-
公开(公告)号：EP3695836A1
公开(公告)日：2020-08-19
申请号：EP20150114.5
申请日：2014-03-14
IPC分类号： A61K31/337 , A61K31/397 , A61K31/439 , A61K31/445 , A61K31/4545 , C07D205/06 , A61P35/00 , A61P29/00 , A61P25/30 , A61P37/00 , A61P25/28 , A61P31/04 , A61P31/12
摘要： Proivded herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
-
公开(公告)号：EP3075386B1
公开(公告)日：2019-10-16
申请号：EP16153694.1
申请日：2010-06-17
发明人： LEBOWITZ, Jonathan , CHANG, Byeong
-
73.发明公开
公开(公告)号：EP3479842A2
公开(公告)日：2019-05-08
申请号：EP18187522.0
申请日：2011-02-03
发明人： KAKKIS, Emil, D. , VELLARD, Michel Claude , WENDT, Daniel, J. , MUTHALIF, Mubarack , OKHAMAFE, Augustus O. , BELL, Sean M. , ZECHERLE, G. Nick , ANTONSEN, Kris , ZHANG, Yanhong , LY, Kieu Y. , FITZPATRICK, Paul A.
CPC分类号： C12N9/88 , A61K9/0019 , A61K38/51 , A61K47/60 , C07K1/14 , C12Y403/01024
摘要： Provided are compositions comprising a recombinant phenylalanine ammonia-lyase (PAL) derived from the bacterial species Anabaena variabilis, Nostoc punctiforme, Streptomyces maritimus, Streptomyces verticillatus, Soragium cellulosum, Nostoc tobacum, or Pseudomonas putida, or a biologically active fragment, mutant, variant or analog thereof, and a pharmaceutically acceptable carrier. Further provided are such compositions of recombinant bacterial PAL and biologically active fragments, mutants, variants or analogs thereof for use in treating phenylketonuria hyperphenylalaninemia.
-
公开(公告)号：EP3115372B1
公开(公告)日：2019-03-06
申请号：EP16182420.6
申请日：2013-11-27
-
公开(公告)号：EP2680694B1
公开(公告)日：2019-01-02
申请号：EP12751918.9
申请日：2012-02-28
IPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D261/08 , C07D263/32 , C07D277/30 , C07D513/04 , A61K31/16
-
76.发明公开
公开(公告)号：EP3352787A1
公开(公告)日：2018-08-01
申请号：EP16778589.8
申请日：2016-09-23
IPC分类号： A61K39/12 , C07K14/755
CPC分类号： A61K38/37 , A61K39/12 , A61K47/02 , A61K47/10 , A61K47/26 , A61K48/0008 , A61K48/0075 , C07K14/755 , C12N7/00 , C12N2710/16044 , C12N2750/14121 , C12N2750/14141 , C12N2750/14143 , G01N33/6854 , G01N2333/015
摘要： The invention provides adeno-associated virus (AAV) Factor VIII (FVIII)-encoding/expressing vectors and virus, including AAV FVIII vectors with high expression activity and AAV FVIII vectors that express full-length or truncated functional FVIII protein. The invention also relates to methods of making the herein described AAV FVIII vectors, recombinant AAV FVIII virus particles comprising or expressing such vectors, associated pharmaceutical formulations comprising the same and therapeutic uses thereof.
-
77.发明公开
公开(公告)号：EP3264080A3
公开(公告)日：2018-03-21
申请号：EP17175199.3
申请日：2009-12-31
CPC分类号： C12Q1/527 , C12Q1/34 , C12Q1/40 , G01N33/6893 , G01N2333/924 , G01N2400/00 , G01N2800/042 , G01N2800/52
摘要： Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
-
公开(公告)号：EP3268355A1
公开(公告)日：2018-01-17
申请号：EP16711941.1
申请日：2016-03-10
发明人： WANG, Bing
IPC分类号： C07D265/02 , A61K31/535 , A61P35/00
CPC分类号： C07D265/02 , C07D217/26 , C07D311/76 , C07D409/04 , C07D413/12 , C07D495/04 , C07D498/04
摘要： Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
-
79.发明公开MANUFACTURE OF ACTIVE HIGHLY PHOSPHORYLATED HUMAN LYSOSOMAL SULFATASE ENZYMES AND USES THEREOF 审中-公开活性高度磷酸化人溶酶体硫酸酯酶的制备及其应用
公开(公告)号：EP3219795A1
公开(公告)日：2017-09-20
申请号：EP16203748.5
申请日：2009-01-16
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
摘要翻译： 本发明提供了活性高度磷酸化溶酶体硫酸酯酶的组合物，它们的药物组合物，生产和纯化这种溶酶体硫酸酯酶和组合物的方法以及它们在诊断，预防或治疗疾病和病症中的用途，特别包括溶酶体贮积病 由溶酶体硫酸酯酶缺陷引起或与之相关。
-
80.发明授权COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF 有权从原核苯丙氨酸解氨，变异和方法的组合物用于其使用组合物
公开(公告)号：EP2531209B1
公开(公告)日：2016-04-20
申请号：EP11740323.8
申请日：2011-02-03
发明人： OKHAMAFE, Augustus, O. , BELL, Sean, M. , ZECHERLE, G., Nick , ANTONSEN, Kris , ZHANG, Yanhong , LY, Kieu, Y , FITZPATRICK, Paul, A. , KAKKIS, Emil, D. , VELLARD, Michel, Claude , WENDT, Daniel, J. , MUTHALIF, Mubarack
CPC分类号： C12N9/88 , A61K9/0019 , A61K38/51 , A61K47/60 , C12Y403/01024
-
-
-
-
-
-
-
-
-
搜索结果
173 条记录 (耗时 0.042 秒)
