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公开(公告)号：EP1309677B1
公开(公告)日：2008-07-09
申请号：EP01957519.0
申请日：2001-08-10
发明人： DIAZ-TORRES, Maria, R. , SCHELLENBERGER, Volker , SELIFONOVA, Olga, V. , MORRISON, Thomas, B. , LEE, Edwin, W.
IPC分类号： C12N15/00
CPC分类号： C12N15/902 , C12N15/102 , C12N15/90
摘要： The present invention provides methods for building DNA constructs in vitro, transforming such constructs into competent Bacillus strains with good efficiency, and generating populations of mutants. Also provided is a method to assemble DNA constructs in situ.
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公开(公告)号：EP1691763A2
公开(公告)日：2006-08-23
申请号：EP04813700.4
申请日：2004-12-10
IPC分类号： A61K6/00
CPC分类号： C07K16/3007 , A61K2039/505 , C07K16/40 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in diagnosis and therapy.
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公开(公告)号：EP1549663A2
公开(公告)日：2005-07-06
申请号：EP03724548.7
申请日：2003-05-12
发明人： CHEN, Yiyou , DAY, Anthony, G. , EDWARDS, Cynthia , MURRAY, Christopher, J. , SCHELLENBERGER, Volker
IPC分类号： C07K1/00
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/6415 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C07K2319/50 , C07K2319/55 , C07K2319/70 , C12N9/50 , C12N9/86 , C12N15/1044 , C12N15/62
摘要： The present invention provides methods and compositions relating to polypeptides engineered to bind a target and have at least two functional domains.
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34.发明公开MUTANT E. COLI APPA PHYTASE ENZYMES AND NATURAL VARIANTS THEREOF, NUCLEIC ACIDS ENCODING SUCH PHYTASE ENZYMES, VECTORS AND HOST CELLS INCORPORATING SAME AND METHODS OF MAKING AND USING SAME 有权大肠杆菌突变株APPA植酸酶的酶和天然变异物，例如肌醇六磷酸酶的核酸编码，将含有载体和宿主细胞AND METHOD FOR PRODUCTION及其用途
公开(公告)号：EP1546316A2
公开(公告)日：2005-06-29
申请号：EP03785159.9
申请日：2003-08-11
发明人： BLATTMANN, Beat, O. , DARZINS, Aldis , DAVIS, John, M. , ENCELL, Lance, P. , MORRISON, Thomas, B. , MRACHKO, Gregory, T. , SCHELLENBERGER, Volker
CPC分类号： C12N15/8243 , C12N9/16 , C12N15/8245
摘要： Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.
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公开(公告)号：EP1341908A2
公开(公告)日：2003-09-10
申请号：EP01991147.8
申请日：2001-12-14
IPC分类号： C12N9/86
摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
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公开(公告)号：EP1042501A2
公开(公告)日：2000-10-11
申请号：EP98966092.3
申请日：1998-12-23
发明人： SCHELLENBERGER, Volker , NAKI, Donald, P. , COLLIER, Katherine, D. , KELLIS, James, T., Jr. , NADHERNY, Joanne
IPC分类号： C12Q1/00
CPC分类号： C12Q1/00
摘要： An improved method for assaying the wash performance of new enzymes and/or new detergent formulations by comparing performance of enzyme cleaning effectiveness on washed soiled swatch cloths.
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37.发明公开MULTIPLY-SUBSTITUTED PROTEASE VARIANTS WITH ALTERED NET CHARGE FOR USE IN DETERGENTS 无效多的取代的蛋白酶变种改进净电荷用于洗涤剂
公开(公告)号：EP1025240A2
公开(公告)日：2000-08-09
申请号：EP98955111.4
申请日：1998-10-23
发明人： POULOSE, Ayrookaran, J. , SCHELLENBERGER, Volker , KELLIS, James, T., Jr. , PAECH, Christian , NADHERNY, Joanne , NAKI, Donald, P. , CALDWELL, Robert, M. , COLLIER, Katherine, D.
CPC分类号： C12N9/54 , A23G4/123 , A23K20/189 , A61K8/66 , A61K2800/86 , A61Q11/00 , A61Q19/00 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/3907 , C11D3/3945 , C12Y304/00 , C12Y304/21062
摘要： Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Protease variants are provided that contain substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more negative or less positive compared to a precursor protease and thus the protease variant is more effective in a low detergent concentration system than a precursor protease. Also provided are protease variants containing substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more positive or less negative compared to a precursor protease and thus the protease variant is more effective in a high detergent concentration system than a precursor protease.
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公开(公告)号：EP1027418B2
公开(公告)日：2011-01-19
申请号：EP98955109.8
申请日：1998-10-23
发明人： GHOSH, Chanchal, Kumar , BAECK, Andre, Cesar , OHTANI, Ryohei , BUSCH, Alfred , SHOWELL, Michael, Stanford , SCHELLENBERGER, Volker , KELLIS, James, T., Jr. , PAECH, Christian , NADHERNY, Joanne , NAKI, Donald, P. , COLLIER, Katherine, D. , CALDWELL, Robert, M. , POULOSE, Ayrookaran, J.
CPC分类号： C12N9/54 , A23G4/123 , A23K20/189 , A61K8/66 , A61K2800/86 , A61Q11/00 , A61Q19/00 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/3907 , C11D3/3945 , C12Y304/00 , C12Y304/21062
摘要： The present invention relates to cleaning compositions comprising a protease variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin; and one or more cleaning adjunct materials. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of $(Bacillus amyloliquefaciens) subtilisin; and one or more cleaning adjunct materials. Methods for using the cleaning compositions are also provided.
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公开(公告)号：EP1512015B1
公开(公告)日：2009-03-25
申请号：EP03760249.7
申请日：2003-06-09
CPC分类号： C40B30/04 , C12N15/1086 , C12Q1/6897 , G01N33/53 , G01N33/54306 , G01N33/581 , G01N33/6845
摘要： The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced by the methods of the present invention.
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40.发明授权
公开(公告)号：EP1025194B1
公开(公告)日：2008-12-10
申请号：EP98955079.3
申请日：1998-10-23
发明人： GHOSH, Chanchal, Kumar , BAECK, Andre, Cesar , OHTANI, Ryohei , BUSCH, Alfred , SHOWELL, Michael, Stanford , SCHELLENBERGER, Volker , KELLIS, James, T., Jr. , PAECH, Christian , NADHERNY, Joanne , NAKI, Donald, P. , COLLIER, Katherine, D. , CALDWELL, Robert, M. , POULOSE, Ayrookaran, J.
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , A23G4/123 , A23K20/189 , A61K8/66 , A61K2800/86 , A61Q11/00 , A61Q19/00 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/3907 , C11D3/3945 , C12Y304/00 , C12Y304/21062
摘要： The present invention relates to bleaching compositions comprising a protease variant. One bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274, and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues at positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265, or 274 of Bacillus amyloliquefaciens subtilisin, a bleaching agent; and one or more cleaning adjunct materials. Another bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of Bacillus amyloliquefaciens subtilisin; a bleaching agent; and one or more cleaning adjunct materials. Methods for using the bleaching compositions are also provided.
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