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公开(公告)号：EP2702154A1
公开(公告)日：2014-03-05
申请号：EP12776541.0
申请日：2012-04-27
申请人： Codexis, Inc.
发明人： VOLADRI, Rama , ZHANG, Xiyun , PATIL, Sachin , ELGART, David , MILLER, Gregory , CLARK, Louis , CHAN, Kui
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/2434 , C12P19/02 , C12P19/14
摘要： The present invention relates to cellobiohydrolase variants having improved thermostability and/or thermoactivity in comparison to wild-type
Myceliophthora thermophila CBH2b.摘要翻译： 本发明涉及与野生型嗜热毁丝霉CBH2b相比具有改善的热稳定性和/或热活性的纤维二糖水解酶变体。
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32.发明公开RECOMBINANT LIGNOCELLULOSE DEGRADATION ENZYMES FOR THE PRODUCTION OF SOLUBLE SUGARS FROM CELLULOSIC BIOMASS 审中-公开重组木质纤维素清除酶可溶性糖的纤维素生物质制备
公开(公告)号：EP2609195A4
公开(公告)日：2014-03-05
申请号：EP11820468
申请日：2011-08-22
申请人： CODEXIS INC
发明人： CLARK LOUIS , BAIDYAROY DIPNATH
CPC分类号： C12N9/2402 , C12N9/0004 , C12N9/16 , C12N9/2437 , C12P19/00 , C12P19/14
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33.发明授权RECOMBINANT BETA-GLUCOSIDASE VARIANTS FOR PRODUCTION OF SOLUBLE SUGARS FROM CELLULOSIC BIOMASS 有权重组β-葡糖苷酶OPTIONS FOR可溶性糖从生物质的纤维素THE PRODUCTION
公开(公告)号：EP2504017B1
公开(公告)日：2014-01-08
申请号：EP10833977.1
申请日：2010-11-24
申请人： Codexis, Inc.
发明人： YANG, Jie , ZHANG, Xiyun , ANDOR, Attila
CPC分类号： C12N9/42 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , Y02E50/16
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公开(公告)号：EP2566497A4
公开(公告)日：2013-11-27
申请号：EP11778262
申请日：2011-05-04
申请人： CODEXIS INC
发明人： CROWE MICHAEL A , ALVIZO OSCAR , BEHROUZIAN BEHNAZ , BONG YONG KOY , COLLIER STEVEN J , GOHEL ANUPAM , MAVINAHALLI JAGADEESH , MODUKURU NAGA , MUNDORFF EMILY , SMITH DEREK , SONG SHIWEI , YEO WAN LIN
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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35.发明公开
公开(公告)号：EP2588597A2
公开(公告)日：2013-05-08
申请号：EP11801422.4
申请日：2011-06-30
申请人： Codexis, Inc.
发明人： NOVICK, Scott , ALVIZO, Oscar
IPC分类号： C12N9/00
CPC分类号： C12N9/96 , B01D53/1475 , B01D53/1493 , B01D53/84 , B01D2252/20484 , B01D2252/20489 , B01D2252/602 , B01D2255/804 , B01D2257/504 , B01D2258/0283 , C12N9/88 , Y02C10/06 , Y02P20/59
摘要： The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides methods of preparing the chemically modified polypeptides and methods of using the chemically modified polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering.
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公开(公告)号：EP2483293A4
公开(公告)日：2013-05-01
申请号：EP10821066
申请日：2010-09-24
申请人： CODEXIS INC
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：EP2483292A4
公开(公告)日：2013-05-01
申请号：EP10821065
申请日：2010-09-24
申请人： CODEXIS INC
发明人： GILSON LYNNE , COLLIER STEVEN JAMES , SUKUMARAN JOLY , YEO WAN LIN , ALVISO OSCAR , TEO EE LING , WILSON ROBERT JOHN , XU JUNYE
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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公开(公告)号：EP2576804A1
公开(公告)日：2013-04-10
申请号：EP11787481.8
申请日：2011-05-27
申请人： Codexis, Inc.
CPC分类号： C12P19/24 , C12N9/90 , C12N9/92 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P2203/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译： 本发明提供了包含木糖异构酶多核苷酸的重组核酸构建体，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞以及相关方法。
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公开(公告)号：EP2467473A4
公开(公告)日：2013-03-20
申请号：EP10810597
申请日：2010-08-19
申请人： CODEXIS INC
发明人： ALVIZO OSCAR , COLLIER STEVEN J , HENNEMANN JOERG , OH SEONG HO , ZHA WENJUAN
IPC分类号： C12N9/02 , A61K31/137 , C12N15/53 , C12P13/00
CPC分类号： C12N9/0006 , A61K31/137 , C12P13/001 , C12Y101/01184
摘要： The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
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公开(公告)号：EP2382308A4
公开(公告)日：2012-08-29
申请号：EP09835878
申请日：2009-12-23
申请人： CODEXIS INC
发明人： SAVILE CHRISTOPHER , MITCHELL VESNA , ZHANG XIYUN , HUISMAN GJALT
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
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