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41.发明公开Methods for detecting cancers expressing vascular endothelial growth factor D 有权Verfahren zum Auffinden von Tumoren welche denvaskulärenendothelialen Wachstumsfaktor D exprimieren
公开(公告)号：EP1519193A2
公开(公告)日：2005-03-30
申请号：EP04027975.4
申请日：2001-03-02
发明人： Achen, Marc , Stacker, Steven
IPC分类号： G01N33/574 , A61K38/19 , G01N33/68
CPC分类号： G01N33/57492 , C07K16/22 , C07K2317/73 , G01N33/574 , G01N33/6872
摘要： A method for screening for neoplastic disease where detection of VEGF-D on or in cells such as tumour cells, blood vessel endothelial cells, lymph vessel endothelial cells, and/or cells with potential neoplastic growth indicates neoplastic disease; and also methods for screening tumours for metastatic or micro-metastatic risk where expression of VEGF-D by the tumour indicates metastatic risk.
摘要翻译： 用于筛选肿瘤疾病的方法，其中在细胞如肿瘤细胞，血管内皮细胞，淋巴管内皮细胞和/或具有潜在肿瘤生长的细胞中或细胞中检测VEGF-D指示肿瘤性疾病; 以及用于筛选肿瘤转移或微转移风险的方法，其中肿瘤中VEGF-D的表达指示转移性风险。
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公开(公告)号：EP0842273B1
公开(公告)日：2005-03-09
申请号：EP96925768.2
申请日：1996-08-01
发明人： ALITALO, Kari , JOUKOV, Vladimir
CPC分类号： C07K14/71 , A61K38/00 , A61K2039/505 , C07K14/475 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2319/00 , C07K2319/30
摘要： Provided are polypeptide ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligands, pharmaceutical compositions and diagnostic reagents comprising the ligands, and methods of making ans using the ligands.
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公开(公告)号：EP0653940B1
公开(公告)日：2004-12-29
申请号：EP93918139.2
申请日：1993-06-29
发明人： GOODEARL, Andrew 45 Blacketts Wood Drive , STROOBANT, Paul , MINGHETTI, Luisa , WATERFIELD, Michael Chantemerlc , MARCHIONI, Mark , CHEN, Maio, Su , HILES, Ian
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4756 , C07K14/82 , C07K16/22 , C12N2799/026
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公开(公告)号：EP1487857A1
公开(公告)日：2004-12-22
申请号：EP03713942.5
申请日：2003-03-07
发明人： ALITALO, Kari,Molecular/Cancer Biology Laboratory , MAKINEN, Taija,Dept. of Molecule Neurobiology , PETROVA, Tatiana,Molecular/Cancer Biology Lab. , SAHARINEN, Pipsa,Molecular/Cancer Biology Lab. , SAHARINEN, Juha,Molecular/Cancer Biology Lab.
CPC分类号： C07K16/22 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , G01N33/574 , G01N33/5748 , G01N2800/52
摘要： The invention provides polynucleotides and genes that are differentially expressed in lymphatic versus blood vascular endothelial cells. These genes are useful for treating diseases involving lymphatic vessels, such as lymphedema, various inflammatory diseases, and cancer metastasis via the lymphatic system.
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45.发明授权ISOLATED NONAPEPTIDE DERIVED FROM MAGE-3 GENE AND PRESENTED BY HLA-A1, AND USES THEREOF 失效从MAGE-3基因的和HLA-A1-提出，隔离九肽及其应用
公开(公告)号：EP0658113B1
公开(公告)日：2004-10-20
申请号：EP93920419.4
申请日：1993-08-30
发明人： BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , DE PLAEN, Etienne , LURQUIN, Christophe , TRAVERSARI, Catia
IPC分类号： C07K14/705 , C07K16/30 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
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46.发明授权
公开(公告)号：EP1126870B1
公开(公告)日：2004-09-08
申请号：EP99956559.1
申请日：1999-10-26
发明人： YLA-HERTTUALA, Seppo University of Kuopio , ALITALO, Kari Uni. of Helsinki, Haartman Inst. , HILTUNEN, Mikko, O. University of Kuopio , JELTSCH, Markku M Uni. of Helsinki, Haartman Inst , ACHEN, Marc, G. Ludwig Institute for Cancer Res.
