公开(公告)号：EP2252895A2

公开(公告)日：2010-11-24

申请号：EP09713413.4

申请日：2009-02-23

申请人： VANDERBILT UNIVERSITY ,  University of Miami

发明人： CANTER, Jeffrey, A. ,  PERICAK-VANCE, Margaret, A. ,  SPENCER, Kylee, M. ,  HAINES, Johnathan

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2800/164

摘要： The invention generally concerns methods and compositions for screening individuals for susceptibility to age-related macular degeneration (AMD). In particular, association with the various markers including complement factor H, LOC387717/ARMS2, C2/CFB, C3 and VEGF, indicates that a subject is at risk of AMD.

公开(公告)号：EP2231231A2

公开(公告)日：2010-09-29

申请号：EP08859889.1

申请日：2008-12-10

申请人： Patton Medical Devices, LP

发明人： AMBRUZS, William ,  BURNS, Lauren ,  CHRISTIAN, Joseph ,  HIGHLEY, Brian ,  ADAMS, Jason ,  HOUSSIERE, Charles ,  JACKSON, Randy

IPC分类号： A61M5/158 ,  A61M5/162

CPC分类号： A61M5/158 ,  A61M2005/1581 ,  A61M2005/1585

摘要： Insertion devices for installing insertion sets to a user, insertion needles, methods for loading insertion devices with insertion sets, methods for installing insertion sets, methods for instructing others how to load and/or install insertion sets, and certain aspects of insertion sets, including insertion needle hubs.

公开(公告)号：EP1928762B1

公开(公告)日：2010-06-02

申请号：EP05799840.3

申请日：2005-11-09

申请人： Sin Sheng Kuang (M) SDN BHD

发明人： PHEE, Boon, Eow ,  PHEE, Boon, Chee

IPC分类号： B65D81/34 ,  B65D33/01 ,  B65D51/16

CPC分类号： B65D81/3461 ,  B65D33/2508 ,  B65D33/2583 ,  B65D75/008 ,  B65D2205/00

公开(公告)号：EP1691833B1

公开(公告)日：2010-03-03

申请号：EP04803302.1

申请日：2004-11-26

申请人： Micromet AG

发明人： Hofmeister, Robert ,  Prang, Nadja ,  Wolf, Andreas ,  Hanakam, Frank ,  Urbig, Thomas ,  Itin, Christian ,  Baeuerle, Patrick

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/30 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/56

公开(公告)号：EP1444348B1

公开(公告)日：2010-01-27

申请号：EP02776280.6

申请日：2002-10-24

申请人： Monsanto Technology LLC

发明人： NORRIS, Susan, R. ,  LINCOLN, Kim ,  STEIN, Joshua, C. ,  VALENTIN, Henry, E. ,  VAN EENENNAAM, Alison

IPC分类号： C12N15/29 ,  C12N15/82 ,  A01H5/00 ,  A01H5/10

CPC分类号： C12N15/8243 ,  C12N9/1007

公开(公告)号：EP2136633A1

公开(公告)日：2009-12-30

申请号：EP08732358.0

申请日：2008-03-17

申请人： Jennerex, Inc.

发明人： KIRN, David

IPC分类号： A01N43/04 ,  A01N63/00 ,  A61K31/70 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K35/768 ,  A61K38/193 ,  C12N2710/24132 ,  C12N2710/24143 ,  C12N2710/24171

摘要： Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations. Further aspects of the invention include methods for inducing oncolysis or collapse of tumor vasculature in a subject having a tumor comprising administering to a subject administered at least 1×108 viral particles of a TK-deficient, GM-CSF-expressing, replication-competent vaccinia virus vector sufficient to induce oncolysis of cells in the tumor.

公开(公告)号：EP2135952A2

公开(公告)日：2009-12-23

申请号：EP09009758.5

申请日：2004-09-14

申请人： RESEARCH DEVELOPMENT FOUNDATION

发明人： Vale, Wylie ,  Gray, Peter C. ,  Harrison, Craig Adam

IPC分类号： C12N15/12 ,  C07K14/71 ,  A61K38/17

CPC分类号： C07K16/22 ,  C07K14/47 ,  C07K14/475 ,  C07K14/71 ,  C07K14/82

摘要： Cripto, a developmental oncoprotein, antagonizes activin and TGF-β signaling by forming a complex with activin and TGF-β and their type II receptors. This complex precludes the formation of a functional activin/TGF-β•type II•type I complex, thereby blocking the signaling of activin and TGF-β. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-β complex may enhance antiproliferative effects of activin and TGF-β.

