公开(公告)号：EP0235452A3

公开(公告)日：1988-10-26

申请号：EP86309402

申请日：1986-12-03

Applicant: LILLY INDUSTRIES LIMITED

Inventor： BAKER, STEPHEN RICHARD ,  TODD, ALEC

IPC: A61K31/10 ,  A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/41 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/02 ,  C07C317/18 ,  C07C317/24 ,  C07C317/28 ,  C07C317/44 ,  C07C321/20 ,  C07C323/22 ,  C07C323/29 ,  C07C323/56 ,  C07C323/65 ,  C07D257/04

CPC classification number: C07D257/04 ,  Y02P20/55

公开(公告)号：EP3956334A1

公开(公告)日：2022-02-23

申请号：EP20718675.0

申请日：2020-04-17

Applicant: Merck Patent GmbH

Inventor： GERSTENECKER, Stefan

IPC: C07F7/18 ,  C07D309/10 ,  C07C69/54 ,  C07C69/653 ,  C07C255/47 ,  C07C255/54 ,  C07C309/65 ,  C07C309/67 ,  C07C317/18 ,  C07C323/12 ,  C07C323/18 ,  C07C323/65 ,  C07C327/28 ,  B29D11/00 ,  C08F220/24 ,  C08F224/00

公开(公告)号：EP3042924A4

公开(公告)日：2017-05-10

申请号：EP14842596

申请日：2014-09-02

Applicant: DAINIPPON INK & CHEMICALS ,  NAT UNIV CORP IWATE UNIV

Inventor： WATANABE HAJIME ,  FURUSAWA TAKASHI ,  OGAWA SATOSHI ,  TAKATA TOSHIKAZU

IPC: C07C317/22 ,  C07C323/65

CPC classification number: C08G75/14 ,  C07C317/22 ,  C07C321/30 ,  C07C323/65 ,  C08G75/0272 ,  C08G75/0286 ,  C08G75/12

Abstract: The present invention relates to a method for manufacturing a polyarylene sulfide resin comprising: reacting a sulfoxide represented by the following formula (1) with a particular aromatic compound to obtain a poly(arylenesulfonium salt) having a particular constitutional unit; and dealkylating or dearylating the poly(arylenesulfonium salt) to obtain a polyarylene sulfide resin having a particular constitutional unit, wherein R 1 represents an alkyl group having 1 to 10 carbon atoms, etc.; Ar 1 and Ar 2 each independently represent an arylene group optionally having a substituent; and Z represents a direct bond, etc.

Abstract translation: 聚芳硫醚树脂的制造方法技术领域本发明涉及一种聚芳硫醚树脂的制造方法，其特征在于，使下述式（1）所示的亚砜与特定的芳香族化合物反应，得到具有特定结构单元的聚（亚芳基锍盐） 并将聚（亚芳基锍盐）脱烷基化或脱芳基化，得到具有特定结构单元的聚亚芳基硫醚树脂，其中R 1表示具有1至10个碳原子的烷基等; Ar 1及Ar 2分别独立地表示可以具有取代基的亚芳基， Z代表直接键合等。

公开(公告)号：EP3138832A1

公开(公告)日：2017-03-08

申请号：EP16190952.8

申请日：2005-03-15

Applicant: Temple University - Of The Commonwealth System of Higher Education ,  Onconova Therapeutics, Inc.

Inventor： REDDY, Premkumar E. ,  REDDY, Ramana M. V. ,  BELL, Stanley C.

IPC: C07C235/38 ,  C07C271/44 ,  C07D213/02 ,  C07D295/088 ,  C07D295/15 ,  C07D295/155 ,  C07C311/27 ,  C07C317/18 ,  C07C317/28 ,  C07C323/41 ,  C07C323/49 ,  C07C323/65 ,  C07F7/18 ,  A61K31/223 ,  A61P35/00

CPC classification number: C07C235/38 ,  C07B2200/07 ,  C07C271/44 ,  C07C311/27 ,  C07C317/18 ,  C07C317/28 ,  C07C323/41 ,  C07C323/49 ,  C07C323/65 ,  C07D213/02 ,  C07D295/088 ,  C07D295/15 ,  C07D295/155 ,  C07F7/1852 ,  C07F7/1856

Abstract: Abstract of the Disclosure
Substituted phenol derivatives of Formula I:

are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

Abstract translation: 公开说明书的摘要式I的取代苯酚衍生物可用作抗增殖剂，包括例如抗癌剂，以及作为放射防护和化学保护剂。

公开(公告)号：EP2507209B1

公开(公告)日：2015-07-08

申请号：EP10787664.1

申请日：2010-12-05

Applicant: Merial, Inc. ,  BASF SE

Inventor： MENG, Charles, Q. ,  POHLMAN, Matthias ,  BASTIAANS, Henricus, Maria, Martinus ,  PAULINI, Ralph ,  SOERGEL, Sebastian

IPC: C07C323/60 ,  C07C323/65 ,  C07C327/42 ,  A01N37/18 ,  A01N37/34 ,  A01N43/40 ,  A01N43/56 ,  C07D213/64 ,  C07D231/12

CPC classification number: C07C323/65 ,  A01N37/36 ,  A01N41/10 ,  A01N43/40 ,  A01N43/56 ,  A01N43/653 ,  A01N43/82 ,  A01N47/02 ,  C07C323/60 ,  C07C327/42 ,  C07D213/64 ,  C07D231/12

公开(公告)号：EP2548860A1

公开(公告)日：2013-01-23

申请号：EP11756144.9

申请日：2011-03-09

Applicant: Sumitomo Seika Chemicals Co. Ltd.

