摘要:
A cooling system (1), especially for cryopreserving biological samples (2), comprises a cooling chamber (100) delimited by a bottom area (110), side walls (120), and a top area (130), and a cooling device (200) for cooling the cooling chamber (100) using liquid nitrogen (220). The bottom area (110) is designed for direct cooling using the liquid nitrogen, and the cooling chamber (100) is dimensioned such that an operator (3) can access and move around in the cooling chamber (100). The bottom area (110) has a platform (111) which is permeable to vapor of the liquid nitrogen (220) and forms a support zone for the operator (3). Methods for operating the cooling system are also described.
摘要:
The invention relates to a method for monitoring a cryopreserved biological sample (1), comprising the steps of providing the biological sample (1) in a cryopreserved state, measuring at least one Raman spectroscopic sample characteristic by means of a Raman spectroscopic measuring apparatus (10, 20), comparing the at least one sample characteristic with a reference characteristic by means of an evaluating apparatus (30), and providing a state characteristic that depends on the result of the comparison and that is characteristic of a storage state of the biological sample (1). The invention further relates to a monitoring device for cryopreserved samples, in particular for performing said method.
摘要:
The invention relates to a cryo-substrate, especially for the cryoconservation of biological samples, containing at least one solid-phase element which is directed at adherent fixing of said sample. The solid-phase element comprises at least one support filament. The invention also relates to a method for the cryoconservation of biological samples using one such cryo-substrate.
摘要:
The invention relates to a method for producing a plurality of frozen biological particles (1) which are suitable for deposition in biological material. Said method comprises the following steps: making available a liquid suspension having a cellular component (3, 3.1 – 3.10) which comprises at least one of the following: at least one biological cell, at least one cell group and at least one cell component, receiving subportions (2) of the suspension in receiving elements (12) of a carrier device (11), cooling the carrier device (10) and freezing the subportions of the suspension, thereby forming the frozen biological particles (1) having an interior shape and interior size of the receiving elements, and separating the frozen biological particles (1) from the receiving elements (12). The invention also relates to a freezing device (100) which is designed to produce a plurality of frozen biological particles.
摘要:
The invention relates to a method for moving a probe (10, 91) through cell material (20) which is formed from biological cells (21). The probe (10) displaces the cells (21) in a non-traumatic manner. The invention also relates to a probe (10, 91) for carrying out said method and to a cell manipulator which is fitted with at least one probe of said type.
摘要:
A cryopreservation storage device (100), in particular for cryopreservation of biological samples, comprises a plurality of multi sample modules (20) being adapted for accommodating the biological samples and sample memories, a module control device (30) controlling an access to sample memories accommodated by the multi sample modules (20) , and a data interface (41) for accessing to the module control device (30), wherein the module control device (30) includes a data management processor (31), which can be controlled via the data interface (41) . Furthermore, a cryopreservation apparatus including at least one cryopreservation storage device (100) and a method for cryopreservation of biological samples are described.