公开(公告)号：EP2971132B1

公开(公告)日：2020-05-06

申请号：EP14764952.9

申请日：2014-03-17

申请人： Baylor Research Institute

发明人： GOEL, Ajay ,  HUR, Keun ,  TOIYAMA, Yuji ,  BOLAND, Richard C.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C40B40/06

公开(公告)号：EP3218511B1

公开(公告)日：2020-04-22

申请号：EP15793823.4

申请日：2015-11-11

申请人： Illumina Cambridge Limited

发明人： GUNDERSON, Kevin L. ,  BAI, Jingwei ,  KELLINGER, Matthew William ,  BEIERLE, John M. ,  BOUTELL, Jonathan Mark ,  RIGATTI, Roberto ,  ROGERT BACIGALUPO, Maria Candelaria ,  BOYANOV, Boyan ,  MAISINGER, Klaus

IPC分类号： C12Q1/6874 ,  B01J19/00 ,  C40B40/06 ,  C40B50/14

公开(公告)号：EP3597772A1

公开(公告)日：2020-01-22

申请号：EP19179386.8

申请日：2014-04-17

申请人： Agency for Science, Technology and Research

发明人： QUAKE, Stephen R. ,  BURKHOLDER, William F. ,  HONG, Lewis Z.

IPC分类号： C12Q1/68 ,  C40B40/06 ,  C40B50/06 ,  C12Q1/6869 ,  C12N15/10

摘要： The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of: assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules; amplifying the barcode-tagged molecules; fragmenting the amplified barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.

公开(公告)号：EP2734621B1

公开(公告)日：2019-09-04

申请号：EP12845790.0

申请日：2012-07-22

申请人： President and Fellows of Harvard College ,  Liu, David R. ,  Guilinger, John Paul ,  Pattanayak, Vikram

发明人： LIU, David, R. ,  GUILINGER, John, Paul ,  PATTANAYAK, Vikram

IPC分类号： C12N9/22 ,  C12N15/55 ,  C12Q1/44 ,  C12Q1/68 ,  C40B40/06 ,  A61K38/43

公开(公告)号：EP3519571A1

公开(公告)日：2019-08-07

申请号：EP17857297.0

申请日：2017-09-27

申请人： Aptitude Medical Systems, Inc.

发明人： WANG, Jinpeng ,  YANG, Qin ,  FERGUSON, Brian Scott ,  GONG, Qiang

IPC分类号： C12N15/10 ,  C12N15/115 ,  C12Q1/68 ,  C40B10/00 ,  C40B30/04 ,  C40B40/06

公开(公告)号：EP3204518B1

公开(公告)日：2019-07-10

申请号：EP15849044.1

申请日：2015-10-08

申请人： Invitae Corporation

发明人： OLIVARES, Eric

IPC分类号： C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6832 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6874 ,  C12Q1/6883 ,  C40B30/04 ,  C40B40/06 ,  C40B70/00 ,  C40B40/08

公开(公告)号：EP2781599B1

公开(公告)日：2019-05-08

申请号：EP12850348.9

申请日：2012-11-15

申请人： TagCyx Biotechnologies

发明人： HIRAO, Ichiro ,  HIRAO, Michiko ,  YAMASHIGE, Rie ,  YOKOYAMA, Shigeyuki

IPC分类号： C12N15/115 ,  A61K31/7115 ,  A61K48/00 ,  A61P9/00 ,  A61P43/00 ,  C07H21/02 ,  C07H21/04 ,  C12N9/00 ,  C12Q1/68 ,  C40B40/06 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

公开(公告)号：EP3443149A1

公开(公告)日：2019-02-20

申请号：EP17781661.8

申请日：2017-04-13

申请人： University Health Network (UHN)

发明人： PUGH, Trevor John ,  MULDER, David Thomas ,  MAHE, Etienne Raymond G. A.

IPC分类号： C40B40/06 ,  C12N15/10 ,  C12N15/12 ,  C12N15/13 ,  C12Q1/68 ,  C40B30/04

公开(公告)号：EP3411517A1

公开(公告)日：2018-12-12

申请号：EP17746659.6

申请日：2017-02-06

申请人： University Health Network

发明人： WANG, Jean ,  DICK, John ,  NG, Stanley ,  MINDEN, Mark ,  MITCHELL, Amanda ,  CHEN, Weihsu, Claire ,  ZANDSTRA, Peter ,  KENNEDY, James

IPC分类号： C40B40/06 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/08 ,  G01N33/48 ,  G06F19/10 ,  G06F19/20

CPC分类号： G01N33/57426 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B40/06 ,  C40B40/08 ,  G01N2800/52 ,  G06F19/10 ,  G06F19/20

摘要： There is described herein a method of prognosing or classifying a subject with acute myeloid leukemia (AML) comprising: (a) determining the expression level of at least 3 genes in a test sample from the subject selected from the group consisting of DNMT3B, ZBTB46, NYNRIN, ARHGAP22, LAPTM4B, MMRN1, DPYSL3, KIAAQ125. CDK6, CPXM1, SOCS2, SMIM24, EMP1, NGFRAP1, CD34, AKR1C3, GPR56; and (b) comparing expression of the at least 3 genes in the test sample with reference expression levels of the at least 3 genes from control samples from a cohort of patients; wherein a difference or similarity in the expression of the at least 3 genes in the test sample and the reference expression levels is used to prognose or classify the subject with AML into a low risk group or a high risk group for worse survival.

公开(公告)号：EP3408412A1

公开(公告)日：2018-12-05

申请号：EP17743495.8

申请日：2017-01-27

申请人： The University of Melbourne

发明人： JENKINS, Mark ,  BUCHANAN, Daniel ,  HOPPER, John L.

IPC分类号： C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C40B40/06

摘要： The present disclosure relates to methods and systems for assessing the risk of a human subject for developing colorectal cancer. These methods may be combined with the subjects clinical risk to improve risk analysis. Such methods may be used to assist decision making about appropriate colorectal cancer screening regimens.