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105 条记录 (耗时 0.028 秒)

    TRANS-TUMORAL PEPTIDE SPECIFIC TO NEUROPILIN AND FUSION PROTEIN HAVING SAME PEPTIDE FUSED THEREIN
    31.
    发明公开
    TRANS-TUMORAL PEPTIDE SPECIFIC TO NEUROPILIN AND FUSION PROTEIN HAVING SAME PEPTIDE FUSED THEREIN 审中-公开
    TRANSTUMORALES肽特异性的神经毡及融合蛋白凝结肽

    公开(公告)号：EP3000825A1

    公开(公告)日：2016-03-30

    申请号：EP14800779.2

    申请日：2014-05-22

    申请人： Ajou University Industry-Academic Cooperation Foundation

    发明人： KIM, Yong Sung ,  SHIN, Tae Hwan ,  KIM, Yae Jin ,  SUNG, Eun Sil

    IPC分类号： C07K14/435 ,  C07K19/00 ,  A61K38/17 ,  A61P35/00

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30

    摘要： The present invention relates to a tumor tissue-penetrating peptide specifically binding to neuropilin, or a fusion protein, a small molecule drug, a nanoparticle, or a liposome having the peptide fused therein. In addition, the present invention relates to a method for preparing the same and a pharmaceutical composition comprising the same for treating, diagnosing, or preventing cancer or angiogenesis-related diseases. The fusion antibody in which a tumor tissue-penetrating peptide according to the present invention is fused to the C-terminus of an anticancer antibody heavy-chain constant region (Fc) achieves the property of specifically binding to neuropilin, and thereby, specifically accumulates in tumor tissue, widens intercellular gaps between tumor vascular endothelial cells, promotes extravasation, increases infiltration within tumor tissue, and thus, shows a remarkably increased in vivo tumor-suppressing activity. Furthermore, the fusion protein having a tumor tissue-penetrating peptide according to the present invention fused therein inhibits the angiogenic function among the functions of neuropilin coreceptors resulting from targeting of neuropilin, and is therefore expected to have an alleviating effect on angiogenesis-related diseases.

    CH3 DOMAIN VARIANT PAIR INDUCING FORMATION OF HETERODIMER OF HEAVY CHAIN CONSTANT REGION OF ANTIBODY AT HIGH EFFICIENCY, METHOD FOR PREPARING SAME, AND USE THEREOF
    32.
    发明公开
    CH3 DOMAIN VARIANT PAIR INDUCING FORMATION OF HETERODIMER OF HEAVY CHAIN CONSTANT REGION OF ANTIBODY AT HIGH EFFICIENCY, METHOD FOR PREPARING SAME, AND USE THEREOF 审中-公开
    CH3域选项FEW对诱导恒异源二聚体重链的抗体区AT高精度法的形成用于其和使用及其生产

    公开(公告)号：EP2927321A1

    公开(公告)日：2015-10-07

    申请号：EP13859121.9

    申请日：2013-11-27

    申请人： Ajou University Industry-Academic Cooperation Foundation

    发明人： KIM, Yong Sung ,  CHOI, Hye Ji ,  SUNG, Eun Sil

    IPC分类号： C12N15/13 ,  C07K16/18 ,  C07K16/46 ,  A61K39/395

    CPC分类号： C07K16/46 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2878 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2319/30

    摘要： The present invention relates to a CH3 domain variant pair of an antibody, to a method for preparing same, and to a use thereof, wherein a mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer according to the present invention, forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer of the present invention, and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.

    摘要翻译： 本发明涉及到CH3结构域的变体对的抗体，涉及一种制备方法，以及它们的用途，worin突变在CH3结构域诱导的，从而改善形成的异源二聚体重链恒定区的屈服 的抗体。 CH3结构域的异源二聚体gemäß到本发明中，形成异源二聚体重链恒定区具有90％至95％以上的高效率，并因此具有优异的热稳定性。 甲异二聚体重链恒定区包含CH3结构域的异源二聚体可以构建双特异性单克隆抗体，其同时识别两种种抗原。 本发明的CH3结构域的异源二聚体，和抗体恒定区，其包含相同的双特异性抗体或融合蛋白可有效地应用于具有靶抗原或靶蛋白相关的疾病的治疗或预防。

    RANDOM ACCESS METHOD AND APPARATUS IN WIRELESS COMMUNICATION SYSTEM
    35.
    发明公开
    RANDOM ACCESS METHOD AND APPARATUS IN WIRELESS COMMUNICATION SYSTEM 审中-公开
    EIRE DRAHTLOSEN KOMMUNIKATIONSSYSTEM中的DIREKTZUGANGSVERFAHREN UND -VORRICHTUNG

    公开(公告)号：EP2564653A2

    公开(公告)日：2013-03-06

    申请号：EP11775213.9

    申请日：2011-04-22

    申请人： Ajou University Industry-Academic Cooperation Foundation

    发明人： OH, Seong-Keun ,  LEE, Min

    IPC分类号： H04W74/08 ,  H04W88/02 ,  H04B7/26

    CPC分类号： H04W74/0875

    摘要： Disclosed is a method of performing random access by a User Equipment (UE) in a wireless communication system. The method includes generating at least two random access signals with their own priorities, and transmitting the at least two random access signals with their own priorities. The random access method may include transmitting at least two random access signals to at least two target communication nodes. Further, the random access method may include transmitting at least one random access signal, and selecting at least one of at least two random access response signals received in response to the at least one random access signal and performing random access control by using the selected random access response signals.

