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39 条记录 (耗时 0.023 秒)

    Optineurin-derived polypeptides, their nucleic acids and uses thereof
    36.
    发明公开
    Optineurin-derived polypeptides, their nucleic acids and uses thereof 审中-公开
    Optineurinabgeleitete Polypeptide，derenNucleinsäurenund Verwendungen davon

    公开(公告)号：EP2606907A1

    公开(公告)日：2013-06-26

    申请号：EP11306702.9

    申请日：2011-12-19

    申请人： Institut Pasteur ,  Centre National de la Recherche Scientifique ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

    发明人： Weil, Robert, Serge ,  Kachaner, David ,  Côrte-Real Filipe, Josina ,  Laplantine, Emmanuel, François ,  Israël, Alain

    IPC分类号： A61K38/17 ,  C07K14/435

    CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/23 ,  C07K2319/24 ,  C12Q1/485 ,  G01N33/5008 ,  G01N33/574 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/168 ,  G01N2800/2835

    摘要： The invention relates to Optineurin-derived polypeptide(s) consisting of a polypeptidic sequence disclosed in SEQ ID N°2, which represents the portion of the wild-type human Optineurin protein sequence from its amino-acid residue 131 to its amino-acid residue 297, or having a polypeptidic sequence encompassing the polypeptidic sequence disclosed in SEQ ID N°2, or having a polypeptidic sequence derived from the polypeptidic sequence disclosed in SEQ ID N°2 to the exclusion of the wild-type Optineurin protein. The polypeptide(s) of the invention retain one, any combination of two, or three of the following functional properties: the capacity to bind Rab8 protein, when the latter are associated with the Golgi apparatus of a cell, the capacity to bind MYPT1 protein, when said protein is engaged in a Myosin-Phosphatase (MP) complex, the capacity to be phosphorylated by Plk1. The invention also relates to nucleic acid molecule(s) encoding such polypeptide(s), vector(s) and method(s) of production thereof, as well as uses thereof, in particular uses in treating cancer(s) or in treating a disease involving mitosis deregulation(s) or alteration(s).

    摘要翻译： 本发明涉及由SEQ ID NO：2中公开的多肽序列组成的Optineurin衍生多肽，其代表野生型人神经氨酸蛋白序列从其氨基酸残基131到其氨基酸残基的部分 297，或具有包含SEQ ID NO：2中公开的多肽序列的多肽序列，或具有衍生自SEQ ID NO：2所公开的多肽序列的多肽序列以排除野生型Optineurin蛋白质。 本发明的多肽保留一个，以下功能特性中的两个或三个的任何组合：当Rab8蛋白与细胞的高尔基体相关联时结合Rab8蛋白的能力，结合MYPT1蛋白的能力 当所述蛋白质参与肌球蛋白 - 磷酸酶（MP）复合物时，由Plk1磷酸化的能力。 本发明还涉及编码这些多肽，其载体及其生产方法的核酸分子，以及其用途，特别是治疗癌症或治疗癌症的用途 涉及有丝分裂放松管制或改变的疾病。

    High MAST2-affinity polypeptides and uses thereof
    37.
    发明公开
    High MAST2-affinity polypeptides and uses thereof 有权
    多肽线虫MAST2-Affinitätund deren Verwendungen

    公开(公告)号：EP2592091A1

    公开(公告)日：2013-05-15

    申请号：EP11306454.7

    申请日：2011-11-08

    申请人： Institut Pasteur ,  Centre National de la Recherche Scientifique ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

    发明人： Prehaud, Christophe ,  Lafon, Monique ,  Wolff, Nicolas ,  Khan, Zakir ,  Terrien, Elouan

    IPC分类号： C07K14/435

    CPC分类号： C12Q1/6883 ,  C07K14/005 ,  C07K14/435 ,  C07K2319/02 ,  C07K2319/05 ,  C07K2319/70 ,  C12N7/00 ,  C12N2799/027 ,  C12Q1/70 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5023 ,  G01N33/5038 ,  G01N33/5058 ,  G01N2333/705

    摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.

    摘要翻译： 本发明涉及含有以MAST-2结合结构域结束的细胞质结构域的多肽，其为11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L 所述多肽对人MAST2蛋白的PDZ结构域具有高亲和力。 本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及包含其的组合物。 本发明还涉及使用所述多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物来治疗和/或预防疾病，病症或病症，其改变中枢神经系统（CNS）和/或 外周神经系统（PNS）。 本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。