明提供了鉴定和使用BACE2独特活性调节剂以抑制A 2生产的方法和手段。 使用本文提供的方法和手段鉴定的化合物可以用作治疗阿尔茨海默病和其他神经疾病的潜在候选物。

公开(公告)号：EP2305815A1

公开(公告)日：2011-04-06

申请号：EP10013050.9

申请日：1999-07-08

申请人： Scios, Inc.

发明人： Pollitt, N. Stephen ,  Buckley, Douglas I. ,  Stathis, Peter A. ,  Hartman, Taymar E. ,  Zhong, Ziyang

IPC分类号： C12N15/12 ,  C12N15/62 ,  C07K1/18 ,  C07K1/12

CPC分类号： C07K1/36 ,  C07K1/122 ,  C07K14/58 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/75 ,  C12N9/1033 ,  C12N15/62 ,  C12P21/06 ,  C12Y203/01028

摘要： A method is described for producing a peptide having a pI above 8 or below 5 wherein the peptide is expressed as a fusion protein in which it is linked to a fusion partner through an acid cleavage site. The peptide is released from the fusion partner by acid cleavage in the absence of chaotrope. The fusion partner and its acid cleavage products, if any, have a net charge sufficiently different from that of the desired peptide to allow isolation of the peptide by ion-exchange chromatography.

摘要翻译： 描述了一种方法用于制造具有上述8或低于5的pI worin所述肽过表达其被通过酸裂解位点连接至融合伴侣的融合蛋白的肽。 将肽从融合伴侣通过酸裂解在不存在离液序列高的释放。 融合伴侣和其酸裂解产物，如果有的话，有一个净电荷充分differentFrom所做的所需肽的，以允许通过离子交换层析肽的隔离。

公开(公告)号：EP1607744A3

公开(公告)日：2009-09-30

申请号：EP05016779.0

申请日：1999-12-15

申请人： SCIOS INC.

发明人： Schreiner, George F. ,  Joly, Alison ,  White, R. Tyler

IPC分类号： G01N33/68 ,  C12Q1/68 ,  C07K14/475 ,  A61K45/06 ,  A61K38/21 ,  A61K31/5513 ,  A61P13/12 ,  A61P43/00

CPC分类号： A61K31/5513 ,  A61K38/191 ,  A61K45/06 ,  G01N33/948 ,  A61K2300/00

摘要： The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment of diagnosis of the target disease or condition.

公开(公告)号：EP1549316A4

公开(公告)日：2008-04-09

申请号：EP03754501

申请日：2003-09-10

申请人： SCIOS INC

发明人： AXON JONATHAN ,  CHAKRAVARTY SARVAJIT ,  DUGAR SUNDEEP ,  MCENROE GLEN ,  MURPHY ALISON

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P35/00 ,  C07D239/32 ,  C07D251/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

CPC分类号： C07D409/14 ,  C07D239/42 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

公开(公告)号：EP1511738A4

公开(公告)日：2007-05-09

申请号：EP03726892

申请日：2003-05-16

申请人： SCIOS INC

发明人： CHAKRAVARTY SARVAJIT ,  DUGAR SUNDEEP ,  HIGGINS LINDA S ,  KAPOUN ANN M ,  LIU DAVID Y ,  SCHREINER GEORGE F ,  PROTTER ANDREW A ,  TRAN THOMAS-TOAN

IPC分类号： A61K31/435 ,  A61K31/495 ,  A61K31/53 ,  C07D239/42 ,  C07D239/94 ,  C07D471/04

CPC分类号： A61K31/435 ,  A61K31/495 ,  A61K31/53

公开(公告)号：EP1720562A1

公开(公告)日：2006-11-15

申请号：EP05705830.7

申请日：2005-01-18

申请人： Scios, Inc.

发明人： KAPOUN, Ann, M. ,  SCHREINER, George, F. ,  LIANG, Faquan ,  LI, Zhihe

IPC分类号： A61K38/00

CPC分类号： A61K38/2242

摘要： The invention concerns methods for treating cardiac remodeling in a subject who has undergone myocardial injury, said method comprising the administration of natriuretic peptide to said subject. Preferably the natriuretic peptide is brain natriuretic peptide. The invention also concerns methods for treating structural heart disorders arising from myocardial injury, said method comprising the administration of a natriuretic peptide to a patient in need thereof.

公开(公告)号：EP1708712A1

公开(公告)日：2006-10-11

申请号：EP04815564.2

申请日：2004-12-22

申请人： Scios, Inc.

发明人： WELLER, Michael

IPC分类号： A61K31/517 ,  A61K31/53 ,  A61K31/505 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K31/505 ,  A61K31/517 ,  A61K31/53 ,  A61K31/55

摘要： The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-β the TGF-β signaling pathway, including molecules preferably binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-β-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-β.

公开(公告)号：EP1551807A4

公开(公告)日：2006-09-13

申请号：EP03764582

申请日：2003-07-11

申请人： SCIOS INC

发明人： MAVUNKEL BABU ,  PERUMATTAM JOHN JOSEPH ,  TESTER RICHLAND WAYNE ,  DUGAR SUNDEEP

IPC分类号： C07C239/20 ,  C07D215/24 ,  C07D209/42

CPC分类号： C07C239/20

摘要： Improved reagents and methods of amination are provided. The reagents are phenyl hydroxylamines containing one nitro and at least one CF3 substituent on the phenyl moiety.

公开(公告)号：EP1305406B1

公开(公告)日：2006-09-13

申请号：EP01935260.8

申请日：2001-05-09

申请人： SCIOS INC.

发明人： CORDELL, Barbara ,  HIGAKI, Jeffrey, N. ,  MUTZ, Mitchell

IPC分类号： C12N9/64 ,  C07K14/47 ,  G01N33/68 ,  A61K38/17 ,  A61K38/43

CPC分类号： C12N9/6421 ,  A61K38/00 ,  C07K14/4711

摘要： The present invention provides cell-free η-secretase activity. The method of the invention utilizes a membrane source of APP/η-secretase mixture in the assay to determine factors that may enhance or decrease enzymatic activity affecting β-amyloid peptide production. The cell membranes used in the assay may be from cells expressing an endogenous APP or, preferably, cells expressing a recombinant APP. The APP may be full-length or a fragment capable of being proteolytically cleaved by η-secretase. In addition, the APP expressed in the cells may have one or more mutation, such as a point mutation, small deletion, etc.

公开(公告)号：EP0914344B8

公开(公告)日：2005-08-10

申请号：EP97907946.4

申请日：1997-03-04

申请人： SCIOS INC.

发明人： MISCHAK, Ronald, P. ,  LIM, Garret, A. ,  SCARDINA, Jan, Marian

IPC分类号： C07K16/26 ,  C07K7/00 ,  C07K14/58 ,  C12N5/12 ,  G01N33/53 ,  G01N33/577

CPC分类号： C07K14/58 ,  C07K16/26 ,  C07K2317/34 ,  Y10S530/839 ,  Y10S530/841

摘要： The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of hBNP. These antibodies, and peptide fragments containing these sequences, can be employed in the assays of the invention, which may be carried out in a sandwich format or a competition format.