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公开(公告)号：EP0993307A2
公开(公告)日：2000-04-19
申请号：EP97911600.1
申请日：1997-10-01
IPC分类号： A61K51/08
CPC分类号： C07K7/56 , A61K51/08 , A61K51/082 , A61K51/088 , C07K14/75
摘要： The present invention describes novel radiopharmaceuticals of formula (I), wherein J, K, L, and M are amino acids or derivatives thereof and R', R1, R2 and n are as defined herein, that are radiolabeled cyclic compounds containing chelators which act as antagonists of the platelet glycoprotein IIb/IIIa complex, methods of using the same as imaging agents for the diagnosis of arterial and venous thrombi, and novel reagents for the preparation of the same and kits comprising the reagents.
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72.发明公开AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN 失效AMIDINOINDOLE，AMIDINOAZOLE及其类似物Xa因子和凝血酶的抑制剂
公开(公告)号：EP0960102A1
公开(公告)日：1999-12-01
申请号：EP97933214.0
申请日：1997-06-30
发明人： DOMINGUEZ, Celia , HAN, Qi , DUFFY, Daniel, Emmett , PARK, Jeongsook, Maria , QUAN, Mimi, Lifen , ROSSI, Karen, Anita , WEXLER, Ruth, Richmond
IPC分类号： A61K31 , A61P7 , A61P43 , C07D209 , C07D231 , C07D235 , C07D307 , C07D333 , C07D401 , C07D403 , C07D405 , C07D471
CPC分类号： C07D333/58 , C07D209/18 , C07D231/56 , C07D235/06 , C07D307/79 , C07D401/06 , C07D401/12 , C07D403/12 , C07D463/06 , C07D471/04
摘要： The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W?1, W2, and W3¿ are selected from CH and N, provided that one of W?1 and W2¿ is C(C(=NH)NH¿2?) and at most two of W, W?1, W2, and W3¿ are N and one of J?a and Jb¿ is substituted by -(CH¿2?)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.
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公开(公告)号：EP0946508A1
公开(公告)日：1999-10-06
申请号：EP97952409.0
申请日：1997-12-15
发明人： PINTO, Donald, Joseph, Phillip , PRUITT, James, Russell , CACCIOLA, Joseph , FEVIG, John, Matthew , HAN, Qi , ORWAT, Michael, James , QUAN, Mimi, Lifen , ROSSI, Karen, Anita
IPC分类号： C07D409 , C07D413 , A61K31 , A61P7 , A61P43 , C07D207 , C07D231 , C07D233 , C07D249 , C07D257 , C07D401 , C07D403 , C07D417 , C07D521
CPC分类号： C07D257/04 , C07D207/34 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/40 , C07D231/42 , C07D233/56 , C07D233/90 , C07D249/06 , C07D249/08 , C07D249/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D417/12
摘要： The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
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公开(公告)号：EP0944619A1
公开(公告)日：1999-09-29
申请号：EP97950692.0
申请日：1997-11-26
IPC分类号： A61K31 , A61P7 , A61P9 , A61P19 , A61P27 , A61P35 , A61P43 , C07D215 , C07D401 , C07D413 , C07D417 , C07D471
CPC分类号： C07D401/12 , C07D215/56 , C07D413/14
摘要： This invention relates to novel fused heterocycles which are useful as antagonists of the αvβ3 and related integrin receptors of Formula (I), to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
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75.发明公开(4R,5S,6S,7R)-HEXAHYDRO-1- 5-(3-AMINOINAZOLE)METHYL] -3-BUTYL-5,6-DIHYDROXY-4,7-BIS PHENYLMETHYL] -2H-1,3-DIAZEPIN-2-ONE, ITS PREPARATION AND ITS USE AS HIV PROTEASE INHIBITOR 失效（4R，5S，6S，7R） - 六氢-1-¬5-（3- AMINOINAZOLE）甲基丁基-5,6-二羟基-4,7-双¬PHENYLMETHYL-2H-1,3-二氮杂-2-ON ITS生产与应用，HIV蛋白酶抑制剂
公开(公告)号：EP0937066A1
公开(公告)日：1999-08-25
申请号：EP97945596.0
申请日：1997-11-04
CPC分类号： C07D403/06
摘要： The present invention relates to compounds of formula (I) or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
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76.发明公开
公开(公告)号：EP0901476A1
公开(公告)日：1999-03-17
申请号：EP97916985.0
申请日：1997-03-25
发明人： RAJAGOPALAN, Parthasarathi , CHORVAT, Robert, John , BAKTHAVATCHALAM, Rajagopal , BECK, James, Peter , GILLIGAN, Paul, Joseph , OLSON, Richard, Eric
CPC分类号： C07D239/34 , C07D239/47 , C07D239/48 , C07D239/545 , C07D487/04
摘要： Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by this invention are those of formulae (I), (II) wherein R1, R13, X, Y, Z, G and Q are as defined herein.
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公开(公告)号：EP1226123A1
公开(公告)日：2002-07-31
申请号：EP00976822.7
申请日：2000-11-02
IPC分类号： C07D231/14 , A61P7/02 , C07D401/12 , C07D249/10 , C07D403/12
CPC分类号： C07D401/12 , C07D231/14 , C07D249/10 , C07D403/12
摘要： The present application desscribes inhibitors of factor Xa which are cyano-pyrazole, cyano-triazole, cyano-imidazole, and cyano-pyrrole compounds of Formulae (Ia), (Ib), (Ic), and (Id): or pharmaceutically acceptable salt forms thereof.
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78.发明公开1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS 审中-公开作为HIV抑制剂逆转SUITABLE 1,4-苯并二氮杂-2-酮酶
公开(公告)号：EP1183242A2
公开(公告)日：2002-03-06
申请号：EP00941135.6
申请日：2000-05-19
IPC分类号： C07D243/14 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06 , A61K31/5513 , A61P31/18
CPC分类号： C07D401/06 , C07D243/14 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
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公开(公告)号：EP1175419A2
公开(公告)日：2002-01-30
申请号：EP00923096.2
申请日：2000-03-30
IPC分类号： C07D417/12 , C07D417/14 , C07D409/12 , C07D409/14 , A61K31/428 , A61K31/4155 , A61K31/423 , A61K31/275 , A61K31/33 , A61P7/02
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present application describes aryl sulfonyls of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa inhibitors.
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80.发明公开N-ADAMANT-1-YL-N'- 4-CHLOROBENZOTHIAZOL-2-YL] UREA USEFUL IN THE TREATMENT OF INFLAMMATION AND AS AN ANTICANCER RADIOSENSITIZING AGENT 审中-公开的N-金刚烷-1-基 - ¬4氯 - 苯并噻唑-2-基脲FOR USE IN炎症的治疗并作为抗恶性肿瘤药RADIOSENSIBILISIERENDES
公开(公告)号：EP1165531A1
公开(公告)日：2002-01-02
申请号：EP00915010.3
申请日：2000-03-15
IPC分类号： C07D277/82 , A61K31/428 , A61P29/00 , A61P35/00
CPC分类号： C07D277/82
摘要： This invention relates generally to N-adamant-1-yl-N'-[4-chlorobenzolthiazol-2-yl] urea, pharmaceutical compositions comprising the same, and methods of using the same in the treatment of inflammation and as an anticancer radiosensitizing agent.
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