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51.发明授权Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE 失效使用表达PDGF或VEGF，愈合和组织缺损腺病毒载体，以诱导HYPERVASKULITÄT在哺乳动物组织中
公开(公告)号：EP1017421B1
公开(公告)日：2005-05-25
申请号：EP98909027.9
申请日：1998-03-06
CPC分类号： A61K35/33 , A61K35/36 , A61K38/1858 , A61K38/1866 , A61K48/00 , A61K49/0008 , C12N2799/022 , A61K2300/00
摘要： A method for repairing defects and inducing vascularization in mammalian tissue, preferably skin, involves administering to the tissue a recombinant replication defective virus, preferably adenovirus, carrying a selected growth factor gene, preferably VEGF or PDGF, under operative control of regulatory sequences which direct the expression of the growth factor(s). Also provided is a method for infecting a tissue to be transplanted with such recombinant adenoviruses prior to transplantation and, as a composition, an infected culture of human tissue to be transplanted which is infused with a selected growth factor prior to transplantation. Screening methods for the treatment of angiogenic disorders, e.g., hemangiomas and cancers, also employ an animal model on which is engrafted a full thickness human tissue infused with a growth factor.
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52.发明公开A METHOD AND DEVICE FOR ANALYSIS OF CHARGED MOLECULES BY SOLUTION ISOELECTRIC FOCUSING 有权方法和设备等电电荷的分子分析调焦一个解决方案
公开(公告)号：EP1269178A2
公开(公告)日：2003-01-02
申请号：EP01920851.1
申请日：2001-03-29
申请人： THE WISTAR INSTITUTE
发明人： SPEICHER, David, W. , ZUO, Xun
IPC分类号： G01N27/447 , C07K1/28
CPC分类号： G01N27/44773 , G01N27/44747 , G01N27/44795
摘要： The invention provides a novel solution isofocusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to complex charged molecule samples, such as eukaryotic proteome samples where reproducible resolution and quantitation of greater than 10,000 protein components is feasible.
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53.发明公开COMPOSITIONS AND METHODS TO ENHANCE SENSITIVITY OF CANCER CELLS TO MITOTIC STRESS 审中-公开组合物和方法用于增加癌细胞的敏感性的应力，有丝分裂
公开(公告)号：EP1204673A2
公开(公告)日：2002-05-15
申请号：EP00944679.0
申请日：2000-06-14
CPC分类号： C07K14/4702
摘要： An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The chfr nucleic acid and Chfr polypeptide are useful in diagnosing tumorigenic cells and in screening for drugs which can inhibit the activity of Chfr in a cancer cell, thereby rendering the cell more sensitive to additional anti-tumor therapies.
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公开(公告)号：EP1155115A1
公开(公告)日：2001-11-21
申请号：EP00911919.9
申请日：2000-02-23
CPC分类号： C12N5/0636 , A61K2035/124 , C12N5/0694 , C12N2501/23
摘要： TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of cell surface antigens, function, e.g., change in cytokine production profile, by culturing the cells in an effective amount of IL-15, optionally followed by gamma irradiation to halt proliferation.
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公开(公告)号：EP1053309A1
公开(公告)日：2000-11-22
申请号：EP99906924.8
申请日：1999-02-12
申请人： THE WISTAR INSTITUTE
发明人： HEBER-KATZ, Ellen
IPC分类号： C12N15/00 , C12N5/18 , C07K14/47 , C07K14/705 , C07K16/18 , C12Q1/68 , A01K67/027
CPC分类号： C12Q1/6883 , A01K67/027 , A61K48/005 , C12Q1/6827 , C12Q1/6881 , C12Q2600/158
摘要： Mice in which enhanced wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve wounds, are also provided.
