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    HANSENULA POLYMORPHA YAPSIN DEFICIENT MUTANT STRAIN AND PROCESS FOR THE PREPARATION OF RECOMBINANT PROTEINS USING THE SAME
    31.
    发明公开
    HANSENULA POLYMORPHA YAPSIN DEFICIENT MUTANT STRAIN AND PROCESS FOR THE PREPARATION OF RECOMBINANT PROTEINS USING THE SAME 有权
    YAPSIN-MANGELMUTANTENSTAMM VON HANSENULA POLYMORPHA SOWIE VERFAHREN ZUR HERSTELLUNG REKOMBINANTER PROTEINE DAMIT

    公开(公告)号：EP1534835A4

    公开(公告)日：2005-12-14

    申请号：EP03736354

    申请日：2003-06-28

    申请人： KOREA RES INST OF BIOSCIENCE ,  LEADBIO INC ,  BIOHOLDINGS CO LTD

    发明人： KANG HYUN-AH ,  RHEE SANG-KI ,  SOHN MIN-JEONG ,  KIM JEONG-YOON

    IPC分类号： C12N9/58 ,  C12N15/31 ,  C12N15/81 ,  C12P21/02 ,  C12P21/06

    CPC分类号： C12N9/58 ,  C07K2319/02 ,  C12N15/815 ,  C12P21/02 ,  C12P21/06

    摘要： The present invention relates to polynucleotide containing HpYPS1 gene coding Hansenula polymorpha yapsin1; polypeptide coded thereby; Hansenula polymorpha mutant wherein yapsin activity is reduced by the mutation of the HpYPS1 gene coding Hansenula polymorpha yapsin1; recombinant Hansenula polymorpha strain expressing a foreign protein prepared by introducing a gene coding a foreign protein to the Hansenula polymorpha mutant; and a method for preparing a foreign protein comprising the steps of culturing the recombinant Hansenula polymorpha strain under the condition that the foreign protein can be expressed, and isolating the foreign protein from the obtained culture broth.

    摘要翻译： 本发明涉及含有编码多形汉逊酵母Yapsin1的HpYPS1基因的多核苷酸; 由此编码的多肽; 多形汉逊酵母突变体，其中由于编码多形汉逊酵母Yapsin1的HpYPS1基因的突变降低了耶那囊蛋白活性; 表达外源蛋白质的重组多形汉逊酵母菌株，其通过将编码外源蛋白质的基因导入多形汉逊酵母突变体而制备; 以及制备外源蛋白质的方法，该方法包括在外源蛋白质可以表达的条件下培养重组多形汉逊酵母菌株并从所得培养液中分离外源蛋白质的步骤。

    HERICIUM ERINACEUM-DERIVED LECTIN SPECIFIC FOR SIALIC ACID LINKAGE
    34.
    发明公开
    HERICIUM ERINACEUM-DERIVED LECTIN SPECIFIC FOR SIALIC ACID LINKAGE 有权
    FÜRSIALINSÄUREBINDUNGSPEZIFISCHES LECTIN AUS HERICIUM ERINACEUM

    公开(公告)号：EP3072954A4

    公开(公告)日：2016-10-19

    申请号：EP14862325

    申请日：2014-11-14

    申请人： KOREA RES INST OF BIOSCIENCE

    发明人： KIM SEONGHUN

    IPC分类号： C12N1/14 ,  C07K14/37 ,  C07K14/42

    CPC分类号： C07K14/375 ,  C07K14/37 ,  G01N33/582 ,  G01N33/6848 ,  G01N2333/42

    摘要： The present invention concerns lectins isolated from the fruiting body of a novel Hericium erinaceum (deposit number: KCTC 12499BP) NEU-1 L strain which bind specifically to sialic acid. The invention further pertains to uses of such lectinsn abd to processes for their preparation thereby. The lectin of the present invention can be useful as an active ingredient of a composition or a kit for measuring or detecting glycoproteins, glycopeptides, glycolipids, sugar precursors or oligosaccharides containing sialic acid moieties, or further for measuring or detecting cell lines, bacteria and viruses containing sialoglycoconjugates.

    摘要翻译： 本发明涉及从与唾液酸特异性结合的新型赫氏酵母（保藏号：KCTC 12499BP）NEU-1L菌株的子实体分离的凝集素。 本发明进一步涉及这种凝集素abd的用途，因此其制备方法。 本发明的凝集素可用作用于测量或检测糖蛋白，糖肽，糖脂，糖前体或含有唾液酸部分的寡糖或进一步用于测量或检测细胞系，细菌和病毒的组合物或试剂盒的活性成分 含有sialoglycoconjugates。