公开(公告)号：EP1562971B1

公开(公告)日：2014-02-12

申请号：EP03768647.4

申请日：2003-11-04

申请人： Isis Pharmaceuticals, Inc.

发明人： ALLERSON, Charles ,  BHAT, Balkrishen ,  ELDRUP, Ann, B. ,  MANOHARAN, Muthiah ,  GRIFFEY, Richard ,  BAKER, Brenda, F. ,  SWAYZE, Eric, E.

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C12N15/1135 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/53

公开(公告)号：EP2673361A1

公开(公告)日：2013-12-18

申请号：EP12705736.2

申请日：2012-02-08

申请人： Isis Pharmaceuticals, Inc.

发明人： FREIER, Susan, M. ,  SWAYZE, Eric, E.

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3525 ,  C12N2320/50 ,  C12N2310/322 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12N2310/321 ,  C12N2310/3521

摘要： The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.

公开(公告)号：EP2606057A2

公开(公告)日：2013-06-26

申请号：EP11721849.5

申请日：2011-04-26

申请人： Isis Pharmaceuticals, Inc. ,  Alnylam Pharmaceuticals, Inc.

发明人： PRAKASH, Thazha, P. ,  SETH, Punit, P. ,  MANORHARAN, Muthiah ,  SWAYZE, Eric, E. ,  RAJEEV, Kallanthottathil, G. ,  ZLATEV, Ivan

IPC分类号： C07H19/10

CPC分类号： C07H19/10 ,  C12N15/113

摘要： Provided herein are modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom. More particularly, modified 5' diphosphate nucleosides are provided that can be further modified at the 2' and 5' positions. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds are also expected to be useful as primers and probes in diagnostic applications.

公开(公告)号：EP2114981B1

公开(公告)日：2013-05-08

申请号：EP08714113.1

申请日：2008-01-29

申请人： Isis Pharmaceuticals, Inc.

发明人： BHAT, Balkrishen ,  SWAYZE, Eric, E. ,  LIMA, Walter, F. ,  CROOKE, Stanley, T.

IPC分类号： C07H21/04 ,  C12N15/113

CPC分类号： C07H21/00 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/346 ,  C12N2310/3533

公开(公告)号：EP2580228A1

公开(公告)日：2013-04-17

申请号：EP11726017.4

申请日：2011-06-02

申请人： Isis Pharmaceuticals, Inc.

发明人： SETH, Punit, P. ,  PRAKASH, Thazha, P. ,  SWAYZE, Eric, E.

IPC分类号： C07H19/073 ,  C07H21/04 ,  C07H19/173 ,  C12N15/113

CPC分类号： C07H19/06 ,  C07H19/073 ,  C07H19/173 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341

摘要： Provided herein are 2'-amino and 2'-thio bicyclic nucleosides and oligomenc compounds prepared therefrom. The novel bicyclic nucleosides provided herein are expected to be useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as nuclease resistance.

公开(公告)号：EP2534262A2

公开(公告)日：2012-12-19

申请号：EP11740543.1

申请日：2011-02-08

申请人： Isis Pharmaceuticals, Inc. ,  The University Of British Columbia

发明人： BENNETT, C., Frank ,  HAYDEN, Michael ,  FREIER, Susan, M. ,  GREENLEE, Sarah ,  CARROLL, Jeffrey ,  WARBY, Simon ,  SWAYZE, Eric, E.

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12N15/113 ,  C12N2310/11 ,  C12N2320/34 ,  C12Q1/6811 ,  C12Q1/6897 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2525/207 ,  C12Q2535/131 ,  C12Q2539/107 ,  C12Q2521/327 ,  C12Q2525/121 ,  C12Q2525/185

摘要： Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).

公开(公告)号：EP2066684B1

公开(公告)日：2012-07-18

申请号：EP07797414.5

申请日：2007-05-10

申请人： Isis Pharmaceuticals, Inc.

发明人： SETH, Punit, P. ,  SWAYZE, Eric, E. ,  BALKRISHEN, Bhat

IPC分类号： C07H19/04 ,  C07H21/00

CPC分类号： C07H19/04 ,  C07H21/00

摘要： The present invention provides 5'-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5'-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

公开(公告)号：EP2358398A2

公开(公告)日：2011-08-24

申请号：EP09744287.5

申请日：2009-10-23

申请人： Isis Pharmaceuticals, Inc.

发明人： SWAYZE, Eric, E. ,  BHAT, Balkrishen ,  LIMA, Walter, F. ,  PRAKASH, Thazha, P. ,  KINBERGER, Garth, A.

IPC分类号： A61K48/00

CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351

摘要： The present invention provides oligomeric compounds and uses thereof. In certain embodiments, such oligomeric compounds are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.

公开(公告)号：EP2358397A2

公开(公告)日：2011-08-24

申请号：EP09744015.0

申请日：2009-10-23

申请人： Isis Pharmaceuticals, Inc.

发明人： PRAKASH, Thazha, P. ,  SWAYZE, Eric, E.

IPC分类号： A61K48/00

CPC分类号： C07H19/10 ,  A61K31/00 ,  C07H21/00

摘要： The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5′-substituent and a 2′-O-substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

摘要翻译： 本发明提供了经修饰的核苷和由其制备的低聚化合物。 更具体地，本发明提供了修饰核苷具有至少一个5“取代基，2'-O-取代的，低聚的化合物包括合成修饰的核苷以及使用所述寡聚化合物的方法中的至少一个。 在一些实施方案中，预期在所提供的低聚化合物杂交至靶RNA中的靶RNA的正常功能的丢失而导致的部分。

公开(公告)号：EP1984381B1

公开(公告)日：2010-09-29

申请号：EP07762892.3

申请日：2007-01-27

申请人： Isis Pharmaceuticals, Inc.

发明人： SWAYZE, Eric, E. ,  SETH, Punit, P.

IPC分类号： C07H19/04 ,  C07H21/00

CPC分类号： C07H21/00 ,  C07H19/00 ,  C07H19/04 ,  Y02P20/55

摘要： The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.