Inventor： KUAD, Paul ,  KANDA, Hisaaki ,  FUJIWARA, Takeshi ,  SHIRAISHI, Hiroyuki

IPC: C07C323/65 ,  C07C319/20

CPC classification number: C07C323/65

Abstract: The present invention provides a diaryl sulfone compound represented by Formula (1):

wherein R 1 to R 4 and R 1' to R 4' are the same or different, and each represents hydrogen, C 1-4 alkyl, or halogen, and R 5 represents C 2-6 alkenyl, C 1-4 alkyl, or aromatic heterocyclic group;
a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4'-dihaloarylsulfone compound with thiol salt compound having an alkylene group; and
a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4'-dihaloarylsulfone compound with a thiol salt compound having a hydroxyl group, and subjecting the resulting compound to reaction with a halogenating agent, followed by a dehydrohalogenation reaction.

Abstract translation: 本发明提供由式（1）表示的二芳基砜化合物：其中R 1至R 4和R 1'至R 4'相同或不同，并且各自表示氢，C 1-4烷基或卤素，并且R 5表示C 2-6 烯基，C 1-4烷基或芳族杂环基; 通过使4,4'-二卤代芳基砜化合物与具有亚烷基的硫醇盐化合物反应来制造式（1）所示的二芳基砜化合物的方法; 以及通过使4,4'-二卤代芳基砜化合物与具有羟基的硫醇盐化合物反应，使所得化合物与卤化剂反应，接着制备由式（1）表示的二芳基砜化合物的方法 脱卤化氢反应。

公开(公告)号：EP2297095B9

公开(公告)日：2013-01-09

申请号：EP09745768.3

申请日：2009-05-13

Applicant: Pharmaleads

Inventor： FOURNIE-ZALUSKI, Marie-Claude ,  PORAS, Hervé ,  ROQUES, Bernard

IPC: C07C323/60 ,  C07C323/65

CPC classification number: C07C323/65 ,  C07C323/60

公开(公告)号：EP2297095B1

公开(公告)日：2012-04-25

申请号：EP09745768.3

申请日：2009-05-13

Applicant: Pharmaleads

Inventor： FOURNIE-ZALUSKI, Marie-Claude ,  PORAS, Hervé ,  ROQUES, Bernard

IPC: C07C323/60 ,  C07C323/65

CPC classification number: C07C323/65 ,  C07C323/60

Abstract: The invention relates to novel compounds of the formula (I) R
1 NH-CH(R
2 )-CH
2 -S- S-CH
2 -C(R
3 )(R
4 )-CONH-C(R
5 )(R
6 )-COOR
7 , in which R
1 is a (acyloxy)alkyl carbamate -C(O)-O-C(R
8 )(R
9 )-OC(O)-R
10 group; R
2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle; R
4 is a hydrogen atom and R
3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R
3 and R
4 form together a saturated cycle; R
5 and R
6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R
5 and R
6 form together a saturated cycle; R
7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR
12 (R
13 )C(O)OR
14 or OCR
12 (R
13 )OC(O)R
14 or OCR
12 (R
13 )OC(O)OR
14 . The invention also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The invention further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the novel compounds of the formula (I).

公开(公告)号：EP2327689B1

公开(公告)日：2012-02-29

申请号：EP10015054.9

申请日：2010-11-26

Applicant: Adeka Corporation

Inventor： Murata, Kiyoshi ,  Oishi, Takeo ,  Kimijima, Koichi

IPC: C07C323/47 ,  C07C323/65 ,  C07C391/02 ,  C07F9/50 ,  C07C251/66 ,  C07C251/68 ,  C08F2/50

CPC classification number: C08F2/50 ,  B33Y70/00 ,  C07C251/66 ,  C07C323/47 ,  C07C323/65 ,  C07C391/02 ,  C07C2601/14 ,  C07F9/5022 ,  G03F7/0042 ,  G03F7/0045 ,  G03F7/031 ,  G03F7/033 ,  G03F7/105 ,  Y10S430/114

公开(公告)号：EP1963259B1

公开(公告)日：2012-02-15

申请号：EP06820474.2

申请日：2006-12-12

Applicant: AstraZeneca AB

Inventor： BONNERT, Roger, Victor ,  LUKER, Timothy, Jon ,  MOHAMMED, Rukhsana, Tasneem ,  THOM, Stephen ,  COOK, Andrew

IPC: C07D257/04 ,  C07C317/22 ,  C07C323/65 ,  C07C311/51 ,  A61K31/18 ,  A61P11/00 ,  A61K31/275

CPC classification number: C07C317/22 ,  C07C317/44 ,  C07C323/65 ,  C07D205/04 ,  C07D231/20 ,  C07D233/64 ,  C07D257/04 ,  C07D271/07 ,  C07D401/12 ,  C07D403/04

Abstract: The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory- disorders, pharmaceutical compositions containing them, and processes for their preparation.