CPC分类号： A61K38/1866 , A61F2/82 , A61K48/00
摘要： The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth Factor D (VEGF-D) genes or proteins.
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公开(公告)号：EP1425580A2
公开(公告)日：2004-06-09
申请号：EP02756453.3
申请日：2002-07-12
发明人： ALITALO, KariMolecular/Cancer Biology Laboratory , MAKINEN, TaijaMolecular/Cancer Biology Laboratory
CPC分类号： C12N5/069 , C12N2501/165 , G01N33/56966 , G01N2333/71
摘要： The present invention is directed to methods and compositions for isolating lymphatic endothelial cells from a mixed population of cells. More particularly, the inventors have found that certain antibodies that recognize the extracellular domain of VEGFR-3 can be used to specifically isolated lymphatic endothelial cells substantially free of other contaminating non-lymphatic endothelial cells. Methods and compositions for producing such cells and using such cells are described.
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48.发明授权ISOLATED PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-C-CLONE 10 AND USES THEREOF 失效与MHCMULEKÜLHLA-C克隆10复杂的形式和用途分离的肽
公开(公告)号：EP0711173B1
公开(公告)日：2004-05-19
申请号：EP94920715.3
申请日：1994-06-10
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
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公开(公告)号：EP0850319B1
公开(公告)日：2004-03-24
申请号：EP96930710.7
申请日：1996-09-04
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , C12N5/00
CPC分类号： C07K14/523 , A61K38/00 , C07K14/5412
摘要： The invention is based upon the newly recognized ability of beta chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known beta chemokines I-309 and TCA-3 are examples of the beta chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of beta chemokine inhibitors or antagonists to provoke apoptosis.
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公开(公告)号：EP1395276A1
公开(公告)日：2004-03-10
申请号：EP02731790.8
申请日：2002-05-14
发明人： GAIRIN, Jean E.,Institut de Pharmacologie du CNRS , BLACHET, Jean-Sebastien,CNRS , DUFAU, I.,Institut de Pharmacologie du CNRS , NGUYEN, C.,Institut de Pharmacologie du CNRS , MONSARRAT, B.,Institut de Pharmacologie du CNRS , VALMORI, Danila , ROMERO, Pedro , CEROTTINI, Jean-Charles
CPC分类号： C07K14/4748 , A61K38/1709
摘要： This invention relates to modified peptides that bind to an HLA molecule, particularly an HLA-A*0201 molecule wherein the modified peptides have a binding efficiency and immunogenicity similar to that of the parental non-modified peptide. This invention relates particularly to modified analogs of the tumor associated antigen Melan-A26-35A27L that have at least, one or more modified amino acid at positions lor 2 or (b ) one or more modified amino acid at positions 8, 9 or 10. The isolated modified peptides have a half-life in human serum of at least about 12 hours. Also disclosed are methods of using 10 such modified peptides. The invention also relates to methods for using the modified peptides of this invention.
摘要翻译： 本发明涉及与HLA分子结合的修饰的肽，特别是HLA-A * 0201分子，其中修饰的肽具有与亲本非修饰肽类似的结合效率和免疫原性。 本发明特别涉及到肿瘤相关抗原黑素-A A26-35A27L具有至少一个或多个修饰的氨基酸的位置处或2或（b）一种或多种修饰的氨基酸在位置8,9或10的修饰的类似物。 分离的修饰肽在人血清中具有至少约12小时的半衰期。 还公开了使用10种这样的修饰肽的方法。 本发明还涉及使用本发明的修饰肽的方法。
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