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    TERPENE GLYCOSIDES AND THEIR COMBINATIONS AS SOLUBILIZING AGENTS
    74.
    发明公开
    TERPENE GLYCOSIDES AND THEIR COMBINATIONS AS SOLUBILIZING AGENTS 审中-公开
    萜甙和其组合作为溶剂

    公开(公告)号：EP2445535A2

    公开(公告)日：2012-05-02

    申请号：EP10792655.2

    申请日：2010-06-24

    申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

    发明人： LIU, Zhijun

    IPC分类号： A61K47/36

    CPC分类号： A61K47/26 ,  A61K31/00 ,  A61K31/12

    摘要： Several terpene glycosides (e.g., mogroside V, paenoiflorin, geniposide, rubusoside, rebaudioside A, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, celecoxib, clofazimine, digoxin, oleandrin, nifedipine, and amiodarone. The use of the diterpene glycoside rubusoside and monoterpene glycoside paenoiflorin increased solubility in all tested compounds. The terpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries.

    Herbicide resistant rice
    77.
    发明公开
    Herbicide resistant rice 失效
    Herbizid抗力Reis

    公开(公告)号：EP2202301A1

    公开(公告)日：2010-06-30

    申请号：EP08022284.7

    申请日：1997-04-28

    申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

    发明人： Croughan, Timothy P.

    IPC分类号： C12N15/00 ,  C12N15/01 ,  C12N15/05 ,  A01H1/00 ,  A01H1/06 ,  A01H4/00 ,  A01H5/00

    CPC分类号： A01H5/10 ,  C12N9/88 ,  C12N15/8278

    摘要： Rice plants are disclosed with two separate, but synergistic mechanisms for resistance to herbicides that normally inhibit a plant's acetohydroxyacid synthase (AHAS) enzyme. The herbicide resistance of plants with both resistance mechanisms is substantially greater than one would expect from a simple combination of the two types of resistance. The first of the two resistance mechanisms is a metabolic pathway that is not fully understood, but that does not itself involve a mutant AHAS enzyme. The second resistance mechanism is a mutant AHAS enzyme, an enzyme that shows direct resistance to levels of herbicide that normally inhibit the enzyme, in both in vivo and in vitro assays. Besides controlling red rice, many AHAS-inhibiting herbicides also effectively control other weeds that are common in rice fields.; Several of these herbicides have residual activity, so that a treatment controls both existing weeds as well as weeds that sprout later. No herbicide currently available for use on rice has residual activity against a broad spectrum of weeds including red rice. With effective residual activity against red rice and other weeds, rice producers now have a weed control system superior to those currently used.

    摘要翻译： 公开了水稻植物，其具有通常抑制植物的乙酰羟酸合酶（AHAS）酶的除草剂抗性的两种分开但协同的机制。 具有两种抗性机制的植物的除草剂抗性基本上大于从两种类型的抗性的简单组合所预期的。 两种抗性机制中的第一种是尚未完全了解的代谢途径，但本身并不涉及突变型AHAS酶。 第二种抗性机制是一种突变体AHAS酶，一种在体内和体外测定中显示出对通常抑制酶的除草剂水平的直接抗性的酶。 除了控制红米外，许多AHAS抑制性除草剂还有效地控制了稻田中常见的其他杂草。 这些除草剂中的几种具有残留活性，因此处理控制现有的杂草以及随后发芽的杂草。 目前没有可用于水稻的除草剂对广泛的杂草（包括红米）具有残留活性。 对于红米和其他杂草具有有效的残留活性，水稻生产者现在具有优于目前使用的杂草控制系统。