公开(公告)号：EP2719742B1

公开(公告)日：2016-04-27

申请号：EP12800151.8

申请日：2012-06-12

Applicant: LG Chem, Ltd.

Inventor： SHIN, Changhwan ,  KIM, Kongkyeom ,  KWON, Hyok Joon ,  LEE, Dong Hoon ,  LEE, Jinyoung ,  JANG, Boonjae ,  JANG, Jungi ,  LEE, Hyungjin

IPC: C09K11/06 ,  H01L51/50 ,  C07D487/04 ,  H01L51/00 ,  H05B33/10 ,  C09B57/00

CPC classification number: H01L51/0052 ,  C07D487/04 ,  C07F9/6561 ,  C09B57/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1044 ,  H01L51/0058 ,  H01L51/006 ,  H01L51/0068 ,  H01L51/0072 ,  H01L51/0077 ,  H01L51/0081 ,  H01L51/5072 ,  H05B33/10 ,  Y02E10/549 ,  Y10S428/917

Abstract: The present invention provides a new compound and an organic electronic device using the same. The compound according to the present invention may serve as hole injection, hole transporting, electron injection and transporting, and light emitting materials and the like in an organic electronic device comprising an organic light emitting device, and the organic electronic device according to the present invention shows excellent properties in terms of efficiency, driving voltage and service life.

公开(公告)号：EP2201025B1

公开(公告)日：2016-04-20

申请号：EP08836952.5

申请日：2008-10-13

Applicant: Kode Biotech Limited

Inventor： BOVIN, Nicolai ,  HENRY, Stephen Micheal ,  RODIONOV, Igor ,  WEINBERG, Cristina-Simona ,  TUZIKOV, Alexander Borisovich

IPC: A61K47/48 ,  C07F9/6561 ,  G01N33/80 ,  C07K7/06 ,  C07K7/08

CPC classification number: C07K7/02 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/5721 ,  C07F9/6561 ,  C07K5/02 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

Abstract translation: 本发明涉及用于实现在细胞和多细胞结构表面表达的功能部分的定性和定量变化的方法，以及用于这些方法的功能性脂质构建体。 特别地，本发明涉及功能性脂质构建体及其在诊断和治疗应用中的应用，包括血清学诊断，其中功能部分是碳水化合物，肽，化学反应性基团，共轭体或荧光团。

公开(公告)号：EP2499145B1

公开(公告)日：2016-01-27

申请号：EP10830642.4

申请日：2010-11-10

Applicant: The Regents of The University of Michigan

Inventor： WANG, Shaomeng ,  YU, Shanghai ,  SUN, Wei ,  KUMAR, Sanjeev ,  SUN, Duxin ,  ZOU, Peng ,  ZHAO, Yujun ,  MCEACHERN, Donna

IPC: C07D487/10 ,  C07D491/107 ,  C07D495/10 ,  A61K31/407 ,  A61P35/00

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

公开(公告)号：EP2970265A1

公开(公告)日：2016-01-20

申请号：EP14715529.5

申请日：2014-03-14

Applicant: PLEXXIKON INC.

Inventor： ZHANG, Jiazhong ,  BUELL, John ,  CHAN, Katrina ,  IBRAHIM, Prabha, N. ,  LIN, Jack ,  PHAM, Phuongly ,  SHI, Songyuan ,  SPEVAK, Wayne ,  WU, Guoxian ,  WU, Jeffrey

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07F9/6561 ,  A61K31/422 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/675 ,  A61K31/695 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07F7/10 ,  Y02A50/411

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract translation: 式（I）的杂环化合物，其制备方法，含有这种化合物的药物组合物及其治疗用途。

公开(公告)号：EP2876108A1

公开(公告)日：2015-05-27

申请号：EP13820327.8

申请日：2013-01-29

Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Inventor： DING, Kuiling ,  WANG, Xiaoming ,  HAN, Zhaobin ,  WANG, Xubin ,  WANG, Zheng

IPC: C07D493/10 ,  C07D493/20 ,  C07F9/6561 ,  B01J31/22 ,  C07B53/00 ,  C07C229/34 ,  C07C227/32

CPC classification number: C07D493/10 ,  B01J31/2247 ,  B01J31/2409 ,  B01J2231/32 ,  B01J2531/0238 ,  B01J2531/0261 ,  B01J2531/824 ,  C07B53/00 ,  C07C227/32 ,  C07D491/20 ,  C07D493/20 ,  C07D495/20 ,  C07F9/6561 ,  C07F9/65616 ,  C07F15/0033 ,  C07C229/34

Abstract: Disclosed are aromatic spiroketal diphosphine ligands, preparation methods and uses thereof. The ligands have the structure of formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are defined as such described in the specification. The aromatic spiroketal diphosphine ligands are prepared from aromatic spiroketal compounds. Also disclosed are the preparation methods of aromatic spiroketal compounds. The preparation methods are simple and can produce racemic or chiral aromatic spiroketal diphosphine ligands. The ligands can be used as catalysts of asymmetrical catalytic reactions having economical practicability and industry application prospect.

