利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

36 条记录 (耗时 0.013 秒)

    INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS
    31.
    发明公开
    INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS 失效
    吲哚衍生物治疗骨质疏松症

    公开(公告)号：EP0912560A1

    公开(公告)日：1999-05-06

    申请号：EP97932816.0

    申请日：1997-07-07

    申请人： Smithkline Beecham S.p.A. ,  SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES

    发明人： FARINA, Carlo ,  NADLER, Guy, Marguerite, Marie, Gérard ,  SENECI, Pierfausto SmithKline Beecham

    IPC分类号： A61K31 ,  A61P19 ,  A61P31 ,  A61P35 ,  C07D403 ,  C07D405 ,  C07D417

    CPC分类号： C07D403/06 ,  C07D405/06 ,  C07D417/06

    摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: R2, R3 and R4 each independently represents hydrogen, alkyl, aryl or substituted aryl; R5 represents hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represents hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R6 and R7 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; R8 represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl; and Z1 and Z2 together with the carbon atom to which they are attached represent a heterocyclic group; a pharmaceutical composition comprising such a compound, a process for preparing such a compound and the use of such compound in medicine.

    摘要翻译： 式（I）化合物或其盐或其溶剂化物，其中：R2，R3和R4各自独立地表示氢，烷基，芳基或取代的芳基; R5代表氢，烷基，芳基或取代的芳基; R6和R7各自独立地代表氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧羰基，氨基甲酰基， 亚甲二氧基，羰基二氧基或羰基二氨基; R8代表氢，羟基，烷酰基，烷基，氨基烷基，羟基烷基，羧基烷基，烷氧基烷基，氨基甲酰基或氨基磺酰基; 并且Z 1和Z 2与它们所连接的碳原子一起表示杂环基团; 包含该化合物的药物组合物，制备该化合物的方法以及该化合物在药物中的用途。