公开(公告)号：EP1325751A4

公开(公告)日：2005-05-04

申请号：EP01972593

申请日：2001-09-28

申请人： DAIICHI SEIYAKU CO ,  EGASHIRA KENSUKE

发明人： EGASHIRA KENSUKE ,  TAKESHITA AKIRA ,  KOYANAGI MASAMICHI ,  NAKAMUTA MAKOTO ,  NISHIDA KENICHI

IPC分类号： A61K38/19 ,  A61K48/00 ,  A61P1/16 ,  A61P43/00 ,  A61K45/00

CPC分类号： A61K38/195 ,  A61K48/00

摘要： Preventives and/or remedies for liver diseases containing as the active ingredient monocyte chemoattractant protein-1 (MCP-1) function inhibitors. Administration of the MCP-1 function inhibitors exerts effects of preventing and/or treating liver diseases.

公开(公告)号：EP1161956A4

公开(公告)日：2005-03-16

申请号：EP00909677

申请日：2000-03-16

申请人： DAIICHI SEIYAKU CO

发明人： NAKAGAMI HIROAKI ,  SUZUKI TATSUYA ,  KOBAYASHI HIDEO ,  KUROSAWA AKIRA

IPC分类号： A61K47/44 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/195 ,  A61K31/4015 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  A61K47/10 ,  A61P31/10 ,  B01J2/00 ,  B01J2/02 ,  A61K31/4402 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/554 ,  A61K31/704 ,  A61K31/7048 ,  A61K47/30

CPC分类号： A61K9/0095 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/5026 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551

摘要： Granular medicinal compositions containing a drug having an offensive taste, a waxy substance and a sugar alcohol; a process for producing the same and oral medicinal preparations containing these compositions. Because of having an excellent effect of masking the offensive taste of the drug and a good feel in using, these preparations can be easily taken by aged persons, children and patients with difficulty in swallowing. These preparations are suitable for tube administration too.

公开(公告)号：EP1260585A4

公开(公告)日：2005-02-02

申请号：EP01906253

申请日：2001-02-23

申请人： DAIICHI SEIYAKU CO

发明人： SUZUKI MAKOTO ,  ISHIBASHI KEN ICHI

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  G01N33/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K16/18 ,  G01N33/6863

摘要： A novel mechanical stimulus-responsive channel protein originating in mouse or humans which is expressed specifically in the kidney and has a function of non-selectively incorporating cation into cells respondent to a mechanical stimulus; a DNA encoding this protein; a method of screening a cation channel activity enhancer or inhibitor with the use of this protein; and an antibody against this protein. The above-described protein is useful as a diagnostic or a remedy for diseases based on abnormalities in the cation channel such as hypertension or diabetes or as a tool for searching for preventives and/or remedies for these diseases.

公开(公告)号：EP1155702A4

公开(公告)日：2004-12-15

申请号：EP99952805

申请日：1999-10-29

申请人： DAIICHI SEIYAKU CO

发明人： SUSAKI HIROSHI ,  INOUE KAZUHIRO ,  KUGA HIROSHI ,  IKEDA MASAHIRO ,  SHIOSE YOSHINOBU ,  KORENAGA HIROSHI

IPC分类号： A61K31/4745 ,  A61K47/48 ,  C08B37/02 ,  C07D491/22 ,  C08B37/00

CPC分类号： A61K31/4745 ,  A61K47/61 ,  A61K47/65 ,  C08B37/0021

摘要： A method for assaying a DDS compound containing a saccharide compound-modified carboxy C1-4 alkyldextran polyalcohol and a drug compound residue bonded to this carboxy C1-4 alkyldextran polyalcohol, or a DDS compound wherein a polymer carrier is bonded to a drug compound residue via a spacer containing 2 to 8 amino acids bonded together via peptide bonds, which involves the step of assaying a hydrolysate obtained by treating the DDS compound with peptidase.

公开(公告)号：EP0982037A4

公开(公告)日：2004-10-13

申请号：EP99909244

申请日：1999-03-19

申请人： DAIICHI SEIYAKU CO

发明人： TANI TOHRU ,  KONDO HIROYUKI

IPC分类号： A61K38/22 ,  A61K38/00 ,  A61K38/18 ,  A61P31/04 ,  A61K38/17

CPC分类号： A61K38/1833

摘要： Novel preventives and/or remedies for sepsis. The above preventives and/or remedies contain as the active ingredient tumor cytotoxic factor-II (TCF-II) and exert particularly excellent effects on sepsis caused by at least one factor selected from the group consisting of infectious disease, burn, operation, cancer, acquired immunological deficiency syndrome (AIDS), radiation therapy, chemotherapy and total parenteral nutrition (TPN).

