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公开(公告)号：EP0799317B1
公开(公告)日：2004-04-28
申请号：EP95944594.1
申请日：1995-11-15
申请人： ZymoGenetics, Inc.
CPC分类号： C12N9/6459 , C07K14/524 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C07K2319/75 , C12N15/625 , C12Y304/21069
摘要： DNA constructs useful in the production of thrombopoietin are disclosed. In general, the DNA constructs comprise a first DNA segment encoding a fusion of an amino-terminal secretory peptide joined to a thrombopoietin polypeptide and one or more additional DNA segments that provide for the transcription of the first segment. The secretory peptide is a native mammalian t-PA secretory peptide or may be modified to enhance proteolytic cleavage of the fusion. Also disclosed are cultured eukaryotic cells containing these DNA constructs and methods for producing thrombopoietin polypeptides through the use of the DNA constructs and cultured eukaryotic cells.
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72.发明公开
公开(公告)号：EP1385979A2
公开(公告)日：2004-02-04
申请号：EP02723832.8
申请日：2002-04-12
申请人： ZymoGenetics, Inc.
发明人： POWNDER, Tracey, A. , CHAN, Chung
摘要： The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by improving translation from expression cassettes in vitro before producing recombinant hosts.
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公开(公告)号：EP1370676A2
公开(公告)日：2003-12-17
申请号：EP02733813.6
申请日：2002-03-04
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , XU, Wenfeng , KINDSVOGEL, Wayne , CHEN, Zhi
CPC分类号： C07K14/7155 , A01K2217/05 , A01K2217/075 , C07K2319/00 , Y10S530/81
摘要： Cytokine and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as 'mouse Zcytor16,' which can bind and antagonize the IL-TIF cytokine.
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公开(公告)号：EP1337267A1
公开(公告)日：2003-08-27
申请号：EP01992584.1
申请日：2001-11-05
申请人： ZymoGenetics, Inc.
CPC分类号： A61K38/45 , A61K2300/00
摘要： Use of factor XIII for treating hemophilia A. A patient having hemophilia A is treated by administering factor XIII generally in conjunction with factor VIII or desmopressin.
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75.发明公开
公开(公告)号：EP1323823A2
公开(公告)日：2003-07-02
申请号：EP03002314.7
申请日：1998-07-02
申请人： Zymogenetics Inc
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Antibodies, antibody fragments or single chain antibodies that specifically bind to human and mouse orthologs of the Zsig-9 secreted polypeptide are provided, the antibodies are preferably monoclonal. Also provided are methods of using the antibodies of the invention as well as in-vitro methods of diagnosing cancer in human tissues or body fluids utilising the antibodies of the invention or antisense nucleic acid sequences that specifically bind to Zsig-9 polynucleotide sequences. The invention is of particular use in diagnosing cancers such as brain tumour, liver tumour, lung tumour, esophageal tumour, stomach tumour, colon tumour, rectal tumour, thyroid tumour, or lymphoma tumour.
摘要翻译： 抗体，抗体片段或单链抗体并以设置在ZSIG-9分泌的多肽的人类和小鼠直系同源物特异性结合，所述抗体优选是单克隆的。 所以提供了使用本发明的抗体以及在体外在人组织或利用本发明或反义核酸序列的抗体体液诊断癌症的方法都特异性结合ZSIG-9的序列的多核苷酸的方法。 本发明是在诊断癌症特别有用的：如脑肿瘤，肝肿瘤，肺肿瘤，食管肿瘤，胃肿瘤，结肠肿瘤，直肠肿瘤，甲状腺瘤，或淋巴瘤肿瘤。
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公开(公告)号：EP1246843A1
公开(公告)日：2002-10-09
申请号：EP01901722.7
申请日：2001-01-04
申请人： ZymoGenetics, Inc.
发明人： CONKLIN, Darrell, C.
IPC分类号： C07K14/50 , A61K38/18 , C07K16/22 , A61K39/395
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/00 , C12N2799/022
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF12 a novel member of the FGF family. The present invention also includes antibodies to the zFGF12 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：EP1237921A1
公开(公告)日：2002-09-11
申请号：EP00973811.3
申请日：2000-10-23
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , LOFTON-DAY, Catherine, E. , HENNE, Randall , PRESNELL, Scott, R. , YAO, Yue , NOVAK, Julia, E. , FOSTER, Donald, C. , YEE, David, P.
CPC分类号： C07K14/7151
摘要： Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonist. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
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公开(公告)号：EP1228215A1
公开(公告)日：2002-08-07
申请号：EP00939889.2
申请日：2000-06-14
申请人： ZymoGenetics, Inc.
发明人： CONKLIN, Darrell, C. , GAO, Zeren
CPC分类号： C07K14/52
摘要： Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
摘要翻译： 公开了新颖的细胞因子多肽，制备它们的材料和方法以及使用方法。 多肽包含SEQ ID NO：2或SEQ ID NO：4的至少九个连续的氨基酸残基，并且可以制备为多肽融合物，其包含异源序列，例如亲和标签。 编码它们的多肽和多核苷酸可用于各种治疗，诊断和研究应用。
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公开(公告)号：EP1228211A2
公开(公告)日：2002-08-07
申请号：EP00980335.4
申请日：2000-11-09
申请人： ZymoGenetics, Inc.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/574 , A01K67/027
CPC分类号： C07K14/4702
摘要： The present invention relates to polynucleotide and polypeptide molecules for zmse1, a novel human CRIB protein. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The present invention also includes antibodies to the zmse1 polypeptides.
摘要翻译： 本发明涉及新型人CRIB蛋白zmse1的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸可用于检测人类染色体异常和癌症。 本发明还包括zmse1多肽的抗体。
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公开(公告)号：EP1190056A1
公开(公告)日：2002-03-27
申请号：EP00947028.7
申请日：2000-06-30
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/7155 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as 'Zcytor14'.
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