Abstract translation: 公开的是芳族的螺缩酮二膦配体，制备方法及其用途。 所述配体具有式（I），其中R1，R2，R3，R4，R5，R6，R7，R8，X结构和n的定义如在说明书求所述。 芳香族螺缩酮二膦配体是从芳族化合物的螺缩酮制备。 所以圆盘游离缺失是芳族化合物的螺缩酮的制备方法。 制备方法简单，并且能够产生外消旋或手性的芳族的螺缩酮二膦配体。 该配体可以被用作具有经济实用性和工业应用前景不对称催化反应的催化剂。

公开(公告)号：EP2788003A4

公开(公告)日：2015-05-27

申请号：EP12854847

申请日：2012-12-04

Applicant: DEMERX INC

Inventor： GLESS RICHARD D ,  MORIARTY ROBERT M

IPC: A61K31/65 ,  A61K31/675

CPC classification number: C07F9/6561 ,  C07D487/22

公开(公告)号：EP2670751B1

公开(公告)日：2015-04-22

申请号：EP12704960.9

申请日：2012-01-27

Applicant: Bristol-Myers Squibb Company

Inventor： TRIPP, Jonathan Clive ,  FANFAIR, Dayne Dustan ,  SCHULTZ, Mitchell J. ,  MURUGESAN, Saravanababu ,  FOX, Richard J. ,  CHEN, Chung-Pin H. ,  IVY, Sabrina E. ,  PAYACK, Joseph Francis ,  DOUBLEDAY, Wendel W.

IPC: C07D471/04 ,  C07F9/09 ,  C07F9/572 ,  C07F9/6524 ,  C07F9/6561 ,  A61K31/675 ,  A61K31/496

CPC classification number: C07D471/04 ,  C07F9/6561

公开(公告)号：EP2738176A4

公开(公告)日：2015-03-04

申请号：EP11869903

申请日：2011-07-27

Applicant: HUNAN FANGSHENGHUAMEI MEDICAL TECH CO LTD

Inventor： ZHOU WENQIANG ,  ZHANG QINGHUA ,  DENG JING

IPC: C07F9/6561 ,  A61K31/6615 ,  A61P35/00 ,  C07H15/26 ,  C07H19/10 ,  C07H19/207

CPC classification number: C07H15/26 ,  A61K31/7048 ,  C07F9/6561 ,  C07F9/65616 ,  C07H11/04 ,  C07H19/10 ,  C07H19/207

公开(公告)号：EP2809666A1

公开(公告)日：2014-12-10

申请号：EP13742931.2

申请日：2013-01-30

Applicant: The University of Hong Kong

Inventor： YANG, Dan ,  PENG, Tao ,  SHEN, Jiangang ,  CHEN, Xingmiao

IPC: C07D407/02 ,  C09K3/00 ,  B41M5/327 ,  B41M5/20

CPC classification number: G01N31/227 ,  C07D311/82 ,  C07D311/90 ,  C07D491/052 ,  C07D493/10 ,  C07D493/20 ,  C07F7/0816 ,  C07F9/6561 ,  C09B11/08 ,  C09B11/24 ,  C09B11/245 ,  C09B69/008 ,  G01N33/582 ,  G01N33/84 ,  Y10T436/170769

Abstract: Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

Abstract translation: 本文提供了可用作测量，检测和/或筛选过氧亚硝酸盐的试剂的改进的荧光化合物和探针。 本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。 本文还提供了用于在活细胞线粒体中选择性染色过氧亚硝酸盐的荧光化合物。 本文还提供了可用于直接或间接测量化学样品和生物样品（例如活生物体中的细胞和组织）中过氧亚硝酸盐的存在和/或量的方法。 还提供了用于检测或筛选过氧亚硝酸盐或可以增加或降低化学和生物样品中过氧亚硝酸盐水平的化合物的高通量筛选方法。

公开(公告)号：EP2574615B1

公开(公告)日：2014-12-10

申请号：EP11183622.7

申请日：2011-09-30

Applicant: BASF SE

Inventor： Fleckenstein, Christoph, Dr. ,  Denecke, Hartmut

IPC: C07H11/04 ,  C07F9/09

CPC classification number: C07H11/04 ,  C07F9/6561