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公开(公告)号：EP1076563A4
公开(公告)日：2003-04-23
申请号：EP99912579
申请日：1999-03-16
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , DREWE JOHN , WANG YAN , WEBER ECKARD
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52.发明公开CASPASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY AND RADIATION THERAPY INDUCED CELL DEATH 审中-公开胱天蛋白酶抑制剂，用于治疗和预防辐射诱导的细胞死亡的化疗和
公开(公告)号：EP1220869A1
公开(公告)日：2002-07-10
申请号：EP00970773.8
申请日：2000-10-12
申请人： Cytovia, Inc.
IPC分类号： C07K5/06
CPC分类号： A61K38/05
摘要： The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy and radiation therapy and for treating and ameliorating the side effects of chemotherapy and radiation therapy of cancer is disclosed.
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53.发明公开
公开(公告)号：EP1212295A1
公开(公告)日：2002-06-12
申请号：EP00959495.3
申请日：2000-08-28
申请人： Cytovia, Inc.
发明人： WANG, Yan , CAI, Sui, Xiong , WEBER, Eckard , MILLS, Gordon, B. , GREEN, Douglas, R. , GUAN, Lufeng
IPC分类号： C07C271/28 , C07C271/12 , C07C271/22 , A61K31/195
CPC分类号： C07C271/28 , C07C271/12 , C07C271/22
摘要： The present invention is directed to novel substituted α-hydroxy acid thereof, represented by general Formula (I), where R1-R5, X and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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公开(公告)号：EP1177168A1
公开(公告)日：2002-02-06
申请号：EP00921874.4
申请日：2000-04-07
申请人： Cytovia, Inc.
IPC分类号： C07C229/00 , C07C205/00 , C07C61/08
CPC分类号： C07D295/205 , C07C237/22 , C07C271/22 , C07C311/19 , C07C2601/08 , C07C2601/14 , C07D311/16 , C07D311/66
摘要： The present invention is directed to novel dipeptide thereof, represented by general formula (I): where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
摘要翻译： 本发明涉及由通式（I）表示的新的二肽：其中R1-R3，X和Y如本文所定义。 本发明还涉及具有式（I）的化合物是半胱天冬酶和凋亡性细胞死亡的有效抑制剂的发现。 因此，本发明的抑制剂可以在发生细胞，组织或整个器官损失的多种临床疾病中延缓或阻断细胞死亡。
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公开(公告)号：EP1833511A4
公开(公告)日：2011-01-19
申请号：EP06717342
申请日：2006-01-03
申请人： MYRIAD GENETICS INC , CYTOVIA INC
IPC分类号： A01N43/54 , A61K31/4706 , A61K31/517 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/94 , A61K31/395 , C07D239/95 , C07D401/12
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56.发明公开SUBSTITUTED 3-ARYL-5-ARYL- 1,2,4 -OXADIAZOLES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开取代的3-芳基-5-芳基-1,2,4-恶二唑及其类似物作为与细胞凋亡胱天蛋白酶的活化剂的电感器和它们的用途
公开(公告)号：EP1406632A4
公开(公告)日：2009-11-04
申请号：EP02753336
申请日：2002-06-10
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , ZHANG HAN-ZHONG , DREWE JOHN A , REDDY P SANJEEVA , KASIBHATLA SHAILAJA , KUEMMERLE JARED DANIEL , OLLIS KRISTIN P
IPC分类号： C07D487/04 , A61K31/335 , A61K31/38 , A61K31/395 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/54 , A61P1/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , A61K31/415 , A61K31/4166 , A61K31/424 , A61K31/495 , A61K31/538 , A61K31/541 , A61K31/5415
CPC分类号： C07D413/14 , A61K31/335 , A61K31/38 , A61K31/395 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04
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57.发明授权
公开(公告)号：EP1212295B1
公开(公告)日：2008-10-01
申请号：EP00959495.3
申请日：2000-08-28
申请人： Cytovia, Inc.
发明人： WANG, Yan , CAI, Sui, Xiong , WEBER, Eckard , MILLS, Gordon, B. , GREEN, Douglas, R. , GUAN, Lufeng
IPC分类号： C07C271/28 , C07C271/12 , C07C271/22 , A61K31/195
CPC分类号： C07C271/28 , C07C271/12 , C07C271/22
摘要： The present invention is directed to novel substituted α-hydroxy acid thereof, represented by general Formula (I), where R1-R5, X and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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58.发明公开SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS 审中-公开取代的N-芳基 - 1H-吡唑并[3,4-b]喹啉-4-胺和它们的类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导
公开(公告)号：EP1807426A2
公开(公告)日：2007-07-18
申请号：EP05818244.5
申请日：2005-10-06
申请人： Cytovia, Inc.
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/4745 , C07D221/16
摘要： The present invention is directed to substituted N-aryl-1H-pyrazolo[3,4-b]quinolin-4-amines and analogs thereof, represented by the general Formula (I): wherein Q, Y, Z, R4-R7, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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59.发明公开4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 审中-公开4-取代的1-（亚苄基）氨基硫脲，4-取代的1-（芳基羰基）氨基硫脲和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
公开(公告)号：EP1399159A4
公开(公告)日：2007-02-14
申请号：EP02734605
申请日：2002-05-31
申请人： CYTOVIA INC
发明人： CAI SUI XIONG , NGUYEN BAO NGOC , DREWE JOHN , REDDY P SANJEEVA , KASIBHATLA SHAILAJA , PERVIN AZRA
IPC分类号： A61K31/175 , A61K31/435 , A61K31/44 , A61K31/4965 , C07C281/14 , C07C337/08 , C07D207/32 , C07D207/335 , C07D213/53 , C07D213/61 , C07D213/84 , C07D213/86 , C07D231/16 , C07D233/54 , C07D277/28 , C07D277/56 , C07D285/06 , C07D295/135 , C07D307/52 , C07D307/76 , C07D333/22 , C07D333/44 , A61K31/00 , A61P1/00 , A61P17/00 , A61P17/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07D295/12
CPC分类号： C07D207/335 , A61K31/175 , A61K31/435 , A61K31/44 , A61K31/4965 , C07C281/14 , C07C337/08 , C07C2602/42 , C07D213/53 , C07D213/61 , C07D213/84 , C07D213/86 , C07D231/16 , C07D233/64 , C07D277/28 , C07D277/56 , C07D285/06 , C07D295/135 , C07D307/52 , C07D307/76 , C07D333/22 , C07D333/44 , A61K2300/00
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60.发明授权SUBSTITUTED 2-AMINOBENZAMIDE CASPASE INHIBITORS AND THE USE THEREOF 有权取代的2- AMINOBENZAMIN蛋白酶抑制剂及其用途
公开(公告)号：EP1165490B1
公开(公告)日：2006-08-16
申请号：EP00917859.1
申请日：2000-03-15
申请人： Cytovia, Inc.
IPC分类号： C07C229/00 , C07C69/74 , C07C205/00 , A01N37/10 , A01N37/12 , A01N37/00
CPC分类号： C07D333/38 , C07C271/22 , C07C271/24 , C07C271/28 , C07C2601/08 , C07C2601/14
摘要： The present invention is directed to novel 2-aminobenzamide thereof, represented by general Formula (I) where R1-R3, X and A-D are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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