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    IDENTIFICATION OF NOVEL DISEASE STATES USING VISCOELASTIC ANALYSIS IN THE PRESENCE OF A THROMBOLYTIC AGENT
    23.
    发明公开
    IDENTIFICATION OF NOVEL DISEASE STATES USING VISCOELASTIC ANALYSIS IN THE PRESENCE OF A THROMBOLYTIC AGENT 审中-公开
    在存在溶栓剂的情况下使用粘弹性分析鉴定新型疾病状态

    公开(公告)号：EP3215634A1

    公开(公告)日：2017-09-13

    申请号：EP15856414.6

    申请日：2015-11-05

    申请人： The Regents of the University of Colorado

    发明人： CHAPMAN, Michael P. ,  MOORE, Hunter B. ,  BARREDA, Eduardo Gonzalez ,  MOORE, Ernest E.

    IPC分类号： C12Q1/56 ,  G01N33/86 ,  A61K38/36 ,  A61P7/02

    CPC分类号： G01N33/86 ,  A61K38/36 ,  C12Q1/56 ,  G01N2800/224 ,  G01N2800/226

    摘要： In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent.

    摘要翻译： 在一些实施方案中，本发明提供了用于检测患者中的异常纤维蛋白溶解状况的方法。 该方法包括使来自患者的血液样品在存在已知量的血栓溶解剂的情况下进行粘弹性分析，以获得患者的凝血特征值; 并且比较患者的凝血特性值和健康个体的凝血特性值，通过对来自健康个体的血液样品进行粘弹性分析，在已知量的 其中与健康个体的凝血特征值相比，患者的凝血特征值的差异将该专利识别为具有异常纤维蛋白溶解。在一些实施方案中，本发明还提供了适于检测异常纤维蛋白溶解病症 在使用粘弹性分析的血液样品中包含具有包含血栓溶解剂的包衣的内部。

    METHOD OF DETECTING PLATELET ACTIVATING ANTIBODIES THAT CAUSE HEPARIN-INDUCED THROMBOCYTOPENIA/THROMBOSIS
    24.
    发明公开
    METHOD OF DETECTING PLATELET ACTIVATING ANTIBODIES THAT CAUSE HEPARIN-INDUCED THROMBOCYTOPENIA/THROMBOSIS 审中-公开
    检测方法的血小板活化抗体的肝素罪犯诱导的血小板减少/血栓形成

    公开(公告)号：EP3063544A4

    公开(公告)日：2017-03-29

    申请号：EP14857347

    申请日：2014-10-28

    申请人： BLOODCENTER RES FOUND

    发明人： ASTER RICHARD H ,  BOUGIE DANIEL W ,  JONES CURTIS GERALD ,  PADMANABHAN ANAND

    IPC分类号： G01N33/86 ,  C12Q1/56

    CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N33/56966 ,  G01N33/6854 ,  G01N2333/70564 ,  G01N2800/222 ,  G01N2800/224 ,  G01N2800/226

    摘要： The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (HIT); b) incubating an effective amount of platelet factor 4 (PF4) with a sample of platelets to yield a sample of PF4-treated platelets; c) contacting the patient blood sample with the PF4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having HIT.

    摘要翻译： 本发明提供了检测患者中的血小板活化的方法，该方法包括的从怀疑具有肝素诱导性血小板减少症（HIT）的患者的血液样品的步骤）; b）在有效量的血小板因子4（PF4）的与血小板的样品孵化以产生PF4处理的血小板的样本; c）使与PF4处理的血小板中的患者的血液样品; 和d）测量血小板活化的程度，worin在血小板活化，以增加与使用正常的血液样品获得的结果相比是表示具有HIT患者。

    METHOD FOR MEASURING CLOTTING TIME, MEASUREMENT DEVICE FOR CLOTTING TIME, CLOTTING TIME MEASURING REAGENT, AND REAGENT KIT
    25.
    发明公开
    METHOD FOR MEASURING CLOTTING TIME, MEASUREMENT DEVICE FOR CLOTTING TIME, CLOTTING TIME MEASURING REAGENT, AND REAGENT KIT 审中-公开
    法测量凝固时间用于测量凝血时间，与GERINNUNGSZEITMESSREAGENZ试剂盒

    公开(公告)号：EP3124978A1

    公开(公告)日：2017-02-01

    申请号：EP16181818.2

    申请日：2016-07-29

    申请人： SYSMEX CORPORATION ,  School Juridical Person Higashi-Nippon-Gakuen

    发明人： KUMANO, Osamu ,  YAMAGUCHI, Haruki ,  SUZUKI, Takeshi , 

    IPC分类号： G01N33/86

    CPC分类号： G01N33/86 ,  G01N21/82 ,  G01N33/4905 ,  G01N2405/04 ,  G01N2800/224

    摘要： Disclosed is a method for measuring a clotting time, including:
    a mixing step of mixing a blood sample, an activator, a phospholipid, and a manganese ion-forming compound to obtain a specimen; and
    a measurement step of mixing the specimen obtained in the mixing step with a calcium salt to prepare a measurement specimen and measuring the clotting time of the measurement specimen,
    wherein the blood sample is mixed with the manganese ion-forming compound separately from the activator and the phospholipid in the mixing step.

    摘要翻译： 公开的是用于测量凝血时间的方法，包括：混合血液样品，与活化剂，磷脂，和锰离子形成化合物，以获得试样的混合工序; 和混合在与钙盐的混合工序中得到的样品制备的测定试样，测定测定试样的凝血时间，worin血液样品的测定步骤是在所述的锰离子形成化合物分别从活化剂混合，并 磷脂在混合步骤。

    BLOOD FACTOR MONITORING ASSAY AND USES THEREOF
    29.
    发明公开
    BLOOD FACTOR MONITORING ASSAY AND USES THEREOF 审中-公开
    验血因子监测及其用途

    公开(公告)号：EP2877202A2

    公开(公告)日：2015-06-03

    申请号：EP13823087.5

    申请日：2013-07-25

    申请人： Biogen Idec MA Inc.

    发明人： SOMMER, Jurg

    IPC分类号： A61K38/37 ,  A61K38/36 ,  C07K14/755

    CPC分类号： G01N33/86 ,  G01N33/92 ,  G01N2333/755 ,  G01N2333/9645 ,  G01N2800/224

    摘要： The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.