公开(公告)号：EP2024360A2

公开(公告)日：2009-02-18

申请号：EP07870684.3

申请日：2007-05-15

申请人： Cephalon, Inc.

发明人： BACON, Edward R. ,  BAILEY, Thomas R. ,  BECKNELL, Nadine C. ,  GINGRICH, Diane E. ,  HOSTETLER, Greg ,  HUDKINS, Robert L. ,  LEARN, Keith S. ,  WAGNER, Jason C.

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D473/00 ,  C07D487/04 ,  A61K31/517 ,  A61K31/52 ,  A61P3/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D487/04

摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).

公开(公告)号：EP2023932A1

公开(公告)日：2009-02-18

申请号：EP07797607.4

申请日：2007-05-21

申请人： Trustees of Dartmouth College

发明人： DELEO, Joyce, A.

IPC分类号： A61K31/522 ,  C07D473/00

CPC分类号： A61K31/522

摘要： The present invention is a method for preventing or treating acute and chronic pain. Using an agent to increase the expression or activity of GLT-1, behavioral hypersensitivity is attenuated thereby preventing or treating acute and chronic pain in a subject in need of such treatment. Methods for identifying agents that prevent or treat acute and chronic pain through modulation of the expression or activity of GLT-1 or the GLT-1 pathway are also provided.

公开(公告)号：EP2013199A1

公开(公告)日：2009-01-14

申请号：EP07845239.8

申请日：2007-04-19

申请人： NOVARTIS AG

发明人： FAIRHURST, Robin, Alec ,  TAYLOR, Roger, John

IPC分类号： C07D403/08 ,  C07D473/00 ,  A61K31/52

CPC分类号： C07D473/34 ,  C07D473/40

摘要： A compound of formula (I) and their preparation and use as pharmaceuticals wherein R1, R2 and R3 are as defined herein.

公开(公告)号：EP2012799A2

公开(公告)日：2009-01-14

申请号：EP07760797.6

申请日：2007-04-18

申请人： Chimerix, Inc. ,  The Regents Of The University Of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  RUIZ, Jacqueline ,  ALMOND, Merrick R. ,  PAINTER, George R. ,  RILEY, Timothy, A. ,  FRANCOM, Paula

IPC分类号： A61K31/675 ,  C07F9/40 ,  C07D473/00 ,  C07D473/34 ,  C07D239/47 ,  C07D239/52

CPC分类号： C07F9/65121 ,  C07F9/6552 ,  C07F9/65616 ,  C07F9/657172

摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.

公开(公告)号：EP1719765A4

公开(公告)日：2009-01-07

申请号：EP05710452

申请日：2005-02-15

申请人： BANYU PHARMA CO LTD

发明人： OTAKE NORIKAZU ,  OGINO YOSHIO BANYU ,  KANATANI AKIO BANYU

IPC分类号： C07D235/14 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/437 ,  A61K31/454 ,  A61K31/496 ,  A61K31/52 ,  A61K31/55 ,  A61P9/00 ,  C07D235/10 ,  C07D401/04 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D235/14 ,  C07D473/00 ,  C07D487/04

摘要： Disclosed is a compound represented by the following general formula (I). (I) [In the formula, A, B, C and D independently represent an optionally substituted methine group or a nitrogen atom and at least one of them represents a methine group; E represents a group represented by one of the following formulae (E1): (E1) ; R1 represents a lower alkyl group, an optionally substituted aryl group or a lower alkylene group to be bonded to an arbitrary portion of E which is capable of forming a bond.] This compound is useful as an agent for the treatment of various diseases associated with NPY.

