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    THROMBUS-TARGETED COMPLEXES OF PLASMINOGEN ACTIVATOR AND FIBRIN FRAGMENTS
    44.
    发明公开
    THROMBUS-TARGETED COMPLEXES OF PLASMINOGEN ACTIVATOR AND FIBRIN FRAGMENTS 失效
    血栓的前瞻性COMPLEX FROM纤溶酶原激活剂和纤维蛋白组成。

    公开(公告)号：EP0473689A1

    公开(公告)日：1992-03-11

    申请号：EP90908772.0

    申请日：1990-05-21

    申请人： Temple University of the Commonwealth System of Higher Education

    发明人： BUDZYNSKI, Andrei, Z. ,  KNIGHT, Linda, C. ,  HASAN, Ahmed, Ak.

    IPC分类号： A61K38 ,  C07K1 ,  C07K14 ,  C07K19 ,  C12N9

    CPC分类号： C12N9/6456 ,  A61K38/49 ,  C07K14/75

    摘要： Des agents hybrides thrombolytiques sont obtenus sous la forme de complexes covalents ou non covalents de fragments de fibrine et de molécules d'un activateur de plasminogène. Des fragments de dégradation de plasmine naturelle de fibrine ou des fragments de fibrine non naturels sont liés de manière covalente ou non covalente à des activateurs de plasminogène tels que tPA, scu-A, urokinase, streptokinase, et autres. Des fragments de fibrine naturels utiles pouvant être utilisés pour former des complexes avec des activateurs de plasminogène comprennent les fragments E1, E2, E3, D et DD, et le complexe (DD)E. Le composant de fragment de fibrine cible l'agent hybride sur les thrombus vasculaires immobilisant la molécule de plasminogène sur la surface de la fibrine du thrombus. Une fois localisé sur la surface d'un thrombus, le composant de l'activateur de plasminogène de l'agent hybride active uniquement le plasminogène lié à la surface du caillot transporté par le véhicule de fragment de fibrine, sans activation systémique significative de plasminogène.

    Method, test strain and test kit for the laboratory diagnosis of neisseria gonorrhoeae
    46.
    发明公开
    Method, test strain and test kit for the laboratory diagnosis of neisseria gonorrhoeae 失效
    方法，实验菌株和检测试剂盒为淋病奈瑟氏球菌的实验室诊断。

    公开(公告)号：EP0081078A1

    公开(公告)日：1983-06-15

    申请号：EP82109984.3

    申请日：1982-10-28

    申请人： Temple University of the Commonwealth System of Higher Education

    发明人： Zubrzycki, Leonard Joseph

    IPC分类号： C12Q1/04 ,  C12Q1/12 ,  C12N1/20

    CPC分类号： C12R1/36 ,  C12N1/20 ,  C12Q1/04 ,  C12Q1/12 ,  G01N2333/22 ,  Y10S435/871

    摘要： A strain of Neisserie gonorrhoeae ATCC 31953 is described which has characteristically poor growth on chocolate agar at a temperature range of about 30°C to about 37°C In a CO 2 stmosphere suitable for growth of N. gonorrhoeae. This strain is resistant to nalidixic acid at the 5-10 mog/ml level and resistant to streptomycin at the 1000 meg/ml level or greater. The strain is suitable for a method for the laboratory diagnosis of gonorrhea, comprising the steps of (1) preparing a test strain of the microorganism Neisseria gonorrhoeae which is competent for transformation, (2) extracting N. gonorrhoeae DNA from a patient's apecimen material or colonies suspected of being N. gonor- rhoeae whether in pure or mixed culture by treatment with a base which lyses N. gonorrhoeae, (3) adusting the pH of the extract of step (2) to a pH that is not toxic to the test strain, (4) applying the pH adjusted extract to the test strain before or after putting it on or into a biological medium suitable for growth of N. gonorrhoese, (5) maintaining the treated test strain at optimum N. gonorrhoeae growth conditions which are Inhibitory for the test strain and (6) observing for detectable growth of the treated test strain. The observance of growth Indicates detection of N. gonorrhoeae DNA. Also described is a test kit for performing the method.