公开(公告)号：EP1296726A2

公开(公告)日：2003-04-02

申请号：EP01948706.5

申请日：2001-06-27

申请人： Osteotech, Inc.,

发明人： BOYCE, Todd, M. ,  KAES, David ,  SCARBOROUGH, Nelson, L.

IPC分类号： A61L27/36

CPC分类号： A61F2/28 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02

摘要： An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32 % and a method of making an osteogenic osteoimplant having not greater than about 32 % void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.

公开(公告)号：EP1280564A2

公开(公告)日：2003-02-05

申请号：EP01935499.2

申请日：2001-05-14

申请人： Osteotech, Inc.,

发明人： EDWARDS, Jean, T. ,  SHIMP, Lawrence, A. ,  DIEGMANN, Michele ,  BOYCE, Todd, M. ,  SCARBOROUGH, Nelson, L. ,  RUSSELL, James, L.

IPC分类号： A61L27/36

CPC分类号： A61L27/3683 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02

摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

公开(公告)号：EP1204386A4

公开(公告)日：2002-09-18

申请号：EP00938225

申请日：2000-06-08

申请人： OSTEOTECH INC

发明人： BOYLE JOHN W ,  SHIMP LAWRENCE A ,  KAES DAVID R ,  MORRIS JOHN W ,  MARTZ ERIK O ,  BOYCE TODD M ,  DAUGHERTY MARK

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46

CPC分类号： A61F2/4611 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/4465 ,  A61F2/447 ,  A61F2002/2817 ,  A61F2002/2825 ,  A61F2002/2835 ,  A61F2002/30112 ,  A61F2002/30115 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30158 ,  A61F2002/3023 ,  A61F2002/30235 ,  A61F2002/30238 ,  A61F2002/30266 ,  A61F2002/3028 ,  A61F2002/30324 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/3082 ,  A61F2002/30836 ,  A61F2002/30843 ,  A61F2002/30904 ,  A61F2002/30952 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4649 ,  A61F2230/0004 ,  A61F2230/0006 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0026 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0036 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00131 ,  A61F2310/00293 ,  A61F2310/00359

摘要： A ramp-shaped intervertebral implant (10) is disclosed. The implant has a body having a first end (16), a second end (14), a top surface (22) and a bottom surface (24). At least one of the top and bottom surfaces is tapered that converges towards the second end of the body. An opening (26) extends through the body, has one end opening onto the top surface of the implant and the other end opening onto the bottom surface of the implant. The implant can be formed from the diaphysis or metaphysis of a long bone, wherein the intramedullary canal of the long bone defines the opening. Alternately, the implant can be made from any biocompatible material having the requisite strength requirement.

摘要翻译： 公开了一种斜坡形椎间植入物（10）。 植入物具有主体，该主体具有第一端部（16），第二端部（14），顶部表面（22）和底部表面（24）。 顶面和底面中的至少一个是渐缩的，朝向主体的第二端会聚。 开口（26）延伸穿过主体，其一端开口到植入物的顶表面上，另一端开口到植入物的底表面上。 植入物可以由长骨的骨干或干骺端形成，其中长骨的髓内管限定开口。 或者，植入物可以由具有所需强度要求的任何生物相容性材料制成。

公开(公告)号：EP1194086A1

公开(公告)日：2002-04-10

申请号：EP00938203.7

申请日：2000-06-08

申请人： Osteotech, Inc.,

发明人： BOYCE, Tood, M. ,  MARTZ, Erik, O. ,  SCARBOROUGH, Nelson, L.

IPC分类号： A61F2/44

CPC分类号： A61F2/4455 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2825 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30125 ,  A61F2002/30153 ,  A61F2002/3021 ,  A61F2002/30224 ,  A61F2002/30261 ,  A61F2002/3028 ,  A61F2002/30354 ,  A61F2002/30772 ,  A61F2002/30774 ,  A61F2002/30789 ,  A61F2002/3082 ,  A61F2002/30858 ,  A61F2002/30868 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2002/4649 ,  A61F2220/0033 ,  A61F2230/0008 ,  A61F2230/0019 ,  A61F2230/0063 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2240/001 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00131 ,  A61F2310/00161 ,  A61F2310/00179 ,  A61F2310/00293

摘要： An intervertebral implant (50) having a tabbed configuration is provided. The intervertebral implant includes a substantially cylindrical body portion (52), and a pair of radially extending tabs (62, 64). The radially extending tabs may be provided as a single or double pair (66, 68), may assume various shapes, and configurations for engaging the interior of a bore (E) formed between adjacent vertebrae (X, Y). A through bore (60) or plurality of through bores extend from the top surface (58) of the implant to the bottom surface (70) of the implant. The implant may be formed from a cortical ring (C) cut from the diaphysis of a long bone (D) by milling. Alternatively, the implant may be formed of any biocompatible material having the requisite strength requirements via any known process, i.e., molding. There is also disclosed a method of insertion of the implant including forming a stepped bore between adjacent vertebrae, inserting the implant between adjacent vertebrae with tabs in alignment with the spaced defined by the adjacent vertebrae, and rotating the implant such that the tabs are rotated within an enlarged or stepped portion of the bore to secure it therein.

