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公开(公告)号：EP2825209B1
公开(公告)日：2018-08-29
申请号：EP13761148.9
申请日：2013-03-13
IPC分类号： A61K48/00 , A61P35/00 , A61K31/38 , A61K31/422 , A61K31/427 , A61K31/4709 , A61K31/498 , A61K31/55
CPC分类号： A61K31/427 , A61K31/185 , A61K31/34 , A61K31/38 , A61K31/422 , A61K31/4709 , A61K31/498 , A61K31/55 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/141 , C12Y207/11001 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5058 , G01N2333/912 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a LIMK modulating agent. Also disclosed are compounds newly identified to be inhibitors of Merlin-null Schwann cell proliferation and/or survival.
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公开(公告)号：EP2951281B1
公开(公告)日：2018-06-27
申请号：EP14745661.0
申请日：2014-01-30
IPC分类号： G01N33/483 , G01N33/50
CPC分类号： G01N33/4836 , C12M21/08 , C12M41/48
摘要： In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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73.发明授权MULTIFUNCTIONAL SILICA-BASED COMPOSITIONS AND GELS, METHODS OF MAKING THEM, AND METHODS OF USING THEM 有权多功能硅石基组合物和凝胶，其制备方法和使用它们的方法
公开(公告)号：EP2552196B1
公开(公告)日：2018-05-09
申请号：EP11766455.7
申请日：2011-03-29
发明人： SANTRA, Swadeshmukul
IPC分类号： A01N25/08 , A01N25/12 , A01N59/00 , A01N31/00 , A01N25/04 , A01N25/34 , A01N59/20 , B82Y5/00 , A01N25/28
CPC分类号： B82Y5/00 , A01N25/28 , A01N25/34 , A01N59/20 , A01N25/04 , A01N59/16 , A01N25/12 , A01N31/02
摘要： Briefly described, embodiments of this disclosure, among others, include compositions, gels, methods for synthesizing multifunctional silica based nanoparticle gel, method of treating, preventing, or both treating and preventing, a disease in a plant species, method for simultaneously treating citrus plants for citrus canker and preventing the invasion of an Asian Citrus Psyllid (ACP) vector that carries the pathogen and spreads the citrus greening disease in citrus plants, and the like.
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74.发明公开COMPOSITIONS INCLUDING A VACANCY-ENGINEERED (VE)-ZNO NANOCOMPOSITE, METHODS OF MAKING THE COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS 审中-公开包括空隙工程（VE） - 氧化锌纳米复合材料的组合物，制备组合物的方法和使用组合物的方法
公开(公告)号：EP3270699A1
公开(公告)日：2018-01-24
申请号：EP16711711.8
申请日：2016-02-23
CPC分类号： A01N59/16 , A01N25/04 , A01N25/28 , A01N25/34 , A01N31/00 , A01N2300/00 , B82Y30/00 , B82Y40/00 , C01G9/02 , A01N59/00
摘要： Embodiments of the present disclosure, in one aspect, relate to compositions including a vacancy-engineered (VE)-ZnO nanocomposite, methods of making a composition, methods of using a composition, and the like.
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公开(公告)号：EP3223856A1
公开(公告)日：2017-10-04
申请号：EP15853854.6
申请日：2015-10-27
CPC分类号： A61K35/17 , A61K35/13 , A61K38/177 , A61K38/20 , A61K38/2013 , A61K2035/124 , C07K14/54 , C07K14/5434 , C07K14/55 , C07K14/70525 , C07K14/70596 , C12N5/0646 , C12N2500/84 , C12N2501/2302 , C12N2501/2321 , C12N2501/599
摘要： Disclosed herein are novel compositions and methods for stimulation of and the production or expansion of natural killer (NK) cells. Numbers of NK cells can be increased following contact with exosomes modified with one or more stimulatory peptides. Methods and compositions for the production of exosomes, wherein the exosomes comprises stimulatory peptides are also described. Also described are methods of treating cancer using the disclosed NK-stimulating exosomes or NK cells stimulated by the disclosed methods.
