PROCESS FOR THE PREPARATION OF 2,6-DIHALO-PARA-TRIFLUOROMETHYLANILINE
    42.
    发明公开
    PROCESS FOR THE PREPARATION OF 2,6-DIHALO-PARA-TRIFLUOROMETHYLANILINE 有权
    制备2,6-二氢对 - 三氟甲基胺的方法

    公开(公告)号:EP1558560A2

    公开(公告)日:2005-08-03

    申请号:EP03780071.1

    申请日:2003-10-24

    CPC classification number: C07C209/74 C07C211/52

    Abstract: Process for the preparation of a compound of general formula (I): in which X represents a halogen atom, by reaction of para-trifluoromethylaniline of formula (II): with a dihalogen x2, the two compounds being introduced simultaneously into a polar aprotic solvent in a dihalogen/compound (II) molar ratio ranging from 1.9 to 2.5 and at a temperature ranging from 100 to 300° C.

    Abstract translation: 通式(II)的对三氟甲基苯胺与二卤素x2反应制备通式(I)化合物的方法:其中X代表卤素原子,两种化合物同时引入极性非质子溶剂 在二卤素/化合物(II)的摩尔比范围为1.9至2.5并且温度范围为100至300℃

    MANUFACTURING METHOD FOR 4-NITROSOANILINE FROM UREA AND NITROBENZENE
    44.
    发明公开
    MANUFACTURING METHOD FOR 4-NITROSOANILINE FROM UREA AND NITROBENZENE 有权
    用于生产四亚硝基苯尿素和硝基苯

    公开(公告)号:EP1230208A4

    公开(公告)日:2004-09-29

    申请号:EP00911452

    申请日:2000-03-15

    CPC classification number: C07C209/00 C07C211/52

    Abstract: Disclosed herein is a method for preparing 4-nitrosoaniline, comprising reacting urea and nitrobenzene in a polar organic solvent in the presence of a base at a temperature of room temperature to 150 °C. The method uses a relatively cheap urea and nitrobenzene as the raw materials, and also a relatively cheap base, thereby decreasing the manufacturing cost. Urea used as an amine donor is excellent in a reactivity to nitrobenzene, and a reaction intermediate is unstable as compared with 4-(4-nitrophenyl)benzamide to easily decompose into 4-nitroaniline and 4-nitrosoaniline. This allows a reaction time and a process time to be shortened. Moreover, the method is advantageous in that waste hazardous to the environment is not produced as a byproduct.

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