公开(公告)号：EP0919537A3

公开(公告)日：2001-05-16

申请号：EP98121567.6

申请日：1998-11-18

申请人： Kao Corporation

发明人： Fukushima, Tetsuaki, Kao Corporation ,  Yoshida, Wataru, Kao Corporation ,  Abe, Hiroshi, Kao Corporation

IPC分类号： C07C209/84 ,  C07C213/04

CPC分类号： C07C213/04 ,  C07C217/50

摘要： The present invention provides a process for easily producing an alkylene oxide adduct to an aliphatic amine compound which has a fully excellent color, is not turbid, and does not deteriorate in color even through long-term storage. That is, the present invention provides a process for producing an alkylene oxide adduct to a primary or secondary amine compound having an aliphatic, saturated or unsaturated, hydrocarbon radical having 8 to 22 carbon atoms, having an excellent color, by reacting an alkyene oxide to the amine compound, characterized by comprising the step of adding a base or an aqueous solution thereof to the amine compound and then heating the mixture.

公开(公告)号：EP0654534B1

公开(公告)日：2000-03-01

申请号：EP94118213.1

申请日：1994-11-18

申请人： DAICEL CHEMICAL INDUSTRIES, LTD.

发明人： Furukawa, Kazuaki ,  Abe, Takayuki ,  Akamatsu, Hidekazu ,  Matsuyama, Akinobu ,  Ito, Michio ,  Yamasaki, Noritsugu ,  Miki, Katsuya ,  Ikura, Kiyoshi ,  Ishiguro, Takeshi

IPC分类号： C12P41/00 ,  C12P13/00 ,  C07C213/08 ,  C07C213/04 ,  C07C213/10

CPC分类号： C12P7/22 ,  C07C213/00 ,  C07C213/04 ,  C07C213/08 ,  C07C213/10 ,  C07C231/18 ,  C12P13/001 ,  C12P13/008 ,  C12P41/00 ,  C12P41/001 ,  C12P41/002 ,  Y10S435/822 ,  Y10S435/911 ,  C07C215/08

公开(公告)号：EP0976720A1

公开(公告)日：2000-02-02

申请号：EP98907258.2

申请日：1998-03-17

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： TANIGUCHI, Kiyoshi ,  SAKURAI, Minoru ,  HASHIMOTO, Norio ,  OKAMOTO, Takumi ,  TSUBAKI, Kazunori ,  SHIMIZU, Yasuyo ,  TAKASUGI, Hisashi

IPC分类号： C07C217/74 ,  C07C213/04 ,  A61K31/215

CPC分类号： C07C215/64 ,  C07C217/30 ,  C07C217/34 ,  C07C217/74 ,  C07C2602/10 ,  C07C2602/12 ,  Y02P20/55

摘要： This invention relates to new propanolamine derivatives presented by the following formula [I] :
wherein

R 1 is hydrogen or lower alkenyloxy,
R 2 is carboxy(lower)alkoxy or protected carboxy(lower)alkoxy,
R 3 is hydrogen or N-protective group,
n is an integer of 1 or 2,
and salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-pollakisuria activities, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

摘要翻译： 本发明涉及由下式表示的新的丙醇胺衍生物：其中R 1是氢或低级烯氧基，R 2是羧基（低级）烷氧基或被保护的羧基（低级）烷氧基，R 3， 是氢或N-保护基，n是1或2的整数，以及其具有肠选择性交感神经兴奋剂，抗溃疡性，抗胰腺炎，脂肪分解和抗花粉病活性的盐，其制备方法和 包含其的药物组合物。

公开(公告)号：EP0968173A1

公开(公告)日：2000-01-05

申请号：EP98903137.2

申请日：1998-02-05

申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian Roderick Michaelson

发明人： LANE, David, Redick,Nycomed Inc. ,  VASILEVSKIS, Janis,Nycomed, Inc.

IPC分类号： C07C213/04 ,  C07C231/12 ,  C07C231/14 ,  C07D303/36 ,  C07C233/65

CPC分类号： C07C231/12 ,  C07C213/04 ,  C07C231/14 ,  C07C233/65 ,  C07C237/30 ,  C07C237/42 ,  C07C233/18 ,  C07C233/22 ,  C07C237/46

摘要： The invention provides a process for the production of a 2,3-dihydroxypropylamino compound, said process comprising the reaction steps of: (i) obtaining an allylamino compound; (ii) epoxidizing said allylamino compound to yield an epoxypropylamino compound; and (iii) hydrolysing said epoxypropylamino compound to yield a 2,3-dihydroxypropylamino compound. This process may be used to produce simple 2,3-dihydroxypropylamino compounds such as APD or complex ones such as BAPD (an intermediate in the production of iohexol).

