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公开(公告)号：EP0760811A1
公开(公告)日：1997-03-12
申请号：EP96908172.0
申请日：1996-03-21
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , QUEMENER, Agnès , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , PURAND, Katja , HÜLS, Annette , REIDEMEISTER, Sybille , ATHMANI, Salah , GANELLIN, Charon, Robin , PELLOUX-LEON, Nadia , TERTIUX, Wasyl , KRAUSE, Michael, C., O. , BASSEM, Sadek
IPC分类号： G01N33 , A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D233 , C07D401 , C07D405 , C07D409 , C07D411 , C07D413
CPC分类号： C07D233/56 , C07D233/64 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , G01N33/567 , G01N33/74 , G01N2333/726
摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.
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公开(公告)号：EP4248969A1
公开(公告)日：2023-09-27
申请号：EP22305343.0
申请日：2022-03-23
申请人： Bioprojet
IPC分类号： A61K31/4453 , A61P25/00
摘要： The present invention concerns the treatment of severe fatigue (SF), in particular in patients suffering from narcolepsy, comprising the administration of pitolisant or its pharmaceutically acceptable salts, such as the monohydrochloride salt at high doses.
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33.发明公开
公开(公告)号：EP3601252A1
公开(公告)日：2020-02-05
申请号：EP18711350.1
申请日：2018-03-20
申请人： Bioprojet
IPC分类号： C07D401/12 , A61K31/4545
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35.发明授权
公开(公告)号：EP1863487B2
公开(公告)日：2019-07-17
申请号：EP06744466.1
申请日：2006-03-30
申请人： BIOPROJET
IPC分类号： A61K31/4453 , A61P25/16 , A61P25/28
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公开(公告)号：EP2018158B1
公开(公告)日：2013-04-24
申请号：EP07731453.2
申请日：2007-05-14
申请人： BIOPROJET
IPC分类号： A61K9/20 , A61K9/28 , A61K31/223 , A61P1/12
CPC分类号： A61K9/2077 , A61K9/2813 , A61K9/284 , A61K9/2853 , A61K31/137 , A61K31/223
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37.发明公开NOVEL PHARMACEUTICALLY ACCEPTABLE SALTS OF 4-(1H-IMIDAZOL-4-YLMETHYL)PYRIDINE AND THEIR THERAPEUTICAL USES 审中-公开吡啶4-（1H-咪唑-4-基甲基）新的药学上可接受的盐和它们的治疗用途
公开(公告)号：EP2432469A1
公开(公告)日：2012-03-28
申请号：EP10721149.2
申请日：2010-05-18
申请人： BIOPROJET
发明人： CAPET, Marc , LABEEUW, Olivier , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , LIGNEAU, Xavier , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles
IPC分类号： A61K31/4439 , C07D401/06 , A61P25/00
CPC分类号： A61K31/4439
摘要： The present invention concerns novel pharmaceutical compositions of immethridine, in particular of novel pharmaceutically acceptable salts thereof, such as the dioxalate salt of immethridine, as well as its therapeutical uses and novel process of preparation.
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38.发明授权ASSOCIATION D'UN ANTAGONISTE OU AGONISTE INVERSE DU RECEPTEUR H3 DE L'HISTAMINE AVEC UN ANTI-PSYCHOTIQUE OU UN ANTIDEPRESSEUR ET SON UTILISATION POUR PREPARER UN MEDICAMENT PREVENANT DES EFFETS INDESIRABLES DE MEDICAMENTS PSYCHOTROPES 有权WITH A拮抗剂或组胺受体H3和抗精神病或抗抑郁剂的反向激动剂，其使用用于制备药物中的预防精神药物产生不利影响的组合产物
公开(公告)号：EP1641461B1
公开(公告)日：2010-09-29
申请号：EP04767475.9
申请日：2004-06-25
申请人： BIOPROJET
IPC分类号： A61K31/551 , A61K31/513 , A61K31/554 , A61K31/55 , A61K31/137 , A61K31/4412 , A61K31/496 , A61P25/24 , A61P25/18 , A61K31/40 , A61K31/4025
CPC分类号： A61K31/5513 , A61K31/137 , A61K31/4164 , A61K31/4412 , A61K31/4453 , A61K31/496 , A61K31/513 , A61K31/55 , A61K31/551 , A61K31/554 , A61K45/06
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39.发明公开ASSOCIATION D'UN ANTAGONISTE OU AGONISTE INVERSE DU RECEPTEUR H3 DE L'HISTAMINE AVEC UN ANTI-PSYCHOTIQUE OU UN ANTIDEPRESSEUR ET SON UTILISATION POUR PREPARER UN MEDICAMENT PREVENANT DES EFFETS INDESIRABLES DE MEDICAMENTS PSYCHOTROPES 有权WITH A拮抗剂或组胺受体H3和抗精神病或抗抑郁剂的反向激动剂，其使用用于制备药物中的预防精神药物产生不利影响的组合产物
公开(公告)号：EP1641461A1
公开(公告)日：2006-04-05
申请号：EP04767475.9
申请日：2004-06-25
申请人： BIOPROJET
IPC分类号： A61K31/551 , A61K31/513 , A61K31/554 , A61K31/55 , A61K31/137 , A61K31/4412 , A61K31/496 , A61P25/24 , A61P25/18 , A61K31/40 , A61K31/4025
CPC分类号： A61K31/5513 , A61K31/137 , A61K31/4164 , A61K31/4412 , A61K31/4453 , A61K31/496 , A61K31/513 , A61K31/55 , A61K31/551 , A61K31/554 , A61K45/06
摘要： The invention relates to a medicament which comprises, in a pharmaceutically-acceptable vehicle, an antipsychotic agent or an antidepressant agent (A), the only adverse effect thereof being weight gain or sedation, and an antagonist and/or inverse agonist (B) of histamine receptor H3, said antagonist and/or inverse agonist of histamine receptor H3 being present in a therapeutically-effective quantity such as to provide at least one of the following three effects: suppression or at least limitation of the adverse weight gain effect, suppression or limitation of the adverse effect on vigilance, epilepsy/convulsions, increase in the pro-cognitive effect of the treatment. The invention also relates to one such antagonist or inverse agonist for the preparation of a medicament that is intended to provide at least one of the aforementioned effects in a patient being treated with one such antipsychotic or antidepressant agent
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公开(公告)号：EP1165491B1
公开(公告)日：2004-02-11
申请号：EP00917145.5
申请日：2000-04-06
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , PIETTRE, Serge
IPC分类号： C07C229/12 , C07F9/38 , A61P29/00
CPC分类号： C07F9/3808 , C07C45/30 , C07C47/277 , C07C229/08 , C07C251/02 , C07F9/4006
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