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公开(公告)号：EP2952509A1
公开(公告)日：2015-12-09
申请号：EP13874396.8
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D263/26 , A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , A61K31/421 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
摘要翻译： 本发明涉及式I化合物及其制备方法和用途。 该化合物具有细菌感染调节作用，可用于预防和/或治疗由细菌感染引起的疾病。
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公开(公告)号：EP3485887A1
公开(公告)日：2019-05-22
申请号：EP17826908.0
申请日：2017-07-04
发明人： ZHONG, Wu , YANG, Meiyan , GONG, Wei , WANG, Yuli , GAO, Chunsheng , ZHOU, Xinbo , LI, Song
IPC分类号： A61K31/403 , A61K47/18 , A61K9/08 , A61K9/19 , A61P31/20
摘要： The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
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公开(公告)号：EP3006431B1
公开(公告)日：2019-01-30
申请号：EP14820360.7
申请日：2014-07-04
发明人： LI, Song , LI, Xingzhou , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai , ZHOU, Xinbo , XIE, Yunde , WANG, Xiaokui , WANG, Lili , CHEN, Wei , XIE, Fei
IPC分类号： C07D277/58 , C07D417/12 , A61K31/426 , A61K31/454 , A61K31/496 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61P31/20 , A61P31/14 , A61P31/16 , A61P31/04 , A61P33/02 , A61P33/10 , C07F9/6539
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公开(公告)号：EP3424913A1
公开(公告)日：2019-01-09
申请号：EP17759268.0
申请日：2017-03-02
发明人： LI, Song , XIAO, Junhai , ZHANG, Xiaoye , WANG, Hongliang , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D303/48 , C07D301/00 , C07D405/12 , A61K31/336 , A61K31/4523 , A61K31/4025 , A61K31/5377 , A61K31/541 , A61K31/427 , A61P35/00
摘要： The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma.
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公开(公告)号：EP3085700B1
公开(公告)日：2018-10-31
申请号：EP14871647.5
申请日：2014-12-19
发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui
IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , A61K31/506 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/04
CPC分类号： C07D401/04 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D409/14 , A61K2300/00
摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
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36.发明授权PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252B1
公开(公告)日：2016-05-04
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
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37.发明公开
公开(公告)号：EP3006432A1
公开(公告)日：2016-04-13
申请号：EP14804849.9
申请日：2014-05-28
发明人： LI, Song , XIAO, Junhai , ZHANG, Xian , ZHONG, Wu , ZHENG, Zhibing , WANG, Lili , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D303/48 , C07D301/00 , C07D417/12 , C07D417/14 , A61K31/336 , A61K31/427 , A61K31/428 , A61P31/14 , A61P31/16
CPC分类号： C07D417/12 , C07D303/48 , C07D417/14
摘要： Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.
摘要翻译： 提供了可用作针对小RNA病毒感染的药物的式I化合物及其光学异构体，药学上可接受的盐，溶剂化物或水合物。 还提供了该化合物的制备方法，该化合物用于治疗细菌感染的方法以及该化合物在制备用于预防和/或治疗由小RNA病毒引起的病毒性疾病的药物中的用途。
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38.发明公开TIZOXANIDE CARBAMATE AND PHARMACEUTICAL USE THEREOF 审中-公开TIZOXANIDCARBAMAT UND PHARMAZEUTISCHE VERWENDUNG DAVON
公开(公告)号：EP3006431A1
公开(公告)日：2016-04-13
申请号：EP14820360.7
申请日：2014-07-04
发明人： LI, Song , LI, Xingzhou , ZHONG, Wu , ZHENG, Zhibing , XIAO, Junhai , ZHOU, Xinbo , XIE, Yunde , WANG, Xiaokui , WANG, Lili , CHEN, Wei , XIE, Fei
IPC分类号： C07D277/58 , C07D417/12 , A61K31/426 , A61K31/454 , A61K31/496 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61P31/20 , A61P31/14 , A61P31/16 , A61P31/04 , A61P33/02 , A61P33/10 , C07F9/6539
CPC分类号： C07D277/58 , C07D401/12 , C07D417/12
摘要： The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their pharmaceutical use.
摘要翻译： 本发明涉及式I的替佐尼特氨基甲酸酯化合物及其药学上可接受的盐，水合物或溶剂合物及其药物用途。
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39.发明公开DERIVATIVE OF HOMOSERINE LACTONE, AND PREPARATION METHOD AND USE THEREOF 审中-公开DERIVAT VON HOMOSERINLACTON SOWIE HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
公开(公告)号：EP2955174A1
公开(公告)日：2015-12-16
申请号：EP13874809.0
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
CPC分类号： C07D307/33 , A61K31/365 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： Disclosed are a derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
摘要翻译： 公开了由式I表示的高丝氨酸内酯的衍生物及其制备方法和用途。 该化合物具有细菌感染调节作用，可用于预防和/或治疗由细菌感染引起的疾病。
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40.发明公开
公开(公告)号：EP2889293A1
公开(公告)日：2015-07-01
申请号：EP12883262.3
申请日：2012-08-24
发明人： LI, Song , XIAO, Junhai , HAN, Dan , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui , JIANG, Dan , CHEN, Wei , LIU, Hongying
CPC分类号： C07D279/12
摘要： The present invention relates to a thiazine amide derivative and a pharmaceutical use thereof, and particularly to a compound of formula I (in the formula, variables are as described in the specification), a pharmaceutically acceptable salt, solvate or hydrate thereof. The present invention further relates to a method for preparing the compound, a pharmaceutical composition containing the compound, and a method or use thereof for prevention or treatment of neurodegenerative diseases.
摘要翻译： 本发明涉及噻嗪酰胺衍生物及其药物用途，特别涉及式I（式中，变量如说明书中所述）的化合物，其药学上可接受的盐，溶剂化物或水合物。 本发明进一步涉及用于制备该化合物的方法，含有该化合物的药物组合物，及其用于预防或治疗神经退行性疾病的方法或用途。
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