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67 条记录 (耗时 0.018 秒)

    DOUBLE-ACYLATED GLP-1 DERIVATIVES
    22.
    发明公开
    DOUBLE-ACYLATED GLP-1 DERIVATIVES 有权
    双酰化GLP-1衍生物

    公开(公告)号：EP2696687A1

    公开(公告)日：2014-02-19

    申请号：EP12713164.7

    申请日：2012-04-12

    申请人： Novo Nordisk A/S

    发明人： WIECZOREK, Birgit ,  SPETZLER, Jane ,  KRUSE, Thomas ,  LINDEROTH, Lars ,  KOFOED, Jacob

    IPC分类号： A01N43/90 ,  A01N61/00 ,  A01P3/00 ,  A61K38/26 ,  C07K14/065

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26 ,  A61K47/542 ,  A61K47/60

    摘要： The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1 (7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1 (7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1 (7-37); wherein the first K residue is designated K 27 , and the second K residue is designated K T ; which derivative comprises two albumin binding moieties attached to K 27 and K T , respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC-(CH 2 ) x -CO- and HOOC-C 6 H 4 -O-(CH 2 ) y -CO-; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula -NH-(CH 2 ) 2 -(O-(CH 2 ) 2 ) k -O-(CH 2 ) n -CO-, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel GLP-1 analogues. The derivatives are suitable for oral administration.

    ANTI-APOPTOTIC FUSION PROTEINS
    23.
    发明公开
    ANTI-APOPTOTIC FUSION PROTEINS 有权
    抗凋亡融合蛋白

    公开(公告)号：EP2350121A1

    公开(公告)日：2011-08-03

    申请号：EP09748796.1

    申请日：2009-11-10

    申请人： Fändrich, Fred

    发明人： KUNZENDORF, Ulrich ,  KRAUTWALD, Stefan

    IPC分类号： C07K14/065 ,  A61K38/55 ,  C07K14/81

    CPC分类号： C07K14/8121 ,  A61K38/00 ,  C07K14/005 ,  C07K14/811 ,  C07K2319/10 ,  C12N2710/24122

    摘要： The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising the amino acid of the sequence of SEQ ID NO:1 or an anti-apoptotically active variant or fragment thereof. The invention also relates to a pharmaceutical composition comprising such a fusion protein, in particular for blocking apoptosis in a patient in need thereof. The invention also provides a polynucleotide encoding such a fusion protein, an expression vector comprising the polynucleotide and a host cell comprising the expression vector. In a further aspect, the invention relates to the use of any of theses materials for the preparation of a medicament for blocking apoptosis in a patient in need thereof.

    PLANTS AND FEED BAITS FOR CONTROLLING DAMAGE FROM FEEDING INSECTS
    28.
    发明公开
    PLANTS AND FEED BAITS FOR CONTROLLING DAMAGE FROM FEEDING INSECTS 有权
    植物及其产品损害的控制由于吃虫饵衬

    公开(公告)号：EP1158850A4

    公开(公告)日：2004-03-31

    申请号：EP00908824

    申请日：2000-03-10

    申请人： COMMW SCIENT IND RES ORG

    发明人： DALL DAVID JAMES

    IPC分类号： A01N25/00 ,  A01N63/02 ,  C07K14/01 ,  C07K14/065 ,  C12N15/82 ,  A01H5/00

    CPC分类号： C07K14/005 ,  A01N25/006 ,  A01N63/02 ,  C12N15/8286 ,  C12N2710/24022 ,  Y02A40/162

    摘要： Plants are disclosed which are capable of expressing, in a tissue or tissues susceptible to damage by feeding insects, an exogenous protein(s) such as fusolin or a fusolin-like protein, to reduce damage to the plant by inhibiting feeding, growth and/or development of insects. Feed baits comprising spindle bodies, spindle-like bodies or constituent protein(s) thereof which inhibit feeding, growth and/or development of insects are also disclosed.

    摘要翻译： 植物盘游离缺失哪些是能够表达，在组织或组织易于损坏通过将昆虫外源蛋白质（S）：如fusolin或fusolin样蛋白，以减少对植物的损害通过抑制摄食，生长和/ 或昆虫的发展。 进料包括毒饵主轴机构，纺锤状体或组分蛋白（多个）部分抑制喂养，昆虫的生长和/或发育是如此游离缺失盘。