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126 条记录 (耗时 0.03 秒)

    REMEDY
    61.
    发明公开
    REMEDY 审中-公开
    补救

    公开(公告)号：EP1535891A1

    公开(公告)日：2005-06-01

    申请号：EP03765309.4

    申请日：2003-07-17

    申请人： TAKARA BIO INC.

    发明人： OHNOGI, Hiromu ,  SUGIYAMA, Katsumi ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C07C35/44 ,  A61K31/704 ,  A61K31/56 ,  A61P9/00 ,  A61P25/00 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  A23L1/30 ,  C07H15/256 ,  C07J63/00

    CPC分类号： C07J63/00 ,  A23L33/10 ,  A61K31/56 ,  A61K31/704 ,  C07H15/256 ,  A61K2300/00

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor (NGF) production upon treatment or prevention, an enhancing agent for nerve growth factor production, and a food, beverage or feed for enhancing nerve growth factor production, characterized in that each comprises as an effective ingredient a compound selected from the group consisting of soyasaponin compounds, soyasapogenin compounds, glycyrrhizin and salts thereof. In addition, the present invention relates to a novel soyasaponin compound and a novel soyasapogenin compound, having an action for enhancement of NGF production.

    摘要翻译： 本发明涉及用于治疗或预防时需要增强神经生长因子（NGF）产生的疾病的治疗剂或预防剂，神经生长因子产生的增强剂和用于增强神经生长因子的食物，饮料或饲料 其特征在于各自包含选自大豆皂苷化合物，大豆皂草苷化合物，甘草甜素及其盐的化合物作为有效成分。 另外，本发明涉及具有增强NGF产生作用的新型大豆皂苷化合物和新型大豆皂草苷原化合物。

    METHOD OF EXTENDED CULTURE FOR ANTIGEN-SPECIFIC CYTOTOXIC T LYMPHOCYTES
    63.
    发明公开
    METHOD OF EXTENDED CULTURE FOR ANTIGEN-SPECIFIC CYTOTOXIC T LYMPHOCYTES 有权
    延胡索酮抗生素抗生素ZYTOTOXISCHE T-LYMPHOZYTEN

    公开(公告)号：EP1424387A1

    公开(公告)日：2004-06-02

    申请号：EP02762780.1

    申请日：2002-08-15

    申请人： TAKARA BIO INC.

    发明人： SAGAWA, Hiroaki ,  IDENO, Mitsuko ,  KATO, Ikunoshin

    IPC分类号： C12N5/02 ,  C12N5/06 ,  A61K35/14 ,  A61P35/00

    CPC分类号： C12N5/0636 ,  A61K2039/515 ,  A61K2039/5158 ,  C12N2501/105 ,  C12N2501/12 ,  C12N2501/23 ,  C12N2501/515 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/905

    摘要： The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.

    摘要翻译： 本发明是诱导具有抗原特异性细胞毒活性的细胞毒性T细胞的方法，用于维持细胞的方法，连续培养细胞的方法或扩增细胞的方法，包括培养细胞毒性T细胞的步骤 在至少一种选自（A）与CD44具有结合活性的物质的物质的存在下， （B）能够调节通过将CD44配体结合到CD44而发射的信号的物质; （C）能够抑制生长因子与生长因子受体结合的物质; （D）能够调节由生长因子与生长因子受体结合而发出的信号的物质; 和（E）纤连蛋白，其片段或其混合物。

    METHOD OF AMPLIFYING NUCLEIC ACID
    67.
    发明公开
    METHOD OF AMPLIFYING NUCLEIC ACID 审中-公开
    Verfahren zur Amplifikation vonNukleinsäuren

    公开(公告)号：EP1312682A1

    公开(公告)日：2003-05-21

    申请号：EP01956988.8

    申请日：2001-08-21

    申请人： TAKARA BIO INC.

    发明人： SAGAWA, Hiroaki ,  UEMORI, Takashi ,  MUKAI, Hiroyuki ,  YAMAMOTO, Junko ,  TOMONO, Jun; ,  KOBAYASHI, Eiji ,  ENOKI, Tatsuji ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12Q1/68 ,  C12N15/09

    CPC分类号： C12Q1/6853

    摘要： A method of highly sensitively and specifically amplifying a target nucleic acid in a sample by using a chimeric oligonucleotide primer having a ribonucleotide provided at the 3'-terminus or in the 3'-terminal side, an endoribonuclease and a DNA polymerase having a chain transfer activity, i.e., an isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN) method; a method of detecting an amplified fragment obtained by using the above method; a process for producing a target nucleic acid by using the above amplification method; and chimeric oligonucleotide primers to be used in these methods.

    摘要翻译： 通过使用具有在3'末端或3'末端侧提供的核糖核苷酸的嵌合寡核苷酸引物，内切核糖核酸酶和具有链转移的DNA聚合酶，高度灵敏地且特异性地扩增样品中的靶核酸的方法 活性，即核酸的等温和嵌合引物启动扩增（ICAN）方法; 检测通过使用上述方法获得的扩增片段的方法; 通过使用上述扩增方法制备靶核酸的方法; 和用于这些方法的嵌合寡核苷酸引物。

    METHOD OF DETECTING CANCER
    70.
    发明授权
    METHOD OF DETECTING CANCER 有权
    检测方法的癌症的

    公开(公告)号：EP1304377B1

    公开(公告)日：2008-10-22

    申请号：EP01984244.2

    申请日：2001-07-18

    申请人： TAKARA BIO INC.

    发明人： TSUBOSA, Yasuhiro ,  AOYAGI, Kazuhiko ,  SASAKI, Hiroki ,  TERADA, Masaaki ,  MINENO, Junichi ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12N15/12 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/158

    摘要： A method of selecting a marker gene which is useful in identifying cancer; a method of identifying cancer by using this gene; a method of detecting cancer, a kit to be used in the identification or detection method; and a DNA array holding the above gene. Thus, it is possible to obtain a gene which shows a change in the expression dose independently from a gene showing a change in the expression specifically at the proliferation of cells and specifically to each cancer sample. Use of this gene makes it possible to conveniently and quickly identify or detect cancer withou resort to any surgical operations, thereby contributing to the diagnonis and treatment of cancer, etc.