公开(公告)号：EP0924193A1

公开(公告)日：1999-06-23

申请号：EP99102714.5

申请日：1994-11-18

申请人： DAICEL CHEMICAL INDUSTRIES, LTD.

发明人： Furukawa, Kazuaki ,  Abe, Takayuki ,  Akamatsu, Hidekazu ,  Matsuyama, Akinobu ,  Ito, Michio ,  Yamasaki, Noritsugu ,  Miki, Katsuya ,  Ikura, Kiyoshi ,  Ishiguro, Takeshi

IPC分类号： C07C213/04 ,  C07C213/08 ,  C07C213/10

CPC分类号： C12P7/22 ,  C07C213/00 ,  C07C213/04 ,  C07C213/08 ,  C07C213/10 ,  C07C231/18 ,  C12P13/001 ,  C12P13/008 ,  C12P41/00 ,  C12P41/001 ,  C12P41/002 ,  Y10S435/822 ,  Y10S435/911 ,  C07C215/08

摘要： A process is provided for producing an (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative shown by the general formula (XI)
wherein R 1 - R 10 and Z represent a hydrogen atom etc., and R 11 represents a lower alkyl group, which comprises:

reacting an (R)-2-amino-1-phenylethanlol compound shown by the general formula (II)
and a compound shown by the general formula (VIII)
and reducing the reaction product of said reaction.

摘要翻译： 提供了一种制备通式（XI）所示的（R，R）-1-苯基-2-（2-苯基-1-烷基乙基）氨基乙醇衍生物的方法，其中R 1 -R 10和Z表示氢原子等，R 11表示低级烷基，其包括：使通式（II）所示的（R）-2-氨基-1-苯基十三醇化合物 和由通式（VIII）表示的化合物并还原所述反应的反应产物。 一个

公开(公告)号：EP0742243A3

公开(公告)日：1998-05-27

申请号：EP96106968

申请日：1996-05-03

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： KIHARA SHUTA ,  YONEHAMA SHINICHI ,  SEKI KICHIRO

IPC分类号： C07C213/04 ,  C07C217/50 ,  C08G59/18 ,  C08G59/50 ,  C08G65/26 ,  C08G65/32 ,  C08G65/329 ,  C08G73/02 ,  C08L71/02

CPC分类号： C08G73/02 ,  C08G59/184 ,  C08G65/2609 ,  C08G65/329 ,  C08L71/02 ,  C08L2666/22

摘要： Provided are a modified polyamine which comprises a reaction product between a polyamine and a chlorohydrin synthesized by the reaction of a polyoxyalkylene polyether with an epichlorohydrine and having a total chlorine content of 1,000 ppm or below, and an aqueous epoxy resin curing agent using the same.

摘要翻译： 本发明提供一种改性聚胺，其包括多胺和通过聚氧化烯聚醚的与表氯醇反应合成的氯代醇并且具有1000 ppm的或更低的总氯含量之间的反应产物，并在使用相同的wässrige环氧树脂固化剂。

公开(公告)号：EP0719247A4

公开(公告)日：1997-04-02

申请号：EP94929764

申请日：1994-09-09

申请人： SEPRACOR INC

发明人： GAO YUN ,  HONG YAPING ,  NIE XIAOYI ,  BAKALE ROGER PAUL ,  FEINBERG RICHARD ROBERT ,  ZEPP CHARLES MELVYN

IPC分类号： C07C213/04 ,  C07B61/00 ,  C07C213/08 ,  C07C215/44 ,  C07C233/23 ,  C07C233/74 ,  C07C213/02 ,  C07C213/10 ,  C07C231/02 ,  C07C231/18 ,  C07C231/24

CPC分类号： C07C213/08 ,  C07C215/44 ,  C07C233/23 ,  C07C233/74 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08

摘要： A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a trans-1-amino-2-hydroxycycloalkane to a cis-1-amino-2-hydroxycycloalkane. Methods for obtaining the trans-1-amino-2-hydroxycycloalkanes and their amides from alkenes are also disclosed. A preferred process converts indene to cis-1-amino-2-indanol.