摘要翻译： 本文公开了用于刺激天然杀伤（NK）细胞并产生或扩增的新型组合物和方法。 在与用一种或多种刺激性肽修饰的外来体接触后，可以增加NK细胞的数量。 还描述了用于产生外来体的方法和组合物，其中外泌体包含刺激性肽。 还描述了使用公开的由所公开的方法刺激的NK刺激性外来体或NK细胞治疗癌症的方法。
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76.发明授权CARDIAC INDUCED PLURIPOTENT STEM CELLS AND METHODS OF USE IN REPAIR AND REGENERATION OF MYOCARDIUM 有权心脏病发作的诱导多能干细胞和使用过程中用于修复和再生心脏肌肉
公开(公告)号：EP2627342B1
公开(公告)日：2016-08-24
申请号：EP11833476.2
申请日：2011-10-14
发明人： SINGLA, Dinender
CPC分类号： A61K35/34 , A61K35/545 , C12N5/0657 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1315 , C12N2506/45
摘要： Cardiac myocyte differentiation reported thus far is from iPS cells generated from mice and human fibroblasts. iPS cells from cardiac or ventricular specific cell types are generated herein having the potential to repair and regenerate infarcted myocardium. The cells were transduced with four sternness factors and reprogrammed them into iPS cells. These cardiac iPS cells were able to differentiate into beating cardiac myocytes, formed cardiac-specific structures, and positively stained for cardiac specific proteins. Transplanted cells also significantly inhibited apoptosis and fibrosis and improved cardiac function.
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77.发明公开CATALYSTS FOR THE MECHANOCATALYTIC OXIDATIVE DEPOLYMERIZATION OF POLYMER-CONTAINING MATERIALS AND METHODS OF MAKING OXIDIZED REACTION PRODUCTS USING SAME 审中-公开用于含聚合物材料机械催化氧化加聚的催化剂及使用相同方法制备氧化反应产物的方法
公开(公告)号：EP2964600A1
公开(公告)日：2016-01-13
申请号：EP14759670.4
申请日：2014-03-07
CPC分类号： C07C45/61 , B01J23/002 , B01J23/10 , B01J23/34 , B01J23/83 , B01J23/8892 , B01J23/8926 , B01J27/24 , B01J2523/00 , C07C45/27 , C07C47/58 , C07C51/347 , C07C65/21 , C07C47/56
摘要： The presently disclosed and/or claimed inventive concept(s) relates generally to oxidative oxidized reaction products made from the mechanocatalytic oxidative depolymerization of lignin. More particularly, but without limitation, the mechanocatalytic oxidative depolymerization of lignin is performed in a non-aqueous/non-solvent based and solvent-free process, i.e., via a solid-solid mechanocatalytic oxidative reaction methodology. In one particular embodiment, the process of making such oxidative oxidized reaction products includes, without limitation, the step of mechanocatalytically reacting an oxidation catalyst with lignin or a lignin-containing material. The oxidative reaction products obtained from the process include, for example, at least one of vanillin, and syringealdehyde, vanillic acid, and syringic acid.
