公开(公告)号：EP2818543A1

公开(公告)日：2014-12-31

申请号：EP12869142.5

申请日：2012-11-29

申请人： Bloomage Freda Biopharm Co. Ltd.

发明人： GUO, Xueping ,  SHI, Yanli ,  QIAO, Liping ,  FENG, Ning ,  WANG, Guanfeng ,  LI, Haina ,  XUE, Wei ,  WANG, Haiying ,  LUAN,Yihong ,  LIU, Aihua

IPC分类号： C12N1/20 ,  C12N9/26 ,  C12N15/56 ,  C12P19/28 ,  C07K14/32 ,  A61K8/73 ,  A61K31/728 ,  A61P17/02 ,  A61P9/00 ,  A61Q17/00 ,  C12R1/07

CPC分类号： C12N9/2474 ,  A23L33/17 ,  A23V2002/00 ,  A61K8/66 ,  A61K8/735 ,  A61K31/728 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  C08B37/0072 ,  C12N9/2408 ,  C12P19/26 ,  C12P19/28 ,  C12R1/07 ,  Y02P20/52

摘要： The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines.

摘要翻译： 本发明提供芽孢杆菌属 存款号码为CGMCC NO。 5744和透明质酸酶产生的透明质酸酶和透明质酸酶的氨基酸序列示于SEQ ID NO：2中。本发明还涉及制备低聚透明质酸或其盐或低分子量透明质酸或 其通过使用由此产生的芽孢杆菌或透明质酸酶。 产生的低聚物透明质酸盐或低分子透明质酸酯具有良好的透皮吸收能力，高纯度，无细胞毒性，有效的抗氧化能力等优点。 本发明还提供了具有存取通道号CGMCC NO的芽孢杆菌的用途。 5744，或透明质酸酶，低聚物透明质酸盐或其盐，低分子量透明质酸盐或其盐，其由化妆品，食品和药物领域中的芽孢杆菌产生。

公开(公告)号：EP2802573A1

公开(公告)日：2014-11-19

申请号：EP13712949.0

申请日：2013-01-11

申请人： Regents of the University of Minnesota

发明人： VINCE, Robert ,  RAZA, Abbas ,  DREIS, Christine

IPC分类号： C07D403/12 ,  A61K31/506 ,  A61K31/519 ,  C07D487/04 ,  C07D487/16 ,  A61P17/00

CPC分类号： C07D239/22 ,  A61K8/4953 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  A61Q17/04 ,  A61Q19/004 ,  C07D403/12 ,  C07D487/04 ,  C07D487/16 ,  A61K2300/00

摘要： The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.

摘要翻译： 本发明提供了本文所述的式I化合物或其盐。 本发明还提供包含式I化合物或一种或多种式I化合物的混合物的皮肤病学组合物，用于制备式I化合物的方法，可用于制备式I化合物的中间体和用于保护皮肤或DNA免受光损伤的治疗方法或 修复光损伤的皮肤或DNA。

公开(公告)号：EP1185260B1

公开(公告)日：2014-10-15

申请号：EP00919421.8

申请日：2000-03-16

申请人： Bioderm, Inc.

发明人： MEISNER, Lorraine, F.

IPC分类号： A61K33/04 ,  A61K33/30 ,  A61P17/00 ,  A61K31/375 ,  A61K8/27 ,  A61Q19/08 ,  A61Q17/00 ,  A61K8/44 ,  A61K8/67 ,  A61K38/06

CPC分类号： A61Q17/00 ,  A61K8/27 ,  A61K8/44 ,  A61K8/447 ,  A61K8/676 ,  A61K31/375 ,  A61K33/30 ,  A61K38/06 ,  A61Q19/004 ,  A61Q19/08 ,  Y10S514/886 ,  Y10S514/887 ,  A61K31/195 ,  A61K31/19 ,  A61K31/70 ,  A61K2300/00