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公开(公告)号：EP0914441A2
公开(公告)日：1999-05-12
申请号：EP97922429.0
申请日：1997-04-22
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/53 , C12N2710/16122 , C12N2710/24143 , C12N2740/16222
摘要： Novel DNA molecules for in vitro and in vivo expression of HCMV gB, gB transmembrane-deleted derivatives, pp65, pp150, and IE-exon-4 proteins are described. Preferably, the molecules are plasmids. Also described are methods of using these DNA molecules to induce immune responses to HCMV, and the use of a plasmid of the invention to prime immune responses to HCMV vaccines.
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57.发明公开MURINE AND HUMAN BOX-DEPENDENT MYC-INTERACTING PROTEIN (BIN1) AND USES THEREFOR 失效具有相关MYC相互作用蛋白（BIN1）小鼠和人类及其用途BOX
公开(公告)号：EP0828512A1
公开(公告)日：1998-03-18
申请号：EP96913924.0
申请日：1996-05-02
CPC分类号： C07K14/4703 , A61K38/00 , C07K16/18 , Y10S530/827 , Y10S530/828
摘要： A partial murine cDNA clone, a human cDNA clone, and a partial human genomic clone, each encoding a Box-dependent myc-interacting polypeptide termed Bin1, are provided. Also provided are methods of using the nucleic acid sequences, polypeptides, and antibodies directed against same in the diagnosis and treatment of cancers and hyperplastic disease states.
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公开(公告)号：EP0478146B1
公开(公告)日：1996-04-10
申请号：EP91307957.0
申请日：1991-08-30
申请人： THE WISTAR INSTITUTE
IPC分类号： C12N15/12 , C12P21/02 , C07K14/705 , C07K16/30
CPC分类号： C07K14/705 , A61K38/00 , C07K16/3046 , Y02A50/423 , Y02A50/473
摘要： The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-30 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone direct the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.
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公开(公告)号：EP0323708B1
公开(公告)日：1995-10-11
申请号：EP88311331.8
申请日：1988-11-30
发明人： Plotkin, Stanley A. , Clark, H. Fred , Offit, Paul
IPC分类号： A61K39/15
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/15 , A61K2039/542 , C12N7/00 , C12N2720/12321 , C12N2720/12322 , C12N2720/12334
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公开(公告)号：EP0602178A1
公开(公告)日：1994-06-22
申请号：EP92919946.0
申请日：1992-08-27
CPC分类号： C07K14/7051 , A61K38/00
摘要： L'invention se rapporte à un nouveau procédé de traitement de la polyarthrite rhumatoïde chez un mammifère. Le procédé consiste, par étapes, à obtenir un échantillon de synoviale prélevé chez un mammifère; à identifier dans ledit échantillon les parties variables du récepteur de lymphocytes T; et à administrer audit mammifère une quantité efficace d'anticorps sur au moins une desdites parties variables du récepteur de lymphocytes T ou des fragments antigéniques de celles-ci. L'invention concerne également un nouveau procédé pour traiter la polyarthrite rhumatoïde chez un mammifère et consistant, par étapes, à administrer audit mammifère une quantité efficace d'anticorps sur les parties variables du récepteur de lymphocytes T sélectionnés dans le groupe constitué par Valpha17, Valpha1, Vbeta12, Vbeta14, Vbeta17 et Vbeta7 et des fragments antigéniques de ceux-ci. L'invention comprend en outre un nouveau procédé destiné à immuniser un mammifère afin d'empêcher l'apparition d'une polyarthrite rhumatoïde ou afin de traiter une polyarthrite rhumatoïde évolutive. Le procédé consiste à administrer audit mammifère les parties variables du récepteur de lymphocytes T sélectionnées dans le groupe se composant de Valpha17, Valpha1, Vbeta12, Vbeta14, Vbeta17, Vbeta7 et des fragments antigéniques de celui-ci. L'invention concerne également des kits comprenant les parties variables du récepteur de lymphocytes T d'un mammifère sélectionnées dans le groupe se composant de Valpha17, Valpha1, Vbeta12, Vbeta14, Vbeta17 et Vbeta7 et des fragments antigéniques de celui-ci ou des anticorps sur lesdites parties variables.
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