公开(公告)号：EP1863839B1

公开(公告)日：2010-08-04

申请号：EP06725149.6

申请日：2006-03-20

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper ,  DÖRWALD, Florencio Zaragoza ,  STEPHENSEN, Henrik ,  BLOCH, Paw ,  HANSEN, Thomas, Kruse ,  MADSEN, Kjeld

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61K47/48

CPC分类号： C07K14/605 ,  A61K38/00

公开(公告)号：EP1704165B1

公开(公告)日：2010-03-17

申请号：EP04803037.3

申请日：2004-12-17

申请人： NOVO NORDISK A/S

发明人： JOHANSEN, Nils Langeland ,  LAU, Jesper ,  MADSEN, Kjeld ,  HANSEN, Thomas Kruse ,  STURIS, Jeppe

IPC分类号： C07K14/605 ,  C07K14/575 ,  A61K38/26 ,  A61K38/22

CPC分类号： C07K14/57563 ,  A61K38/00 ,  C07K14/605

摘要： Novel GLP-1 compounds and their therapeutic use.

公开(公告)号：EP2118083A1

公开(公告)日：2009-11-18

申请号：EP08701308.2

申请日：2008-01-08

申请人： Novo Nordisk A/S

发明人： MURRAY, Anthony ,  LAU, Jesper ,  VEDSØ, Per

IPC分类号： C07D277/48 ,  C07D417/12 ,  A61K31/427 ,  A61P3/10

CPC分类号： C07D277/48 ,  C07D417/12

摘要： This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of various diseases, e.g. for the treatment of type 2 diabetes. Further encompassed is a pharmaceutical composition comprising a compound according to the invention and a process for preparing such.

公开(公告)号：EP1996224A1

公开(公告)日：2008-12-03

申请号：EP07726938.9

申请日：2007-03-15

申请人： Novo Nordisk A/S

发明人： SCHLEIN, Morten ,  HANSEN, Thomas Kruse ,  LAU, Jesper ,  LUDVIGSEN, Svend

IPC分类号： A61K38/28 ,  A61K38/22 ,  A61K47/10

CPC分类号： A61K38/28 ,  A61K9/0019 ,  A61K38/22 ,  A61K2300/00

摘要： The present invention relates to a soluble pharmaceutical composition for parenteral administration, which comprises an amylin peptide, and a meal-related insulin peptide, and to the use of such compositions for treatment of e.g. hyperglycemia.

公开(公告)号：EP1940880A2

公开(公告)日：2008-07-09

申请号：EP06807132.3

申请日：2006-10-11

申请人： Novo Nordisk A/S

发明人： LAU, Jesper

IPC分类号： C07K16/18 ,  C07K16/24 ,  C07K14/715 ,  A61K39/395 ,  A61K38/17 ,  A61P3/10

CPC分类号： C07K16/245 ,  C07K14/7155 ,  C07K2319/00

摘要： The present invention describes a method of treating diabetes or metabolic syndrome with a compound that inhibits (a) IL-1, (b) the synthesis of IL-1, or (c) the release of IL-1.

公开(公告)号：EP1799710A2

公开(公告)日：2007-06-27

申请号：EP05794484.5

申请日：2005-10-07

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper ,  HANSEN, Thomas, Kruse

IPC分类号： C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00

摘要： Novel protracted GLP-1 compounds and therapeutic uses thereof.

公开(公告)号：EP1723128A1

公开(公告)日：2006-11-22

申请号：EP05700554.8

申请日：2005-01-06

申请人： NOVO NORDISK A/S

发明人： MURRAY, Anthony ,  LAU, Jesper ,  JEPPESEN, Lone ,  VEDSO , Per ,  ANKERSEN, Michael ,  LUNDBECK, Jane, Marie ,  KRISTIANSEN, Marit ,  VALCARCE-LOPEZ, Maria Carmen ,  POLISETTI, Dharma, Rao ,  SUBRAMANIAN, Govindan ,  ANDREWS, Robert, Carl ,  CHRISTEN, Daniel, P. ,  COOPER, Jeremy, T. ,  SANTHOSH, Kalpathy, Chidambareswaran

IPC分类号： C07D277/48 ,  C07D277/56 ,  C07D285/12 ,  C07D277/82 ,  C07D241/20 ,  C07D285/08 ,  C07D277/60 ,  C07D213/75 ,  C07D233/88 ,  C07D271/08 ,  C07D261/14 ,  C07D417/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

CPC分类号： C07D417/12 ,  A61K31/4168 ,  A61K31/427 ,  A61K31/433 ,  C07D213/75 ,  C07D233/88 ,  C07D241/20 ,  C07D261/14 ,  C07D271/08 ,  C07D277/48 ,  C07D277/56 ,  C07D277/60 ,  C07D277/82 ,  C07D285/08 ,  C07D285/135 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

摘要： This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R1 and R2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial .

公开(公告)号：EP1704165A1

公开(公告)日：2006-09-27

申请号：EP04803037.3

申请日：2004-12-17

申请人： NOVO NORDISK A/S

发明人： JOHANSEN, Nils Langeland ,  LAU, Jesper ,  MADSEN, Kjeld ,  HANSEN, Thomas Kruse ,  STURIS, Jeppe

IPC分类号： C07K14/605 ,  C07K14/575 ,  A61K38/26 ,  A61K38/22

CPC分类号： C07K14/57563 ,  A61K38/00 ,  C07K14/605

摘要： Novel GLP-1 compounds and their therapeutic use.

公开(公告)号：EP1696962A2

公开(公告)日：2006-09-06

申请号：EP04803038.1

申请日：2004-12-17

申请人： NOVO NORDISK A/S

发明人： HANSEN, Thomas Kruse ,  ZUNDEL, Magali ,  MADSEN, Kjeld ,  SVENDSEN, Anne ,  SCHIODT, Christine Bruun ,  LAU, Jesper

IPC分类号： A61K47/48 ,  C07K14/47 ,  C07K14/605 ,  A61K38/26 ,  A61K38/38 ,  C07K14/765 ,  C07K19/00 ,  A61P3/10

CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K47/643 ,  C07K14/46 ,  C07K14/4705 ,  C07K14/57563 ,  C07K2319/00

摘要： The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR is the remains of a reactive residue that has formed a covalent bond with an amino acid residue of the protraction protein, and protraction protein is a protein having a molar weight of at least 5 kDa, having a plasma halflife of at least 24 hours in human plasma , and said protraction protein has been synthesised by a non-mammalian organism or synthetically.

公开(公告)号：EP1453541A1

公开(公告)日：2004-09-08

申请号：EP02781171.0

申请日：2002-12-03

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper

IPC分类号： A61K45/06 ,  A61P3/10 ,  A61P3/06

CPC分类号： C07D403/04 ,  A61K31/16 ,  A61K31/18 ,  A61K31/195 ,  A61K31/198 ,  A61K31/405 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/18 ,  C07D405/04 ,  C07D409/04 ,  C07D409/06 ,  A61K2300/00

摘要： The invention relates to the use of a combination of a glucokinase activator and a glucagon antagonist for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity and inhibiting the activity of glucagon is beneficial, such as for management, treatment, control, or adjunct treatment of type 1 diabetes or type 2 diabetes.