公开(公告)号：EP0157022B1

公开(公告)日：1988-04-27

申请号：EP84201856.6

申请日：1984-12-13

申请人： RÜTGERSWERKE AKTIENGESELLSCHAFT

发明人： Orth, Winfried, Dr. ,  Pastorek, Emmerich, Dr. ,  Fickert, Werner, Dr.

IPC分类号： C07D311/92

CPC分类号： C07C51/363 ,  C07C63/72

公开(公告)号：EP0138156A3

公开(公告)日：1987-02-04

申请号：EP84111838

申请日：1984-10-03

申请人： TOYO SODA MANUFACTURING CO., LTD.

发明人： Oyama, Koyotaka ,  Haradam, Tuneo

IPC分类号： C07C121/66 ,  C07C57/58 ,  C07C67/343 ,  C07C69/65

CPC分类号： C07C255/00 ,  C07C51/347 ,  C07C51/363 ,  C07C57/58

摘要： A process for producing a halogen-containing ethylbenzene derivative represented by the general formula:
where X is a halogen atom, and Y is a nitrile group, a carboxyl group, a lower alkoxycarbonyl group or an amidocarbonyl group, which comprises reacting a vinyl compound represented by the general formula:
where Y is as defined above, with a benzenediazonium salt and halogen ions in a solvent mixture comprising a lower alcohol and/or an ether, and water, under an acidic condition with a mineral acid, in the presence of a monovalent copper compound as a catalyst.

公开(公告)号：EP0131174A1

公开(公告)日：1985-01-16

申请号：EP84106915.6

申请日：1984-06-16

申请人： BEECHAM GROUP PLC

发明人： Burton, George ,  Best, Desmond John

IPC分类号： C07D499/68 ,  C07D501/20 ,  C07D241/08 ,  C07C101/72 ,  C07C125/065 ,  A61K31/43 ,  A61K31/545

CPC分类号： C07D499/00 ,  C07C51/363 ,  C07C59/56 ,  C07D241/08

摘要： A compound having the partial structure (I)
wherein R' and R 2 may be the same or different and each is hydrogen or a group -COR 5 or -CO-OR 5 wherein R 5 represents an optionally substituted hydrocarbon group; R 3 is halogen and R 4 is hydrogen, methoxy, hydroxymethyl or formamido.
These compounds are suitably bicyclic β-lactam antibiotics

公开(公告)号：EP0111997A2

公开(公告)日：1984-06-27

申请号：EP83306078.3

申请日：1983-10-07

申请人： Takeda Chemical Industries, Ltd.

发明人： Terao, Shinji ,  Nishikawa, Kohei

IPC分类号： C07D213/55 ,  C07D409/04 ,  C07D213/57 ,  A61K31/44 ,  A61K31/38

CPC分类号： C07D213/30 ,  C07C51/363 ,  C07D201/08 ,  C07D213/26 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D213/57 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07F9/5407 ,  C07C53/19 ,  C07C57/58

摘要： Novel compound of the formula:
[wherein R 1 is a pyridyl group; R 2 is a phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl group which may have as a substituent a lower alkoxy, a lower alkyl, a halogen, trifluoromethyl, a lower alkenyl or methylenedioxy; R 3 is hydrogen, benzyl or a lower alkyl; one of R 4 and R 5 is hydrogen or a lower alkyl, and the other is an aryloxy, or lower aliphatic hydrocarbon, an alicyclic hydrocarbon having not more than 6 carbon atoms or an aromatic group which may have a substituent, or a group represented by the formula, -S(O) m -R 6 (in which R 6 is phenyl or a lower alkyl group; m is an integer of 0 to 2), or R 4 and R 5 each combine with the other to represent an alkylene group; n is an integer of 2 to 6], or a pharmaceutically acceptable salt thereof, has a selective inhibitory action on bio-synthesis of thromboxane A 2 (TXA 2 ) and an effect of enhancing the production of prostaglandin I 2 (PGI 2 ), and can be used for mammals in the prevention and treatment of arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vaso- spasms in cardiac, cerebral and peripheral circulatory systems (e.g. cardian infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

公开(公告)号：EP0089650A1

公开(公告)日：1983-09-28

申请号：EP83102721.4

申请日：1983-03-18

申请人： SANKYO COMPANY LIMITED

发明人： Takeshiba, Hideo, c/o Agricultural Chem.Res.Lab. ,  Kinoto, Takao, c/o Agricultural Chem. Res. Lab. ,  Jojima, Teruomi, c/o Agricultural Chem.Res. Lab.

IPC分类号： C07D237/14 ,  C07D237/04 ,  C07D401/12 ,  A01N43/58

CPC分类号： C07D401/12 ,  A01N43/58 ,  C07C45/46 ,  C07C45/63 ,  C07C51/347 ,  C07C51/363 ,  C07C59/88 ,  C07C323/00 ,  C07D237/04 ,  C07D237/14 ,  C07C49/807 ,  C07C49/76