公开(公告)号：EP2656832A3

公开(公告)日：2014-08-06

申请号：EP12178381.5

申请日：2007-05-11

申请人： Regenics AS

发明人： Gammelsaeter, Runhild ,  Remmereit, Jan

IPC分类号： A61K8/97 ,  A61K8/98 ,  A61Q19/00 ,  A61P17/02 ,  A61F13/00 ,  A61K9/70 ,  A61K35/12 ,  A61K35/48 ,  A61K35/56 ,  A61K35/60 ,  A61K35/66 ,  A61K8/99 ,  A61Q19/08 ,  A61Q19/06 ,  A61K35/36 ,  A61K8/64 ,  A61K8/65

CPC分类号： A61K35/60 ,  A61K8/606 ,  A61K8/64 ,  A61K8/65 ,  A61K8/97 ,  A61K8/9706 ,  A61K8/981 ,  A61K8/982 ,  A61K8/987 ,  A61K8/99 ,  A61K31/7088 ,  A61K35/36 ,  A61K38/02 ,  A61K45/06 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/06 ,  A61Q19/08

摘要： The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. This invention relates to the use of cells and cellular extracts in rejuvenation and healing technologies thereby improving healing and regeneration of all bodily tissues and organs. The present invention relates to compositions and methods of managing, preventing, and treating scars. The invention also relates to prevention of deterioration, damage and malfunction of cells and tissues, and to promote, improve or exceed cellular function in order to promote, improve and exceed appearance, vitality and health. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products. Said components can also be synthesized. In other embodiments, the cells are differentiable cells preferably stem cells or eggs. In some embodiments, compositions are used in a method that comprises application of compositions to tissues, including skin and/or wounds after removal of tissue surface layers. In other embodiments, the invention relates to methods of dedifferentiation of cells and/or dedifferentiation followed by differentiation. In other embodiments, the invention relates to managing, preventing, and treating skin diseases.

公开(公告)号：EP2755664A2

公开(公告)日：2014-07-23

申请号：EP12830502.6

申请日：2012-03-06

申请人： Island Kinetics Inc.

发明人： PETER, David, Wayne ,  STANEK, John, Dillon ,  OROZCO, Cheria, L. ,  GUPTA, Shyam, K.

IPC分类号： A61K31/724 ,  C07H3/06 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q19/00 ,  A61P17/12 ,  A61P17/04 ,  A61P17/06 ,  A61P29/00

CPC分类号： A61K8/19 ,  A61K8/498 ,  A61K8/55 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7076 ,  A61K31/7135 ,  A61K31/715 ,  A61K45/06 ,  A61K48/00 ,  A61Q5/006 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/008 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention discloses certain chirally correct polyene cyclodextrin acetals and hemiacetals (formula I) that are effective in providing skin clarification, which is useful for the treatment of acne, and skin disfigurements and skin darkening resulting from acne; skin darkening from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial and DNA dysfunction; age spots; loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness, and combinations thereof;

公开(公告)号：EP2744907A1

公开(公告)日：2014-06-25

申请号：EP12738110.1

申请日：2012-07-20

申请人： Evonik Degussa GmbH

发明人： KÖHLER, Tim ,  SCHILD, Jennifer ,  MENTEL, Matthias ,  LERSCH, Peter ,  FARWICK, Mike ,  WEITEMEYER, Christian

IPC分类号： C12P13/00 ,  A61K8/44 ,  C12R1/89 ,  A61K8/97

CPC分类号： A61Q19/007 ,  A61K8/44 ,  A61K8/99 ,  A61K36/04 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/002 ,  A61Q19/004 ,  A61Q19/06 ,  A61Q19/08 ,  C12P13/005

摘要： The invention relates to a method for producing 4-aminobutyric acid, also know as gamma-aminobutyric acid, abbreviated to GABA, to a method for producing an extract containing 4-aminobutyric acid, to a method for producing a cosmetic formulation containing 4-aminobutyric acid, and to the use of cyanidium caldarium cells or cell constituents in cosmetic applications.

