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    METHOD OF PRETREATING VIABLE TISSUE OR CELLS TO BE CONTAINED WITHIN A SEMIPERMEABLE VESSEL
    43.
    发明公开
    METHOD OF PRETREATING VIABLE TISSUE OR CELLS TO BE CONTAINED WITHIN A SEMIPERMEABLE VESSEL 失效
    活体组织的制剂或细胞半透船舶方法。包含BE

    公开(公告)号：EP0822824A4

    公开(公告)日：2003-03-05

    申请号：EP96911636

    申请日：1996-04-05

    申请人： UNIV EMORY

    发明人： WEBER COLLIN J ,  AYERS-PRICE JENNIFER

    IPC分类号： A01N1/02 ,  A61K9/10 ,  A61K9/50 ,  A61K35/12 ,  A61K35/14 ,  A61K35/30 ,  A61K35/39 ,  A61K35/407 ,  A61P3/08 ,  A61P3/10 ,  A61P3/14 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/00 ,  C12N11/02 ,  C12N11/10

    CPC分类号： A61K9/5073 ,  A61K2035/126 ,  A61K2035/128 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/74 ,  Y10T428/2984 ,  Y10T428/2989

    摘要： A core material such as animal tissue or cells is contained within a semipermeable vessel which may be a microcapsule, hollow fiber or plastic membrane having a semipermeable wall by a method that prevents the core material from incorporation into the wall of the vessel. This is accomplished by suspending the core material in a solution of polysaccharide gum such as an alkali metal alginate in an amount between about 0.2% and about 0.5%, removing and washing the core material to remove all but a thin layer of polysaccharide gum, and gelling the polysaccharide gum with multivalent cations or other means to form a pretreated core material. The pretreated core material is contained within a semipermeable vessel such as by suspending the pretreated core material in a solution of alkali metal alginate, forming the suspension into droplets, gelling the droplets to form temporary shape-retaining capsules and treating the capsules with a polymeric material having groups that react with and crosslink acid groups of the capsules to form a permanent semipermeable membrane around the capsules. A second permanent semipermeable membrane may be formed around the capsules to form double-walled microcapsules by further treating the capsules with the polymeric material. The semipermeable vessel may be impermeable to immune factors. Cells or tissue can be transplanted from a donor to a subject such as by using pancreatic islet tissue or cells as the core material of the double-walled microcapsules and transplanting the microcapsules by intraperitoneal injection into a diabetic subject.

    LIVER TISSUE SOURCE
    44.
    发明公开
    LIVER TISSUE SOURCE 有权
    ORIGIN肝组织

    公开(公告)号：EP1252293A1

    公开(公告)日：2002-10-30

    申请号：EP01903136.8

    申请日：2001-01-19

    申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

    发明人： REID, Lola ,  LECLUYSE, Edward L.

    IPC分类号： C12N5/06 ,  A61K35/12 ,  A61K35/407 ,  G01N33/50

    CPC分类号： C12N5/0672 ,  A61K35/12

    摘要： The instant invention provides, for the first time, the use of cadaveric organs from donors with non-beating hearts as a source of functional cells such as progenitor or stem cells for various medical purposes. More specifically, a method is disclosed whereby a tissue source of progenitor cells is obtained comprising harvesting tissue from a donor, wherein the donor has a non-beating heart for as long as about thirty hours postmortem and processing the cadaveric tissue to provide progenitor cells. The instant progenitors are used for various medical purposes as means of cell therapy, gene therapy, artificial organs, bioreactors, organ regeneration and the like.

    CELLS WITH MULTIPLE ALTERED EPITOPES ON A SURFACE ANTIGEN FOR USE IN TRANSPLANTATION
    45.
    发明授权
    CELLS WITH MULTIPLE ALTERED EPITOPES ON A SURFACE ANTIGEN FOR USE IN TRANSPLANTATION 失效
    具有多表位修饰在表面抗原FOR USE IN细胞移植

    公开(公告)号：EP0752869B1

    公开(公告)日：2001-07-18

    申请号：EP95914995.6

    申请日：1995-03-30

    申请人： DIACRIN, INC.

    发明人： CHAPPEL, Scott, C.

    IPC分类号： A61K35/39 ,  A61K35/407 ,  A61K35/30 ,  A61K35/34 ,  A61K35/28

    CPC分类号： C07K16/2833 ,  A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/39 ,  A61K35/407 ,  A61K2035/122 ,  A61K2039/505 ,  C07K2317/54 ,  C12N5/0676

    摘要： Cells suitable for transplantation which have at least two different epitopes on a surface antigen altered prior to transplantation to inhibit rejection of the cells following transplantation into an allogeneic or xenogeneic recipient are disclosed. These cells are more successfully transplanted than cells which have only a single epitope on the surface antigen altered. Preferably, the antigen on the cell surface which is altered is an MHC class I antigen. Two different epitopes on an MHC class I antigen can be altered by contacting the cell with two molecules, such as antibodies or fragments thereof (e.g., F(ab')2 fragments), which bind to two different epitopes on the antigen. Preferred epitopes on human MHC class I antigens to be altered are epitopes recognized by the monoclonal antibodies W6/32 and PT85. Improved methods for transplantation utilizing cells which have at least two different epitopes on a surface antigen altered prior to transplantation are also disclosed.

    A METHOD TO INCREASE THE SURVIVAL OF TRANSPLANTED CELLS
    47.
    发明公开
    A METHOD TO INCREASE THE SURVIVAL OF TRANSPLANTED CELLS 失效
    方法增ÜBERLEBUNG移植细胞

    公开(公告)号：EP0983075A1

    公开(公告)日：2000-03-08

    申请号：EP98924669.9

    申请日：1998-05-25

    申请人： Leadd B.V.

    发明人： BRUIN, Jan, Anthonie ,  TERPSTRA, Onno

    IPC分类号： A61K35/407 ,  C12N5/06 ,  C12N5/08 ,  C12Q1/00

    CPC分类号： A61K35/407 ,  A61K35/12 ,  A61K38/00 ,  A61K2035/122 ,  C12N5/067 ,  C12N2501/585 ,  C12N2510/02

    摘要： The invention relates to the field of transplantation, specifically to the field of transplantation of isolated cells. The invention provides a method to allow cell transplantation as a method to replace organ transplantation. Anti-integrin (poly)peptides significantly block attachment of cells to both vessel walls and tissue in an in vitro binding assay. Blocking of integrins by incubation with blocking (poly)peptides significantly decreases the number of cellular aggregates after in vivo cell transplantation, and has a significant increasing effect on cellular homing in the recipient tissue. Blocking of integrin strongly improves transplanted cell survival in the recipient tissue after transplantation.