摘要： Compounds of formula (I):
[wherein R' and R 3 represent hydrogen or halogen atoms, R 2 represents a hydrogen or halogen atom or a lower alkyl or alkoxy group (provided R', R 2 and R 3 are not simultaneously hydrogen), ...... represents a single or double carbon-carbon bond and, where it is a single bond, R 4 represents a group of formula -SR 5 (wherein R 5 represents an optionally substituted alkyl, phenyl, aralkyl or pyridyl group or a lower alkenyl group) and, where it is a double bond, R 4 represents hydrogen] can be prepared by reacting a compound of formula (II):
with a compound of formula R 6 H [where R 6 represents a group -SR 5 , a group -SR 7 (where R 7 represents a group of formula
and Y represents oxygen or sulphur, R 8 and R 9 represent lower alkoxy groups and R 10 represents a lower alkoxy, lower alkyl or phenyl group), a methoxy group or a halogen atom) to give a compound of formula (IV):
or, where R 6 represents a methoxy group, a methyl ester thereof; reacting this compound with hydrazine to give a compound of formula (V):
or (VI):
and if necessary, treating the compound of formula (V) with an acid or a base to produce the compound of formula (VI). All of the compounds of formula (I) are valuable antifungal agents and compounds of formula (V) where R 6 represents a group of formula -SR 5 are novel compounds.

公开(公告)号：EP0016867B1

公开(公告)日：1983-06-22

申请号：EP79105314.3

申请日：1979-12-21

申请人： F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

发明人： Guthrie, Robert William ,  Kierstead, Richard Wightman ,  Mennona, Francis A. ,  Sullivan, Ann Clare

IPC分类号： C07C59/295 ,  C07D305/12 ,  C07C51/09 ,  A61K31/00 ,  C07B19/00

CPC分类号： C07D305/12 ,  C07C51/09 ,  C07C51/363 ,  C07C59/295 ,  C07D303/48

公开(公告)号：EP0021121B1

公开(公告)日：1983-05-11

申请号：EP80103032.1

申请日：1980-05-30

申请人： THE WELLCOME FOUNDATION LIMITED

发明人： Baxter, Martin George ,  Elphick, Albert Reginald ,  Miller, Alistair Ainslie ,  Sawyer, David Alan

IPC分类号： C07D253/06 ,  A61K31/53

CPC分类号： C07D253/075 ,  C07C51/15 ,  C07C51/363 ,  C07C255/00 ,  C07C281/18 ,  C07C63/70

公开(公告)号：EP0069339A2

公开(公告)日：1983-01-12

申请号：EP82105835.1

申请日：1982-06-30

申请人： KURARAY CO., LTD.

发明人： Yoshimura, Noriaki ,  Tamura, Masuhiko

IPC分类号： C07C45/51 ,  C07C47/21 ,  C07C45/62 ,  C07C47/02 ,  C07C29/17 ,  C07C85/08 ,  C07C101/04 ,  C07C121/40

CPC分类号： C07C255/00 ,  C07C29/141 ,  C07C29/175 ,  C07C31/125 ,  C07C33/025 ,  C07C45/512 ,  C07C45/62 ,  C07C51/235 ,  C07C51/363 ,  C07C209/26 ,  C07C227/08 ,  C07C47/21 ,  C07C47/02 ,  C07C57/03 ,  C07C53/126 ,  C07C53/19

摘要： There are disclosed a process for producing 7-octen-1-al which comprises isomerizing 2,7-octadien-1-ol in the presence of a catalyst comprising oxides of at least two metals selected from the group consisting of copper, chromium and zinc and processes for producing derivatives of 7-octen-1-al.

公开(公告)号：EP0057291A2

公开(公告)日：1982-08-11

申请号：EP81200224.4

申请日：1978-07-03

申请人： THE PROCTER & GAMBLE COMPANY

发明人： Crawford, Robert James

IPC分类号： C07B39/00 ,  C07C51/363 ,  C07C53/15 ,  C07C53/19 ,  B01J31/02

CPC分类号： B01J31/0227 ,  B01J31/0235 ,  C07B39/00 ,  C07C51/363 ,  C07C53/15 ,  C07C53/19

摘要： Catalyst system for the regiospecific halogenation containing a cyanoquinodimethane and an acidic auxiliary agent.

摘要翻译： 催化剂体系的位点特异性卤化含一个cyanoquinodimethane和在酸性助剂。

公开(公告)号：EP0057058A1

公开(公告)日：1982-08-04

申请号：EP82300123.5

申请日：1982-01-11

申请人： SANKYO COMPANY LIMITED

发明人： Morisawa, Yasuhiro c/o Central Research Lab. ,  Konishi, Kiyoshi c/o Central Reseach Lab. ,  Kataoka, Mitsuru c/o Central Research Lab.

IPC分类号： C07C69/65 ,  C07C57/54 ,  A01N37/06 ,  B27K3/34 ,  C07C103/133 ,  D21C3/08

CPC分类号： C07C57/76 ,  A01N37/06 ,  A01N37/18 ,  A01N37/22 ,  B27K3/36 ,  B27K3/40 ,  C07C51/363 ,  C07C57/52 ,  C07C57/54

摘要： A variety of organic materials susceptible to fungal attack (especially wood and wood-based materials) can be protected from such attack and fungi growing on such materials can be eradicated by treating them, e.g. by applying to the surfaces or impregnating, with one or more compounds of formula (I):
(wherein X represents a halogen atom and R represents a hydroxy group, an alkoxy group, a substituted or unsubstituted phenoxy group, an amino group, a mono or dialkylamino group, a phenylamino or benzylamino group which is unsubstituted or has one or two substituents on the benzene ring of the phenyl or benzyl moiety, or a 3-halo-2,3- diiodoallyloxy group). An anti-fungal composition contains one or more of these compounds in admixture with a carrier or adjuvant.