公开(公告)号：EP0693474A4

公开(公告)日：1997-02-05

申请号：EP95907871

申请日：1995-02-10

申请人： TOYO BOSEKI

发明人： BAN MASAKAZU ,  SHINODA KIYOTAKA ,  TAKAHASHI MITSURU ,  DEGUCHI SHUHEI ,  TAGUCHI HIROAKI ,  KATSUSHIMA TAKEO

IPC分类号： A61K31/135 ,  A61K31/165 ,  A61K31/22 ,  A61P9/00 ,  C07C213/02 ,  C07C213/04 ,  C07C217/18 ,  C07C217/58 ,  C07C217/84 ,  C07C219/28 ,  C07C231/12 ,  C07C233/18 ,  C07C233/25 ,  C07C303/32 ,  C07C309/30

CPC分类号： C07C217/84 ,  C07C217/18 ,  C07C217/58 ,  C07C219/28 ,  C07C233/18 ,  C07C233/25

摘要： A novel benzylaminoethoxybenzene derivative represented by general formula (I), a salt thereof, or a solvate thereof; wherein R represents hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, aryl or benzyl; R represents hydrogen, lower alkyl, lower acyl, aryl or benzyl; R represents hydrogen, lower alkyl, lower alkoxyalkyl, lower dialkylaminoalkyl or lower acyl; and R represents hydrogen, halogen, lower alkoxy, amino, lower acylamino, hydroxy, lower acyloxy, lower acyl, carboxy or lower alkoxycarbonyl. An alpha-1 blocker prepared from this compound has a potent blocking effect and is reduced in the side effect of orthostatic hypotension.

公开(公告)号：EP0752412A1

公开(公告)日：1997-01-08

申请号：EP95110244.1

申请日：1995-06-30

申请人： BASF Aktiengesellschaft

发明人： Melder, Johann-Peter, Dr. ,  Ruider, Günther, Dr. ,  Witzel, Tom, Dr. ,  Ross, Karl-Heinz, Dr. ,  Boetiger, Günter, Dr.

IPC分类号： C07C215/00 ,  C07C213/04

CPC分类号： C07C213/04 ,  C07C215/08

摘要： Verfahren zur Herstellung von farbstabilem Dialkylaminoethanol der allgemeinen Formel I
in der R 1 und R 2 unabhängig voneinander C 1 - bis C 20 -Alkyl bedeuten, aus Dialkylamin der allgemeinen Formel II
in der R 1 und R 2 die obengenannten Bedeutungen haben, und Ethylenoxid, indem man die Umsetzung in Gegenwart von 2,5 bis 20 Gew.-% Wasser bei Temperaturen von 95 bis 170°C und die Abtrennung von Wasser und Hochsiedern durch Destillation bei einer Sumpftemperatur von 40 bis 90°C durchführt.

摘要翻译： 式HOCH2CH2NR1R2（I）的二烷基氨基乙醇的制备方法包括在2.5〜50％（重量）水的存在下，在95-170℃下使式HNR1R1（Ⅱ）的二烷基胺与环氧乙烷（III）反应，并通过蒸馏除去水和高沸点 在底部温度 40-90℃。R1，R2 = 1-20C烷基。

公开(公告)号：EP0632015A1

公开(公告)日：1995-01-04

申请号：EP93201901.1

申请日：1993-06-30

申请人： THE PROCTER & GAMBLE COMPANY

发明人： Hubesch, Bruno ,  Hardy, Frederick Edward ,  Simpson, Anthony J.

IPC分类号： C07C215/40 ,  C07C213/04 ,  C07C213/08

CPC分类号： C07C213/04 ,  C07C213/08

摘要： The present invention describes an alternative reaction path for the making of quaternary ammonium esters for fabric softening.
The process starts from a chloroepoxide which is reacted with ammonia and water to form a primary amino polyol. The process continues as reductive alkylation of the primary and then secondary amine with aldehydes to provide an intermediate tertiary amino polyol. The first part of the process is followed by the tradtional esterification and quaternisation steps known in the art for making quaternized ammonium fabric softening compounds.

摘要翻译： 本发明描述了可替换的反应路径的季铵酯的用于织物软化的决策。 该过程从开始chloroepoxide所有这一切都进行反应与氨和水反应形成伯氨基多元醇。 该过程继续用醛主然后仲胺作为还原性烷基化，以提供中间叔氨基多元醇。 该方法的第一部分是通过本领域中已知的用于制备季铵织物软化化合物的tradtional酯化和季铵化的步骤紧随其后。