摘要:
Novel acetamide compounds of the formula, [wherein R₁ and R₂, each independently represents a hydrogen atom, a C₁ to C₆ straight- or branched-chain alkyl or alkenyl group, C₃ to C₆ cycloalkyl or cycloalkenyl group or an C₆ to C₁₀ aromatic group or R₁ and R₂ join with each other in combination with the adjacent N and carbon atoms or further with at least one of nitrogen, oxygen and sulfur atoms to represent a 5- or 6-membered heterocyclic ring group: R₃ represents a C₁-C₆ straight- or branched-chain alkyl or alkenyl group, C₃ to C₆ cycloalkyl or cycloalkenyl group, a halogen atom, a C₁-C₆ straight or branched-chain alkoxyl group, or a C₃-C₆ cycloalkoxy or cycloalkenoxy group and n is 0 to 4] and their pharmaceutically acceptable salts are useful in the treatment of ulcers in mammals.
摘要:
Novel quaternary ammonium compounds of the formula, [wherein R₁ and R₂, each independently represents a hydrogen atom, a C₁ to C₈ alkyl or alkenyl group, C₃ to C₈ cycloalkyl or cycloalkenyl, aralkyl or aryl group; or R₁ and R₂ join with each other in combination with the adjacent N and carbon atoms or further with at least one of nitrogen, oxygen and sulfur atoms to represent a 3- to 8-membered heterocyclic ring group: R₃, R₄ and R₅, each independently represents a C₁ to C₈ alkyl or alkenyl group, C₃ to C₈ cycloalkyl or cycloalkenyl, aralkyl or aryl group; or either two of R₃, R₄ and R₅ combine with each other in combination with the adjacent N and carbon atoms or further with at least one of nitrogen, oxygen and sulfur atoms to represent a 3- or 8-membered heterocyclic ring group, with the remaining being the same as defined above; or R₃, R₄ and R₅ combine with one another in combination with the adjacent N to represent a nitrogen-containing bicyclo ring or nitrogen-containing aromatic ring group: n is an integer of 1 to 8; and X⁻ represents an anion] and their pharmaceutically acceptable salts are useful in the treatment of ulcers in mammals.
摘要:
Anovel drug for prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis, or other hepatopathies caused by drugs, poisons, radiation, etc., which contains carnosine as effective ingredient and which is administered orally to exhibit significant effects.
摘要:
An oral antihepatopathic composition comprises protoporphyrin IX-Zn(II) complex, which complex suppresses the elevation of GPT and GOT as well as the increase of liver weight in a patient suffering from hepatic disorder.
摘要:
A novel crystalline L-carnosine zinc complex is produced by reacting L-carnosine, a zinc salt and an alkali metal compound in an anhydrous or hydrous polar organic solvent. The crystalline L-carnosine zinc complex substantially corresponds to the formula C₉H₁₂N₄O₃Zn and has physical properties clearly different from the known amorphous L-carnosine zinc complex. As compared with the amorphous complex, the crystalline complex is very low in impurity, stable to heat and moisture, and easy to filtrate, and has higher antiulcer activity.
摘要:
An oral antihepatopathic composition comprises protoporphyrin IX-Zn(II) complex, which complex suppresses the elevation of GPT and GOT as well as the increase of liver weight in a patient suffering from hepatic disorder.
摘要:
Novel 1,5-benzothiazepine derivatives having the formula: wherein R,, R 2 and R 3 each denotes hydrogen, a halogen, a lower alkyl group, a lower alkoxy group or a hydroxy group; R 4 denotes a lower alkyl group, an allyl group, a lower alkoxyalkyl group, a lower alkyl group substituted with a hydroxy group or a halogen, a lower alkylaminoalkyl group or a morpholino lower alkyl group; X denotes a halogen or hydrogen, are produced from corresponding 1,4-benzothiazine by a ring expansion reaction with trimethylhalosilane, hydrogen peroxide and water. The derivatives have analgesic, antipyretic and antiarrhythmic activities.
摘要:
Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid. The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1):
by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.