摘要翻译： Cripto是发育中的癌蛋白，通过与激活素和TGF-β2及其II型受体形成复合物拮抗激活素和TGF-β信号传导。 该复合物排除形成功能性激活素/ TGF-βII型复合物，从而阻断激活素和TGF-β的信号传导。 Cripto通常能够阻断抗增殖Smad2 / 3信号并提供具有多种治疗意义的致癌作用的新机制。 抑制Cripto和激活素/ TGF-β复合物的形成可增强激活素和TGF-β2的抗增殖作用。

公开(公告)号：EP2131856A2

公开(公告)日：2009-12-16

申请号：EP08731723.6

申请日：2008-03-07

申请人： UTI Limited Partnership

发明人： SANTAMARIA, Pere ,  MOORE, Anna

IPC分类号： A61K39/00 ,  A61K39/385 ,  A61P37/00 ,  A61P37/06

CPC分类号： A61K39/0008 ,  A61K9/5094 ,  A61K39/385 ,  A61K47/6923 ,  A61K47/6929 ,  A61K2039/55555 ,  A61K2039/572 ,  A61K2039/60 ,  A61K2039/605 ,  A61K2039/6093 ,  A61K2039/627 ,  G01N33/54313 ,  G01N33/564 ,  G01N33/56972 ,  G01N2333/70539 ,  G01N2800/042

摘要： The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.

公开(公告)号：EP2121765A2

公开(公告)日：2009-11-25

申请号：EP07870193.5

申请日：2007-12-21

申请人： Biomérieux

发明人： BEISSINGER, Martina ,  MILLER, Stefan ,  PHILIPP, Anja ,  SCHÜTZ, Michael

IPC分类号： C07K19/00 ,  C12N15/62 ,  C12N9/88 ,  C07K14/315 ,  G01N33/569

CPC分类号： C12N9/88 ,  C07K14/005 ,  C07K14/195 ,  C07K14/32 ,  C07K2319/035 ,  C07K2319/70 ,  C12N2795/10022 ,  G01N33/56911 ,  G01N2469/10

摘要： The invention relates to polypeptides comprising an enzymatically inactive, cell wall-forming domain of an endolysin or another cell wall-lytic enzyme as well as a sequence according to SEQ ID NO: 1 or derivatives thereof, said polypeptide comprising no other endolysin domains in addition to the cell wall-forming domain. Also disclosed are means for producing said polypeptides. The invention further relates to methods for binding, concentrating, removing from a sample, trapping, and/or detecting bacteria, particularly gram-positive bacteria.

公开(公告)号：EP2117596A2

公开(公告)日：2009-11-18

申请号：EP07857604.8

申请日：2007-12-14

申请人： TIMA Foundation

发明人： MATUSCHKA-GREIFFENCLAU, Markus, Graf von ,  INUFUSA, Haruhiko

IPC分类号： A61K45/06 ,  A61P3/10 ,  A23L1/303 ,  A23L1/305

CPC分类号： A61K31/198 ,  A23L33/15 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/194 ,  A61K31/375 ,  A61K31/455 ,  A61K31/525 ,  A61K45/06 ,  A23V2200/328 ,  A23V2250/0618 ,  A23V2250/0616 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/036 ,  A23V2250/314 ,  A23V2250/708 ,  A23V2250/062

摘要： The present invention relates to compositions comprising glutamic acid and/or glutamine, cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, niacin, optionally vitamin C, and/or prodrugs of these substances and/or salts of these substances. The compositions can be used as food supplement and/or medicament for prophylaxis or treatment of several disease conditions, in particular of hyperglycemia and related diseases or disorders. Consequently, the present invention is also directed to pharmaceutical compositions for the use in human and veterinary medicine as well as method of treatments of said diseases.