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74 条记录 (耗时 0.033 秒)

    PHARMACEUTICAL COMPOSITION AND MANUFACTURING METHOD THEREFOR
    64.
    发明公开
    PHARMACEUTICAL COMPOSITION AND MANUFACTURING METHOD THEREFOR 有权
    药剂师联合医药大学

    公开(公告)号：EP2687218A1

    公开(公告)日：2014-01-22

    申请号：EP12831559.5

    申请日：2012-09-07

    申请人： Saisei Mirai Clinic ,  The University of Tokushima

    发明人： UTO, Yoshihiro ,  HORI, Hitoshi ,  INUI, Toshio ,  KUBO, Kentaro

    IPC分类号： A61K35/16 ,  A61P31/00 ,  A61P35/00

    CPC分类号： C07K14/765 ,  A61K35/16 ,  A61K38/47

    摘要： An object of the present invention is to provide a pharmaceutical composition comprising an enzyme-treated human serum which is useful for treatment and prevention of diseases such as a cancer and an infectious disease, and a method of preparing the same. The present invention relates to a method of preparing a pharmaceutical composition comprising an enzyme-treated human serum, comprising a step of bringing the human serum into contact with β-galactosidase and, to a pharmaceutical composition comprising an enzyme-treated human serum obtained by the preparation method.

    摘要翻译： 本发明的目的是提供一种药物组合物及其制备方法，其包含可用于治疗和预防诸如癌症和感染性疾病的疾病的经酶处理的人血清。 本发明涉及一种制备包含经酶处理的人血清的药物组合物的方法，包括使人血清与β-半乳糖苷酶接触的步骤，以及包含经酶处理的人血清的药物组合物 制备方法。

    DEVICE FOR MEASURING RADIATION INTENSITY OF SMALL SEALED RADIOACTIVE SOURCE FOR CANCER THERAPY
    65.
    发明公开
    DEVICE FOR MEASURING RADIATION INTENSITY OF SMALL SEALED RADIOACTIVE SOURCE FOR CANCER THERAPY 审中-公开
    设备测量小的辐射强度加封为癌症治疗的放射源

    公开(公告)号：EP2508917A1

    公开(公告)日：2012-10-10

    申请号：EP10834379.9

    申请日：2010-11-30

    申请人： The University of Tokushima

    发明人： SAZE, Takuya ,  NAKAYAMA, Shintaro ,  FURUTANI, Shunsuke ,  KUWAHARA, Yoshinori ,  MORIMOTO, Tsutomu ,  KINOSHITA, Yusuke ,  KUROSAKI, Yutaka ,  YAMADA, Takaharu ,  SHINOHARA, Toshinori

    IPC分类号： G01T7/00 ,  A61N5/10

    CPC分类号： A61N5/1048 ,  A61N5/1075 ,  A61N2005/1019

    摘要： Provided is a radiation intensity measuring apparatus for an encapsulated sealed radioactive source for brachytherapy capable of easily and accurately measuring radiation intensity of sources with a cartridge enclosed under sterile conditions.
    The radiation intensity measuring apparatus for sources S loaded in a cartridge C includes radiation intensity measuring means for measuring radiations emitted from the source S, holding means 30 for holding the cartridge C, and moving means for moving the holding means 30 to the radiation intensity measuring means. The moving means includes a guide portion for guiding the movement of the holding means 30 so that the holding means 30 moves along a direction perpendicular to an axial direction of a slit 15h, and a moving portion for moving the holding means 30 so that all the sources loaded in the cartridge C pass through a position of the slit 15h in housing space of a housing portion.

    摘要翻译： 提供了一种用于对能够在无菌条件下封闭的盒源轻松且准确地设定测量的辐射强度的近程放射治疗包封密封放射源的辐射强度测量设备。 用于在盒式磁带C的装填源S上的辐射强度的测量装置包括：辐射强度测量装置，用于测量从源极S发射的辐射，保持装置30，用于保持暗盒C，和移动装置，用于移动该夹持装置30的辐射强度测量 手段。 移动装置包括用于引导所述保持的移动的引导部是指垂直于沿一个方向30个，从而DASS模具保持装置30移动在狭缝15h的轴向方向，以及用于移动所述保持的移动部分的装置30做了所有的 在盒C的装填源通过在壳体部的收纳空间的狭缝15h的位置。

    CHEMICALLY CURABLE GLASS-IONOMER CEMENT
    66.
    发明授权
    CHEMICALLY CURABLE GLASS-IONOMER CEMENT 有权
    化学固化玻璃离子水门汀

    公开(公告)号：EP2011469B1

    公开(公告)日：2012-06-27

    申请号：EP07742320.0

    申请日：2007-04-24

    申请人： The University of Tokushima

    发明人： ARITA, Kenji

    IPC分类号： A61K6/083 ,  A61L24/12 ,  A61K6/027 ,  A61K6/033

    CPC分类号： A61L24/12 ,  A61K6/033 ,  A61K6/0835 ,  C08L33/08

    摘要： [PROBLEMS] To overcome all of the disadvantages of a light-curable glass-ionomer cement (GIC), and to provide a high-quality, safe chemically curable GIC which has a similar level of mechanical strength to that of a light-curable one and retains the characteristic properties and advantages of a GIC. [MEANS FOR SOLVING PROBLEMS] A chemically curable glass-ionomer cement comprising a microparticulate hydroxyapatite, wherein the microparticulate hydroxyapatite has an average particle diameter of not smaller than 0.6 μm and less than 100 μm and is made so porous as to increase its specific surface area.