公开(公告)号：EP1014900A1

公开(公告)日：2000-07-05

申请号：EP97942528.7

申请日：1997-09-17

申请人： Osteotech, Inc.,

发明人： SCARBOROUGH, Nelson ,  MORRIS, John, W.

IPC分类号： A61F2/44

CPC分类号： A61F2/447 ,  A61F2/446

摘要： An intervertebral prosthesis includes a bone graft implant member dimensioned for insertion within an intervertebral space defined between adjacent vertebrae and having at least first and second longitudinal sections with respective first and second cross-sectional dimensions. The first cross-sectional dimension of the first implant section is greater than the second cross section dimension of the second implant section to define a stepped region having a retaining surface. Consequently, upon insertion of the implant member within a generally correspondingly dimensioned receiving bed formed within the adjacent vertebrae, the retaining surface facilitates securement therewithin by corresponding engagement with surfaces of the receiving bed. A method for fusion of adjacent vertebrae utilizing the prosthesis is also disclosed.

公开(公告)号：EP0740555A4

公开(公告)日：2000-04-05

申请号：EP95910113

申请日：1995-01-23

申请人： OSTEOTECH INC

发明人： MORSE BRENDA SMITH ,  DIOH CLEMENT D

IPC分类号： A61K33/18 ,  A61F2/28 ,  A61F2/46 ,  A61L2/00 ,  A61L2/16 ,  A61L27/36 ,  A61L33/00

CPC分类号： A61L27/3691 ,  A61F2/28 ,  A61F2/4644 ,  A61F2002/2825 ,  A61F2002/2828 ,  A61F2002/2839 ,  A61F2002/4646 ,  A61K35/32 ,  A61L2/0088 ,  A61L27/36 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2430/02 ,  Y10S623/923

摘要： A method of preparing bone for transplantation in which the internal matrix of the bone is contacted with an atmosphere at less than ambient pressure. The method may additionally, include a further step in which the bone is maintained in contact with a decontaminating agent or a detergent during the period of contact with the atmosphere.

公开(公告)号：EP0413492B1

公开(公告)日：1997-11-26

申请号：EP90308655.1

申请日：1990-08-07

申请人： OSTEOTECH, INC.,

发明人： Lyle, John W.

IPC分类号： A61F2/30 ,  A61L27/00

CPC分类号： A61L27/3608 ,  A61F2/30767 ,  A61F2/3662 ,  A61F2002/30677 ,  A61F2310/00958 ,  A61L27/28 ,  A61L27/365 ,  A61L27/50 ,  A61L2430/02

公开(公告)号：EP0732947A1

公开(公告)日：1996-09-25

申请号：EP95904299.0

申请日：1994-12-08

申请人： OSTEOTECH, INC.

发明人： DOWD, Michael ,  DYKE, Denis, G.

IPC分类号： A61L27 ,  A61F2

CPC分类号： A61L27/3847 ,  A61F2/28 ,  A61F2002/2839 ,  A61F2002/30677 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695

摘要： Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.

公开(公告)号：EP0419275A1

公开(公告)日：1991-03-27

申请号：EP90310342.2

申请日：1990-09-21

申请人： OSTEOTECH, INC.,

发明人： O'Leary, Robert K. ,  McBrayer, Patrick A.

IPC分类号： A61L27/00 ,  A61L25/00

CPC分类号： A61L27/3608 ,  A61B17/686 ,  A61B17/82 ,  A61F2/2803 ,  A61F2/2846 ,  A61F2/4455 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30075 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2210/0061 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61K35/32 ,  A61L24/0005 ,  A61L27/227 ,  A61L27/365 ,  A61L27/3683 ,  A61L2400/06 ,  A61L2430/02 ,  Y10S514/801 ,  Y10S514/802 ,  Y10S514/953

摘要： A flowable demineralized bone powder composition is provided for use in surgical bone repair.

摘要翻译： 可流动的脱矿质的骨粉末组合物提供了用于在外科手术的骨修复中使用。

公开(公告)号：EP2254649A4

公开(公告)日：2011-04-20

申请号：EP08873572

申请日：2008-12-24

申请人： OSTEOTECH INC

发明人： WEI GUOBAO ,  BEHNAM KEYVAN ,  FORSYTH NANETTE ,  WINTERBOTTOM JOHN ,  BEISSER JAMES ,  BOYCE TODD M ,  ATTAWIA MOHAMED ,  RICHARDS CRISTY J ,  SHIMP LAWRENCE

IPC分类号： A61L24/00 ,  A61L27/56

CPC分类号： A61M35/00

摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.