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    IMPROVED APPARATUS FOR ELECTRICALLY MEDIATED DELIVERY OF THERAPEUTIC AGENTS
    53.
    发明公开
    IMPROVED APPARATUS FOR ELECTRICALLY MEDIATED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
    改进的设备用于药物的电介导的递送

    公开(公告)号：EP2929909A1

    公开(公告)日：2015-10-14

    申请号：EP15165174.2

    申请日：2005-03-08

    申请人： Ichor Medical Systems Inc.

    发明人： Masterson, Steven P. ,  Hannaman, Andrew W. ,  Bernard, Robert M.

    IPC分类号： A61N1/32 ,  A61N1/08 ,  A61N1/30

    CPC分类号： A61N1/0502 ,  A61N1/08 ,  A61N1/30 ,  A61N1/325 ,  A61N1/327

    摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.

    SYSTEM FOR PREVENTING BACTERIAL INFECTIONS IN NEEDLE TRAJECTORIES
    55.
    发明公开
    SYSTEM FOR PREVENTING BACTERIAL INFECTIONS IN NEEDLE TRAJECTORIES 有权
    系统ZUR VERHINDERUNG VON BAKTERIELLEN INFEKTIONEN BEINADELDURCHGÄNGEN

    公开(公告)号：EP2913007A1

    公开(公告)日：2015-09-02

    申请号：EP13849478.6

    申请日：2013-10-22

    申请人： Universitat Pompeu Fabra

    发明人： IVORRA CANO, Antonio ,  CASTELLVI FERNANDEZ, Quim

    IPC分类号： A61B10/02 ,  A61B18/14

    CPC分类号： A47F5/112 ,  A47F5/11 ,  A61B10/0241 ,  A61B10/0275 ,  A61B2010/009 ,  A61B2017/00889 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61M37/00 ,  A61N1/0502 ,  F16B12/00

    摘要： The invention relates to a system for the prevention of needle tract bacterial infections, comprising:
    - a percutaneous surgical instrument (1) percutaneously introducible into a tissue (3) of a patient, such as a biopsy needle, and having an outer surface made of an electrically conductive material;
    - a contact electrode (4) applicable to the skin (3a) of a patient;
    - a silver coating or silver element (P) arranged on or forming part of the instrument (1), and configured, sized and provided so as to break down by means of electrochemical release when a current is applied thereto, releasing silver ions into its surroundings; and
    - an electric current generator (2) arranged and configured for generating a current and inducing the temporary circulation thereof between the instrument (1) acting as an anode, the tissue (3) and the contact electrode (4) acting as a cathode, respectively, with a magnitude and duration which are determined for producing a massive and sudden release of silver ions for the purpose of preventing post-treatment bacterial infections.

    摘要翻译： 本发明涉及一种用于预防针头细菌感染的系统，包括： - 经皮外科器械（1）经皮导入患者的组织（3），例如活检针，并且具有由 导电材料; - 适用于患者皮肤（3a）的接触电极（4）; - 布置在仪器（1）上或形成仪器（1）的一部分上的银涂层或银元件（P），并且被配置为尺寸设置成当施加电流时通过电化学释放而分解，将银离子释放到其中 环境; 以及 - 电流发生器（2），被布置和构造成用于产生电流并引起作为阳极的器具（1），组织（3）和用作阴极的接触电极（4）之间的临时循环， 分别具有确定用于产生大量和突然释放银离子以防止治疗后细菌感染的量级和持续时间。

    SYSTEMS AND METHODS FOR PERCUTANEOUS ELECTRICAL STIMULATION
    60.
    发明公开
    SYSTEMS AND METHODS FOR PERCUTANEOUS ELECTRICAL STIMULATION 审中-公开
    系统VERFAHRENFÜRPERKUTANE ELEKTROSTIMULIERUNG

    公开(公告)号：EP2563456A4

    公开(公告)日：2014-02-12

    申请号：EP11777968

    申请日：2011-04-27

    申请人： NDI MEDICAL LLC

    发明人： RUNDLE KENNETH ,  GALECKI STEVEN ,  MARKS MICHAEL ,  MRVA JOSEPH ,  SAKAI JONATHAN ,  STROTHER ROBERT B

    IPC分类号： A61N1/00 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36

    CPC分类号： A61N1/0504 ,  A61N1/0492 ,  A61N1/0502 ,  A61N1/36017 ,  A61N1/36021 ,  H01R43/00 ,  Y10T29/49117

    摘要： Systems and methods according to the present invention relate to a substantially extracorporeal pulse generator system for electrical stimulation of one or more target nerve or their branches using one or more preferably percutaneous leads each having one or more electrodes implanted in, on, around, or near the target nerve. Improved systems include a patch assembly configured to be adhesively mounted to a patient's skin and an electrical stimulation assembly configured to be mechanically mounted to the patch assembly. A preferred patch assembly, in addition to provide mechanical mounting of the stimulation assembly, provides a power source for the stimulation assembly, and may further serve as a return electrode. Associated system components and methods of use are also provided.

    摘要翻译： 根据本发明的系统和方法涉及一种基本上体外的脉冲发生器系统，其用于使用一个或多个优选经皮引线对一个或多个靶神经或其分支进行电刺激，所述一个或多个优选经皮引线各自具有一个或多个电极，其中， 目标神经。 改进的系统包括构造成粘合地安装到患者皮肤的贴片组件和被配置为机械地安装到贴片组件的电刺激组件。 除了提供刺激组件的机械安装之外，优选的贴片组件提供用于刺激组件的电源，并且还可以用作返回电极。 还提供了相关的系统组件和使用方法。