    摘要翻译： 公开了一种在无线通信系统中执行用户设备（UE）的随机接入的方法。 该方法包括产生具有它们自己的优先级的至少两个随机接入信号，并且以其自己的优先级发送至少两个随机接入信号。 随机接入方法可以包括向至少两个目标通信节点发送至少两个随机接入信号。 此外，随机接入方法可以包括：发送至少一个随机接入信号，以及选择响应于所述至少一个随机接入信号而接收到的至少两个随机接入响应信号中的至少一个，并通过使用所选择的随机接入控制来执行随机接入控制 访问响应信号。

    Apparatus and method for actively tracking multiple moving objects using a monitoring camera
    37.
    发明公开
    Apparatus and method for actively tracking multiple moving objects using a monitoring camera 审中-公开
    装置和方法用于使用监视摄像机有源跟踪多个移动对象

    公开(公告)号：EP2402905A1

    公开(公告)日：2012-01-04

    申请号：EP11169032.7

    申请日：2011-06-08

    申请人： Ajou University Industry-Academic Cooperation Foundation

    发明人： Cho, Shung-Han ,  Hong, Sang-Jin ,  Kim, Yang-Weon ,  Cho, We-Duke ,  Hwang, Yong-Hyeon ,  Nam, Yun-Young

    IPC分类号： G06T3/40 ,  G06T7/20 ,  H04N7/18

    CPC分类号： G06T3/40 ,  G06T7/254 ,  G06T2207/20021 ,  H04N7/185

    摘要： An apparatus for actively tracking an object is provided. The apparatus includes a camera unit; a motor drive for changing a shooting direction of the camera unit; and a controller for acquiring a first comparative image and a second comparative image in sequence using the camera unit, dividing each of the first and second comparative images into a plurality of sectors, comparing a first sector in the first comparative image with a second sector in the second comparative image, which corresponds to the first sector, detecting a moving direction and a speed of an identical object existing in the first and second sectors, determining an estimated location of the object after receipt of the second comparative image based on the detected moving direction and speed, enlarging a sector corresponding to the estimated location of the object among the plurality of sectors, and capturing a target image.

    摘要翻译： 提供了一种用于对象的积极跟踪的装置。 该设备包括：照相机单元; 一个马达驱动，用于改变所述摄像机单元的拍摄方向; 以及使用该摄像机单元顺序获取第一比较图像和第二比较图像，将每个所述第一和第二比较图像的成扇区的复数，将第一比较图像与第二扇区中进行比较的第一扇区的控制器 第二比较图像，其对应于所述第一扇区，检测移动方向和存在于第一和第二分区中的相同物体的速度，后上的对象的估计的位置确定性采矿收据基于检测到的第二比较图像的移动 方向和速度，扩大的扇区的扇区的多元性中对应于目标的估计位置，并捕获目标的图像。

    APPARATUS AND METHOD FOR RELAYING MULTIPLE LINKS IN A COMMUNICATION SYSTEM
    38.
    发明公开
    APPARATUS AND METHOD FOR RELAYING MULTIPLE LINKS IN A COMMUNICATION SYSTEM 审中-公开
    装置和方法对多个连接在通信系统的传输

    公开(公告)号：EP2392191A2

    公开(公告)日：2011-12-07

    申请号：EP10736078.6

    申请日：2010-02-02

    申请人： Ajou University Industry-Academic Cooperation Foundation

    发明人： OH, Seong-Keun ,  LEE, Min

    IPC分类号： H04W88/04

    CPC分类号： H04W28/08 ,  H04B7/155 ,  H04B7/15592 ,  H04B7/2606 ,  H04W84/047

    摘要： An apparatus and method for transmitting and receiving control data and user data between multiple communication stations using multiple backhaul links in a communication system, in which a Multi-Link Relay Station (MLRS) generates multiple backhaul links for data transmission/reception between multiple communication stations, and provides a multi-homing service for mobile stations using the generated multiple backhaul links. The MLRS may also support a handover for mobile stations using the multiple backhaul links. The use of multiple backhaul links facilitates efficient transmission/reception of control data and/or user data between multiple base stations or multiple relay stations.