公开(公告)号：EP1976849A2

公开(公告)日：2008-10-08

申请号：EP07709799.6

申请日：2007-01-16

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K.C. ,  YANG, De-Yi ,  KIM, Seong-Heon ,  SHANKAR, Bandarpalle, B. ,  SIDDIQUI, M., Arshad ,  ROSNER, Kristin, E. ,  DAI, Chaoyang ,  POPOVICI-MULLER, Janeta ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  RIZVI, Razia ,  MICULA, Aneta, S ,  FELTZ, Robert

IPC分类号： C07D401/14 ,  C07D403/06 ,  A61P35/00 ,  A61K31/4166 ,  C07D471/04 ,  C07D473/34 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症的式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体 。

公开(公告)号：EP1954681A2

公开(公告)日：2008-08-13

申请号：EP06848736.2

申请日：2006-11-15

申请人： National Jewish Medical and Research Center

发明人： DAY, Brian J. ,  KACHADOURIAN, Remy

IPC分类号： C07D233/70 ,  C07D233/54 ,  C07D263/32 ,  C07D277/24 ,  C07D261/08 ,  C07D473/00 ,  C07D209/86 ,  A61K31/33 ,  A61P35/00

CPC分类号： C07D233/70 ,  A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/635 ,  A61K2121/00 ,  C07D209/86 ,  C07D233/64 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D473/00

摘要： Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e., ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.

公开(公告)号：EP1939196A1

公开(公告)日：2008-07-02

申请号：EP06126797.7

申请日：2006-12-21

申请人： ESTEVE QUIMICA, S.A.

发明人： Medrano Rupérez, Jorge ,  Campon, Julio ,  Elías Rius, Laia ,  Berenguer Maimó, Ramón

IPC分类号： C07D473/00

CPC分类号： C07D473/00

摘要： Process for the preparation of abacavir starting from compound of formula (IV) where R 1 is a (C 1 -C 4 )-alkyl radical comprising first reacting said compound (IV) with anhydrous hydrochloric acid/(C 1 -C 6 )-alcohol, and then with tri(C 1 -C 4 )-alkyl orthoformate, in the absence of water, followed by reacting the compound obtained with cyclopropylamine and hydrolysing the compound obtained to yield abacavir or its salts.

摘要翻译： 其中R 1为（C 1 -C 4） - 烷基的式（Ⅳ）化合物的制备阿巴卡韦的方法包括首先使所述化合物（Ⅳ）与无水盐酸/（C 1 -C 6） - 醇，然后在不存在水的情况下与三（C 1 -C 4）烷基原甲酸酯反应，然后使得到的化合物与环丙胺反应，并水解得到的化合物，得到阿巴卡韦或其盐。

公开(公告)号：EP1891042A2

公开(公告)日：2008-02-27

申请号：EP06754018.7

申请日：2006-05-31

申请人： UCB Pharma, S.A.

发明人： KENDA, Benoît ,  QUESNEL, Yannick ,  ATES, Ali ,  MICHEL, Philippe ,  TURET, Laurent ,  MERCIER, Joël

IPC分类号： C07D401/06 ,  C07D403/06 ,  C07D473/00 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/433 ,  A61K31/435

CPC分类号： C07D513/04 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

摘要： The present invention concerns 2-oxo-1 -pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP1881988A1

公开(公告)日：2008-01-30

申请号：EP06759506.6

申请日：2006-05-10

申请人： MERCK SHARP & DOHME LTD. ,  NEUROGEN CORPORATION

发明人： BROWN, Rebecca Elizabeth ,  HUMPHRIES, Alexander Charles ,  ROGERS, Lauren ,  BAYLISS, Tracy ,  JONES, A., Brian ,  MOYES, Christopher Richard ,  HOLLINGWORTH, Gregory John ,  BLUM, Charles, A. ,  ZHENG, Xiaozhang ,  BAKTHALVATCHALAM, Rajagopal ,  CAPITOSTI, Scott

IPC分类号： C07D495/04 ,  C07D513/04 ,  C07D473/00 ,  A61K31/495 ,  A61P11/00 ,  A61P29/00

CPC分类号： C07D495/04 ,  C07D473/00 ,  C07D513/04

摘要： The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).