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255 条记录 (耗时 0.014 秒)

    PURIFICATION OF 1,1,2-TRICHLOROETHANE
    71.
    发明公开
    PURIFICATION OF 1,1,2-TRICHLOROETHANE 失效
    1,1,2-三氯乙烷的纯化

    公开(公告)号：EP0700377A1

    公开(公告)日：1996-03-13

    申请号：EP94916814.0

    申请日：1994-05-25

    申请人： MALLINCKRODT MEDICAL, INC.

    发明人： MCCARTHY, William, Z.

    IPC分类号： C07C17

    CPC分类号： C07C17/38 ,  C07C19/05

    摘要： A process for the recovery and purification of 1,1,2-trichloroethane from the intermediates produced for the production of ioversol for reuse thereof.

    摘要翻译： 一种从用于生产碘佛醇制备的中间体中回收和纯化1,1,2-三氯乙烷以再利用它的方法。

    STABILIZED THERAPEUTIC RADIOPHARMACEUTICAL COMPLEXES
    74.
    发明公开
    STABILIZED THERAPEUTIC RADIOPHARMACEUTICAL COMPLEXES 失效
    稳定型治疗性药物RADIO复杂。

    公开(公告)号：EP0660722A1

    公开(公告)日：1995-07-05

    申请号：EP91915301.0

    申请日：1991-07-03

    申请人： MALLINCKRODT MEDICAL, INC.

    发明人： WOLFANGEL, Robert, F.

    IPC分类号： A61K51

    CPC分类号： A61K51/1093 ,  A61K51/1241 ,  A61K2121/00 ,  A61K2123/00

    摘要： A method of preparing a stable, therapeutic radiopharmaceutical composition comprised of an alpha- or beta-emitting radionuclide and a ligand by lyophilizing a solution of the complex. The radionuclide preferably has a half-life of at least twelve hours. The invention also is directed to stable lyophilized radiopharmaceutical compositions prepared by this method. The invention is particularly suited to the preparation of radionuclide-labeled antibodies in a stable form which merely requires reconstitution at the point of use.

    METHOD FOR PREPARING A METAL-RADIONUCLIDE-LABELLED PROTEIN
    75.
    发明公开
    METHOD FOR PREPARING A METAL-RADIONUCLIDE-LABELLED PROTEIN 失效
    的金属放射性核素标记的蛋白质的制造方法。

    公开(公告)号：EP0654043A1

    公开(公告)日：1995-05-24

    申请号：EP94915454.0

    申请日：1994-05-02

    申请人： MALLINCKRODT MEDICAL, INC.

    发明人： VERBRUGGEN, Alfons, M.

    IPC分类号： A61K39 ,  A61K51

    CPC分类号： A61K51/081 ,  A61K51/08 ,  A61K51/088 ,  A61K2121/00 ,  A61K2123/00

    摘要： The invention relates to a method of preparing a metal-radionuclide-labelled protein or proteinaceous material, which is intended for diagnostic or therapeutic application, by reacting a protein or a proteinaceous material with a bifunctional agent for coupling the radionuclide to the protein or proteinaceous material, a protein conjugate being formed by reaction between bifunctional agent and free amino groups or mercapto groups in the protein or proteinaceous material, and then complexing the radionuclide with the conjugate thus formed to a radionuclide complex. The invention further relates to the labelled protein or proteinaceous material thus obtained, and to a kit for preparing a radiopharmaceutical composition, which kit comprises the above-mentioned polyfunctional agent or a protein conjugate formed by reaction of a protein or proteinaceous material with said polyfunctional agent.

    METHOD AND KIT FOR PREPARING TECHNETIUM-99M COMPLEXES
    78.
    发明公开
    METHOD AND KIT FOR PREPARING TECHNETIUM-99M COMPLEXES 失效
    方法和试剂锝-99m制造复杂。

    公开(公告)号：EP0639082A1

    公开(公告)日：1995-02-22

    申请号：EP91909080.0

    申请日：1991-04-10

    申请人： MALLINCKRODT MEDICAL, INC. ,  VERBRUGGEN, Alfons

    发明人： VERBRUGGEN, Alfons c/o Octrooibureau Zoan B.V.

    IPC分类号： A61K51 ,  C07B59 ,  C07F13

    CPC分类号： A61K51/04 ,  A61K51/00

    摘要： The invention relates to a method of preparing a radiolabeled technetium complex by bringing together a pertechnetate solution in a complex-forming reaction with a compound of general formula (I) wherein R1-R12 independently represent H, C1-C4 alkyl, a carboxy group, or carboxy (C1-C4) alkyl; or wherein R1 + R2, R3 + R4, R5 + R6, R7 + R8, R9 + R10 and R11 + R12 independently represent an oxo or imino function; and wherein: R13 is H, C1-C4 alkyl or carboxy (C1-C4) alkyl; R14 is H or NH2; n is 0, 1 or 2; A represents NH2 or SH; and B represents SH, or a group of the general formula NH-(Z-CO-NH)-mZ-COOH; said reaction performed in the presence of Sn(II) as a reducing agent, in the absence of a transfer agent, in a substantially aqueous solvent system having a pH of at least 10, and at ambient temperature. The invention further relates to a kit for performing said method.