摘要翻译： 目前公开的和/或要求保护的发明构思通常涉及由木质素的机械催化氧化解聚制成的氧化氧化反应产物。 更具体但非限制性地，木质素的机械催化氧化解聚在非水/非溶剂基和无溶剂过程中进行，即通过固 - 固机械催化氧化反应方法进行。 在一个具体实施方案中，制造这种氧化氧化反应产物的方法包括但不限于使氧化催化剂与木质素或含木质素材料机械催化反应的步骤。 从该方法获得的氧化反应产物包括例如香草醛和注射醛，香草酸和丁香酸中的至少一种。
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公开(公告)号：EP2867973A1
公开(公告)日：2015-05-06
申请号：EP13808682.2
申请日：2013-06-28
发明人： MA, Mingyao , HU, Haibing , KUTKUT, Nasser , BATARSEH, Issa , SHEN, John , BKAYRAT, Raed
CPC分类号： H02J3/383 , H02M3/04 , H02M7/44 , H02M7/49 , Y02E10/563
摘要： The present invention is directed to a system configured to be connected to an AC power grid having at least one AC phase signal. The system includes at least one inverter module comprising a first inverter having a plurality of first switch elements coupled to a direct current (DC) voltage and actuated in accordance with a first set of control signals based on the at least one AC phase signal. The first inverter provides a first voltage signal having predetermined harmonic components. The at least one inverter module further comprises a second inverter including a plurality of second switch elements coupled to the DC voltage and actuated in accordance with a second set of control signals phase delayed with respect to the first set of control signals. The second switching inverter providing a second voltage signal having the predetermined harmonic components. At least one transformer module includes at least one first primary winding coupled to the first inverter and at least one second primary winding coupled to the second inverter. The transformer module further includes at least one secondary winding coupled to the at least one first primary winding, the at least one second primary winding and the AC power grid for each at least one AC phase signal. The secondary winding is configured to provide a secondary output voltage to the AC power grid by combining the first voltage signal and the second voltage signal such that the predetermined harmonic components are substantially cancelled.
摘要翻译： 本发明涉及一种被配置为连接到具有至少一个AC相位信号的交流电网的系统。 该系统包括至少一个逆变器模块，该逆变器模块包括第一逆变器，其具有耦合到直流（DC）电压的多个第一开关元件，并且基于至少一个AC相位信号根据第一组控制信号而被致动。 第一反相器提供具有预定谐波分量的第一电压信号。 所述至少一个逆变器模块还包括第二反相器，其包括耦合到所述DC电压的多个第二开关元件，并且根据相对于所述第一组控制信号延迟相位的第二组控制信号而被致动。 第二开关逆变器提供具有预定谐波分量的第二电压信号。 至少一个变压器模块包括耦合到第一逆变器的至少一个第一初级绕组和耦合到第二逆变器的至少一个第二初级绕组。 变压器模块还包括耦合到至少一个第一初级绕组，至少一个第二初级绕组和用于每个至少一个AC相位信号的AC电网的至少一个次级绕组。 次级绕组被配置为通过组合第一电压信号和第二电压信号来向AC电网提供次级输出电压，使得预定谐波分量基本上被取消。
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公开(公告)号：EP2859532A1
公开(公告)日：2015-04-15
申请号：EP13812975.4
申请日：2013-06-12
发明人： SUGAYA, Kiminobu , SUGAYA, Andrew
CPC分类号： G06T19/20 , G06F3/017 , G06F3/04842 , G06T7/254 , G06T2207/10016 , G06T2207/20224 , G06T2207/30196 , G06T2219/2016
摘要： Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
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80.发明公开ORALLY-ADMINISTERED PLASTID EXPRESSED CHOLERA TOXIN B SUBUNIT-EXENDIN 4 AS TREATMENT FOR TYPE 2 DIABETES 有权口服给药PLASTIDEXPRIMIERTES霍乱毒素B亚基，毒蜥外泌4 FOR USE IN 2型糖尿病的治疗
公开(公告)号：EP2770991A1
公开(公告)日：2014-09-03
申请号：EP12844486.6
申请日：2012-10-24
发明人： DANIELL, Henry
CPC分类号： A61K36/81 , A61K36/23 , A61K36/28 , A61K36/73 , A61K38/162 , A61K38/164 , A61K38/2278 , A61K38/26 , A61K38/51 , C07K14/195 , C07K14/605 , C07K2319/55 , Y02A50/471
摘要： Disclosed herein are compositions and methods for treating Type II diabetes. The compositions comprise plant expressed Exendin 4. Particularly exemplified are plant derived compositions that include a CTB-EX4 conjugate that is bioencapsulated in chloroplasts.
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