    ANTIGEN-AND-DRUG VEHICLE COMPRISING SYNTHETIC PEPTIDE, AND MUCOSAL VACCINE USING THE SAME
    68.
    发明公开
    ANTIGEN-AND-DRUG VEHICLE COMPRISING SYNTHETIC PEPTIDE, AND MUCOSAL VACCINE USING THE SAME 有权
    抗原和药物车辆，合成肽，并使用该疫苗SANTANDER粘膜

    公开(公告)号：EP2281574A1

    公开(公告)日：2011-02-09

    申请号：EP09728744.5

    申请日：2009-03-30

    申请人： The University of Tokushima

    发明人： KIDO, Hiroshi ,  TAKEI, Tsunetomo ,  MIZUNO, Dai

    IPC分类号： A61K39/39 ,  A61K39/12 ,  A61P31/00 ,  A61P31/16 ,  A61P37/08 ,  A61P43/00 ,  C07K7/08 ,  C07K14/00

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/541 ,  A61K2039/6018 ,  A61K2039/6031 ,  C07K7/08 ,  C07K14/001 ,  C12N2760/16134

    摘要： Disclosed are an antigen-and-drug (AD) vehicle and a mucosal vaccine utilizing a novel synthetic peptide.
    The antigen-and-drug (AD) vehicle capable of inducing the production of secretory IgA antibodies, which is a complex of a synthetic peptide having the following amino acid sequence: PVHLKRLm (m is 11 to 15 or 16 to 20, e.g., peptide of SEQ. ID. NO: 1) or KnLm (n is 4 to 8 and m is 11 to 20, e.g., peptide of (SEQ. ID. NO: 2 or 3), and a lipid(s). The mucosal vaccines is obtainable by allowing a mucosal-immunity-IgA-inducing amount of an antigen to coexist with, contact, be captured by, or be adsorbed onto the AD vehicle.

    摘要翻译： 本发明公开了在抗原和药物（AD）赋形剂和粘膜疫苗利用一个新的合成肽。 的抗原和药物（AD）载体能够诱导产生分泌型IgA抗体的，所有这些是具有以下氨基酸序列的合成肽的复合物：PVHLKRLm（m是11至15或16至20，例如，肽 （n为4〜8，m为11至20，例如，（SEQ ID NO：2或肽3）：NO SEQ ID 1的）或KnLm，和脂质（一个或多个）所述的粘膜疫苗。 是通过使抗原的粘膜免疫-IgA的诱导量的，接触共存，由被捕获，或放在AD车辆被吸附而得到的。

    DETERMINATION METHOD FOR ALLERGIC DISEASE
    70.
    发明公开
    DETERMINATION METHOD FOR ALLERGIC DISEASE 有权
    BESTIMMUNGSVERFAHRENFÜREINE ALLERGISCHE ERKRANKUNG

    公开(公告)号：EP2136211A1

    公开(公告)日：2009-12-23

    申请号：EP08710396.6

    申请日：2008-02-15

    申请人： The University of Tokushima ,  Oriental Yeast Co., Ltd.

    发明人： KIDO, Hiroshi ,  SUZUKI, Koichi

    IPC分类号： G01N33/53 ,  G01N21/78 ,  G01N33/531 ,  G01N33/543

    CPC分类号： G01N33/6854 ,  G01N33/54373

    摘要： It is to provide a method for determining allergic diseases with a high sensitivity and accuracy which enables multilateral and global analysis with a minute amount of sample, even using body fluid other than blood such as saliva, nasal discharge and tears as a sample, particularly by suppressing nonspecific reaction as much as possible. A chemically modified diamond/DLC (Diamond-like Carbon) chip is activated with a reacting reagent, a coupling reaction with a peptide comprising allergen or allergen epitope is conducted, and a sample such as saliva, tears, and nasal discharge which has undergone pressure filtration with a low protein-adsorbing filter, is contacted with an allergen determination chip to which washing and blocking operations have been performed on unreacted active groups, and an allergen recognizing antibody in the sample captured by the allergen determination chip is detected by immunoassay using a labeled secondary antibody, wherein a glycine-containing solution is used for a washing solution and/or blocking solution used in the washing and blocking operations, is used.

    摘要翻译： 它是提供一种以高灵敏度和精确度确定过敏性疾病的方法，其能够使用少量样品进行多边和全球分析，甚至使用血液以外的体液（如唾液，鼻腔排泄物和泪液）作为样品，特别是通过 尽可能地抑制非特异性反应。 用反应试剂激活化学改性的金刚石/ DLC（类金刚石碳）芯片，进行与包含变应原或变应原表位的肽的偶联反应，以及经历压力的样品例如唾液，泪液和鼻放电 与低蛋白质吸附过滤器的过滤与已对未反应的活性基团进行洗涤和封闭操作的变应原测定芯片接触，并且通过免疫测定法检测由变应原测定芯片捕获的样品中的变应原识别抗体，使用 使用其中含有甘氨酸的溶液用于洗涤和阻塞操作中使用的洗涤溶液和/或封闭溶液。