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    Molecular separation column and use thereof
    34.
    发明公开
    Molecular separation column and use thereof 失效
    MolekulareTrennungssäuleund deren Anwendung。

    公开(公告)号：EP0047617A2

    公开(公告)日：1982-03-17

    申请号：EP81303969.0

    申请日：1981-09-01

    申请人： AMF INCORPORATED

    发明人： Crowder III, Alvin L. ,  Hou, Kenneth C. ,  Dailey, Nils L. ,  Marinaccio, Paul J. ,  Fiore, Joseph V. ,  Ostreicher, Eugene A.

    IPC分类号： B01J20/28 ,  B01D15/08 ,  G01N30/02

    CPC分类号： B01J20/282 ,  B01D15/22 ,  B01J20/28004 ,  B01J20/28028 ,  B01J20/28033 ,  B01J20/28052 ,  B01J2220/54 ,  G01N30/56 ,  G01N2030/527

    摘要： A molecular separation column is provided for effecting differential distribution, between two phases, of the components of a sample flowing therethrough, said column containing a solid stationary phase which comprises a porous matrix of fiber having particulate immobilized therein, at least one of said fiber or particulate being effective for molecular separation, preferably the particulate, the matrix being substantially i homogeneous with respect to each component. When used in liquid-solid flow-through molecular separations, there is a reduced pressure drop and diffusional resistance so that the columns can be used for commercial scale liquid separations in addition to analytical separations.
    A method is also provided for effecting molecular separations by the use of such columns as well as providing for a solid phase for use in such columns.

    摘要翻译： 分子分离色谱柱，用于在两相之间实现流过其中的样品的组分的差分分布。 该柱包含基本均匀的固体固定相，其包含其中固定有颗粒的纤维的多孔基质，其中所述纤维或颗粒中的至少一种对分子分离是有效的。 该柱的特征在于降低的压降，增加的轴向分散，更均匀的峰形和更高的样品加载时的分离。

    ANALYTICAL METHOD AND APPARATUS
    40.
    发明公开
    ANALYTICAL METHOD AND APPARATUS 有权
    分析方法和设备

    公开(公告)号：EP1198710A1

    公开(公告)日：2002-04-24

    申请号：EP00950176.8

    申请日：2000-07-21

    申请人： PHARMACIA DIAGNOSTICS AB

    发明人： CARLSSON, Jan ,  LÖNNBERG, Maria

    IPC分类号： G01N33/53 ,  G01N33/561 ,  G01N27/447

    CPC分类号： G01N30/94 ,  G01N30/96 ,  G01N2030/388 ,  G01N2030/527 ,  Y10T436/156666

    摘要： The invention relates to a method for qualitative, semi-quantitative or quantitative determination of at least two analytes in an aqueous sample containing or suspected of containing the analytes, which method comprises the steps of: (i) providing a flow matrix comprising a separation zone extending in a first dimension thereof, and a detection zone extending in the first dimension in a spaced parallel relationship with the separation zone, the detection zone comprising an immobilized reagent capable of capturing the analytes through biospecific interaction therewith, (ii) applying the sample to the flow matrix at or upstream of the separation zone, (iii) initiating a first essentially aqueous fluid flow in the flow matrix along the separation zone in the first dimension to transport the analytes through the separation zone to be separated therein, (iv) interrupting the first fluid flow and initiating a second essentially aqueous fluid flow in a second dimension of the flow matrix substantially transverse to the first dimension towards the detection zone to transport the separated analytes to the detection zone to be captured therein by the immobilized reagent, and (vi) determining the analytes in the detection zone. The invention also relates to an apparatus for carrying out the method.

    摘要翻译： 本发明涉及用于定性，半定量或定量测定含有或怀疑含有分析物的含水样品中的至少两种分析物的方法，所述方法包括以下步骤：（i）提供包含分离区 在其第一维度上延伸;以及检测区域，其以与隔离区域隔开平行关系的方式在第一维度上延伸，检测区域包括能够通过与其分离的生物特异性相互作用捕获分析物的固定化试剂，（ii）将样品应用于 （iii）在所述流动基质中在所述第一维度上沿着所述分离区域引发第一基本上含水的流体流动，以将所述分析物运输通过所述分离区域以在其中分离，（iv）中断 第一流体流动并且在流动矩阵子的第二维度中引发第二基本上含水的流体流动 与所述第一维度垂直地朝向所述检测区域，以将所述分离的分析物传输至所述检测区域，以通过所述固定化试剂在其中捕获，以及（vi）确定所述检测区域中的所述分析物。 本发明还涉及用于执行该方法的设备。