摘要翻译： 本发明涉及一种在短GABA中生产4-氨基丁酸的方法，涉及制备包含4-氨基丁酸的提取物的方法，用于制备 包含4-氨基丁酸的化妆品制剂，以及在化妆品应用中使用氰化镉细胞或细胞成分。

公开(公告)号：EP2538917A4

公开(公告)日：2014-05-07

申请号：EP11737358

申请日：2011-01-24

申请人： QUANTUM PHARMACEUTICALS LTD ,  ROYAL GOVERNMENT OF BHUTAN MINISTRY OF AGRICULTURE

发明人： DAHLGREN ATTI-LA ,  DAHLGREN JOHN ,  DORJI TASHI YANGZOME ,  DORJI SINGAY ,  GYELTSHEN SHERUB

IPC分类号： A61K8/97 ,  A61K36/185 ,  A61K36/898 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

CPC分类号： A61K8/97 ,  A61K36/185 ,  A61K36/898 ,  A61Q3/00 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention relates to an extract of Dionaea muscipula and a composition comprising such an extract for cosmetic treatment of the skin and skin appendages such as sebaceous glands, hair and nails especially skin changes due to accelerated or chronological aging e.g. wrinkles loss of firmness and elasticity, and increased pigmentation. It also regards the use of such an extract for the preparation of a composition for cosmetic treatment. The composition may comprise further substances active against skin changes due to accelerated or chronological aging e.g. wrinkles loss of firmness and elasticity, and increased pigmentation. Especially it may contain an extract from Cymbidium erythraeum. It may also comprise bases, cosmetic pigments, UV filters and/or UV scattering agents. The scope of the invention also covers a method for cosmetic treatment of the skin, especially skin changes due to accelerated or chronological aging e.g. wrinkles loss of firmness and elasticity, and increased pigmentation wherein a persons skin is treated with a composition comprising an extract from Dionaea muscipula. Such a composition may also contain an extract from Cymbidium erythraeum.

公开(公告)号：EP2086564B1

公开(公告)日：2014-04-02

申请号：EP07866447.1

申请日：2007-10-26

申请人： Société d'Extraction des Principes Actifs SA (Vincience)

发明人： DAL FARRA, Claude ,  DOMLOGE, Nouha ,  BOTTO, Jean-Marie

IPC分类号： A61K38/07 ,  A61K38/08 ,  A61K8/64 ,  A61Q17/04 ,  A61P17/16

CPC分类号： A61K38/08 ,  A61K8/64 ,  A61K38/07 ,  A61Q5/10 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04

公开(公告)号：EP1707189B1

公开(公告)日：2014-03-12

申请号：EP06013216.4

申请日：2000-09-20

申请人： Laboratoires Expanscience

发明人： Msika, Philippe ,  Piccirilli, Antoine

IPC分类号： A61K8/97 ,  A61K8/37 ,  A61K8/49 ,  A61K8/63 ,  A61K8/67 ,  A61K8/68 ,  A61K8/92 ,  A23L1/16 ,  A23L1/30 ,  A61Q19/10 ,  A61Q19/00 ,  A61K36/26 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K45/06 ,  A23K1/16

CPC分类号： A61Q19/10 ,  A23K20/158 ,  A23L33/11 ,  A23L33/115 ,  A61K8/375 ,  A61K8/4973 ,  A61K8/63 ,  A61K8/678 ,  A61K8/68 ,  A61K8/922 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/008 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/863 ,  A61K2300/00

公开(公告)号：EP2670766A1

公开(公告)日：2013-12-11

申请号：EP12708556.1

申请日：2012-01-30

申请人： ISP Investments Inc.

发明人： DAL FARRA, Claude ,  DOMLOGE, Nouha ,  BOTTO, Jean-Marie

IPC分类号： C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  A61K8/64

CPC分类号： A61K8/64 ,  A61K38/08 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08

摘要： This invention relates to peptide compounds of general formula (I) R1-(AA)n-X1-X2-X3-Asp-Leu-Lys-Lys-X4-X5-(AA)p-R2. Said peptide compounds have an action on the SCF/c-Kit signaling pathway and thus make it possible to protect skin pigment structures from external stresses. In addition, this invention relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically acceptable medium, and its use for attenuating age-related pigmentation defects and the effects of photoaging on the skin. The invention finally relates to various cosmetic treatment methods using said peptides according to the invention.