公开(公告)号：EP1310487A4

公开(公告)日：2004-03-03

申请号：EP01954496

申请日：2001-08-07

申请人： DAIICHI SEIYAKU CO

发明人： NAKAYAMA KEIJI ,  MUTO MAKOTO ,  SAITO TATSURU ,  TANI YUICHIRO ,  AKIBA TOSHIFUMI

IPC分类号： C07D209/54 ,  C07C45/64 ,  C07C45/38 ,  C07C47/293 ,  C07C47/37 ,  C07C209/48 ,  C07C211/18 ,  C07C253/16 ,  C07C255/31

CPC分类号： C07D209/54

摘要： Processes for preparing intermediate compounds (VII) and compounds (VIII) and (XIV), which are useful as raw materials in the synthesis of antimicrobial compounds, from compounds (I) or (X) trough compounds (II); and novel compounds useful in the processes.

公开(公告)号：EP1221445A4

公开(公告)日：2003-05-28

申请号：EP00966445

申请日：2000-10-12

申请人： DAIICHI SEIYAKU CO

发明人： SOGA TSUNEHIKO ,  UOTO KOUICHI ,  TAKEDA YASUYUKI

IPC分类号： A61K31/337 ,  A61K31/4355 ,  A61P35/00 ,  C07D305/14 ,  C07D493/04

CPC分类号： C07D493/04 ,  A61K31/4355

摘要： Novel Taxol derivatives having various substituents as represented by general formula (I) and being usable as antitumor compounds which can be orally administered.

公开(公告)号：EP0936215A4

公开(公告)日：2002-10-30

申请号：EP97939188

申请日：1997-09-05

申请人： DAIICHI SEIYAKU CO

发明人： YOKOYAMA YUKIO ,  KOBAYASHI TATSUYA ,  KOYAMA TAKEO

IPC分类号： C07C253/30 ,  C07C255/50 ,  C07C255/52 ,  C07D207/12 ,  C07C17/06 ,  C07D207/16

CPC分类号： C07C255/50 ,  C07C253/30 ,  C07D207/12 ,  Y02P20/55 ,  C07C255/52

摘要： A process for preparing compounds represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1 represents a nitrogen protective group; R2 represents a methanesulfonyl or p-toluenesulfonyl group; R3 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms, and X represents a halogen atom. The above process is useful as a commercial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Laid-Open No. 208946/1993.

摘要翻译： 制备下列反应路线中通式（5）和（6）代表的化合物或其盐的方法，其中R1代表氮保护基; R2代表甲磺酰基或对甲苯磺酰基; R3表示氢原子，芳烷基或具有1至6个碳原子的烷基，并且X表示卤素原子。 上述方法作为制备日本专利公开208946/1993中描述的抗凝血芳族脒衍生物中间体的商业方法是有用的。

公开(公告)号：EP1020189A4

公开(公告)日：2002-07-31

申请号：EP98931103

申请日：1998-07-14

申请人： DAIICHI SEIYAKU CO

发明人： REGAN CIARAN ,  O'GORMAN DAVID ,  O'CONNELL ALAN ,  SHIOTANI TADASHI

IPC分类号： A61K31/40

CPC分类号： A61K31/40

摘要： A pharmaceutical which is useful for prevention and/or treatment of amnesia attributable to an intravenously administrable anaesthetic, for example, propofol, and contains as the active ingredient a compound represented by the general formula: R -CH2CONH-R (wherein R represents a pyridyl group, a substituted pyridyl group, a phenyl group, or a substituted phenyl group; and R represents an optionally substituted 2-oxo-1-pyrrolidinyl group), for example, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide.

公开(公告)号：EP1142575A4

公开(公告)日：2002-07-24

申请号：EP00900360

申请日：2000-01-13

申请人： DAIICHI SEIYAKU CO

发明人： HAYASHI KEIJI ,  ARISAWA HIROHIKO ,  MASUNAGA HIROAKI

IPC分类号： A61K31/00 ,  A61K31/435 ,  A61K31/439 ,  A61P17/00 ,  A61P17/16 ,  C07D497/20

CPC分类号： C07D497/20

摘要： Novel dry skin remedies useful for the treatment of dry skin, containing as the active ingredient spiro[oxathiolane-quinuclidine] derivatives represented by general formula (I) or acid addition salts thereof, desirably cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride. The remedies promote the secretion of sebaceous and sweat glands through oral or parenteral administration to treat dry skin, thus being useful as drugs.