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472 条记录 (耗时 0.026 秒)

    COMPOSITIONS AND METHODS FOR ALTERING RNAI
    62.
    发明公开
    COMPOSITIONS AND METHODS FOR ALTERING RNAI 审中-公开
    组合物和方法中应用RNA干扰

    公开(公告)号：EP1976566A2

    公开(公告)日：2008-10-08

    申请号：EP06839414.7

    申请日：2006-12-19

    申请人： Northwestern University

    发明人： CARTHEW, Richard ,  LEE, Young, Sik ,  HARRIS, Dinari

    IPC分类号： A61K48/00

    CPC分类号： C12N5/0601 ,  C07K14/43581 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/12 ,  C12N2320/50 ,  G01N33/5023 ,  G01N33/5041

    摘要： The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPSl and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to alter (e.g., enhance) RNAi. The present invention also provides methods of identifying inhibitors (e.g., small molecule, nucleic acid (e.g., siRNA), and antibody) of RNAi regulators and methods of using the same (e.g., to enhance RNAi). Compositions and methods of the present invention find use in research (e.g., functional genomics), therapeutic (e.g., drug discovery and delivery) and clinical applications.

    Treatment of neoplastic diseases using a combination of plasminogen activators and sulfhydryl donors
    65.
    发明公开
    Treatment of neoplastic diseases using a combination of plasminogen activators and sulfhydryl donors 失效
    使用纤溶酶原激活剂和Sulfhydryldonoren的组合肿瘤性疾病的治疗

    公开(公告)号：EP1705184A1

    公开(公告)日：2006-09-27

    申请号：EP06112574.6

    申请日：1997-09-17

    申请人： Northwestern University

    发明人： SOFF, Gerald ,  Gatley, Stephen T. ,  Twardowski, Przemyslaw

    IPC分类号： C07K14/00 ,  A61K38/00 ,  C07K14/47 ,  C12N9/68 ,  A61K38/48 ,  C12N9/72

    CPC分类号： A61K38/49 ,  A61K38/166 ,  A61K48/00 ,  C12N9/6435 ,  C12Y304/21007 ,  A61K2300/00

    摘要： The invention provides methods of generating angiostatin in vitro comprising contacting plasminogen with a plasminogen activator and a sulfhydryl donor or contacting plasmin with a sulfhydryl donor. The invention also provides a method of treating angiogenic diseases by administering to an animal suffering from such a disease a sulfhydryl donor and, optionally, a plasminogen activator, plasminogen or plasmin. The invention further comprises a composition for generating angiostatin comprising a sulfhydryl donor and a plasminogen activator. The invention also provides a container holding a sulfhydryl donor and/or a plasminogen activator, said container having a label thereon instructing administration of the sulfhydryl donor and/or plasminogen activator to an animal suffering from an angiogenic disease. The invention further provides plasminogen fragments-whose N-terminal amino acid is the same as that of plasmin and whose C-terminal amino acid is located in kringle 5 and which inhibit angiogenesis, antibodies which bind selectively to these fragments, methods and kits for using the antibodies, methods and materials for making the fragments by recombinant DNA techniques, and a method of treating an angiogenic disease comprising administering an effective amount of one of the fragments. Finally, the invention provides a method of treating an angiogenic disease comprising administering a transgene coding for one of the fragments.

    摘要翻译： 本发明提供了产生在体外血管抑素包括使纤溶酶原与纤溶酶原激活物和巯基供体或具有巯基供体接触纤溶酶的方法。 因此本发明提供了通过从寻求巯供体的疾病和，任选地，纤溶酶原激活剂，纤溶酶原或纤溶酶给予动物治疗患有血管生成性疾病的方法。 本发明还包括用于产生血管抑素包括巯基供体和纤溶酶原激活剂的组合物。 因此本发明提供一种容器保持巯供体和/或纤溶酶原激活剂，在其上具有由在血管发生性疾病指示巯基供体和/或纤溶酶原激活剂的施用给动物的痛苦的标签，所述容器。 本发明进一步提供纤维蛋白溶酶原片段谁的N-末端氨基酸是相同的象纤溶酶和谁的C-末端氨基酸位于三环5和抑制血管生成，选择性结合到合成片段，方法的抗体和试剂盒使用 所述抗体，方法和用于通过重组DNA技术制备的片段的材料，和血管发生性疾病，其包括有效量的片段之一的给药的治疗的方法。 最后，本发明提供了血管生成性疾病，包括施用的转基因编码的片段中的一个的处理的方法。

    Globular assembly of amyloid beta protein and uses thereof
    66.
    发明公开
    Globular assembly of amyloid beta protein and uses thereof 无效
    Globularer Aufbau vom淀粉样蛋白β-蛋白和deren Verwendungen

    公开(公告)号：EP1571158A2

    公开(公告)日：2005-09-07

    申请号：EP04027742.8

    申请日：2000-08-04

    申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA ,  Northwestern University

    发明人： Kraft, Grant A. ,  Klein, William L. ,  Chromy, Brett A. ,  Lambert, Mary P. ,  Finch, Caleb E. ,  Morgan, Todd ,  Wals, Pat ,  Rozovsky, Irina ,  Barlow, Ann

    IPC分类号： C07K14/47 ,  A61K38/04 ,  G01N33/68

    CPC分类号： C07K14/4711 ,  A61K38/00

    摘要： The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembly bled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

    摘要翻译： 本发明提供了包含淀粉样蛋白²蛋白质组装的淀粉样蛋白β衍生的痴呆配体（ADDL），其引入能够激活特定细胞过程的球状非纤维寡聚结构中。 本发明提供了用于测定ADDL的形成，存在，受体蛋白结合和细胞活性的方法，以及阻断ADDL的形成或活性的化合物以及鉴定这些化合物的方法。 本发明进一步提供使用ADDL的方法，以及调节ADDL形成和/或活性，特别是在学习和/或记忆障碍的治疗中。

    ELECTROSTATICALLY DRIVEN LITHOGRAPHY
    67.
    发明公开
    ELECTROSTATICALLY DRIVEN LITHOGRAPHY 有权
    静电驱动平版印刷

    公开(公告)号：EP1509816A2

    公开(公告)日：2005-03-02

    申请号：EP03796269.3

    申请日：2003-05-21

    申请人： NORTHWESTERN UNIVERSITY

    发明人： Lim, Jung-Hyurk ,  Mirkin, Chad A.

    IPC分类号： G03F7/20 ,  B82B3/00 ,  G03F7/16

    CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03B27/42 ,  G03F7/164

    摘要： A method of nanolithography comprising: transporting a patterning compound from a nanoscopic tip to a substrate to form a pattern on the substrate, wherein the patterning compound has a first electrostatic charge and the substrate has a second electrostatic charge which is opposite to the first electrostatic charge. The patterning compound can be an electrically conductive polymer having a charged polymer backbone. The patterns can be dots and lines having lateral dimensions of less than one micron. No electrical bias from an external voltage source between the tip and the substrate is needed.

    摘要翻译： 一种纳米光刻的方法，包括：将图案化化合物从纳米级尖端输送到基底以在所述基底上形成图案，其中所述图案化化合物具有第一静电电荷，并且所述基底具有与所述第一静电荷相反的第二静电电荷 。 构图化合物可以是具有带电聚合物主链的导电聚合物。 图案可以是横向尺寸小于1微米的点和线。 尖端和基板之间不需要来自外部电压源的电偏压。