公开(公告)号：EP1738762A4

公开(公告)日：2009-07-08

申请号：EP05727384

申请日：2005-03-25

申请人： AJINOMOTO KK

发明人： KITAHARA YOSHIRO ,  TAKEUCHI MASAYOSHI

IPC分类号： A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  C07K5/11

CPC分类号： A61K38/07

摘要： The present invention provides a novel agent for the prophylaxis or treatment of diabetic complications. Specifically, the present invention provides an agent for the prophylaxis or treatment of diabetic complications, which contains, as an active ingredient, an oligopeptide containing at least two amino acid residues having an amino group or a guadinino group in the side chain, and which has AGE2 production inhibitory action and AGE2 blood concentration reduction promoting action.

公开(公告)号：EP2011861A4

公开(公告)日：2009-01-07

申请号：EP07741793

申请日：2007-04-17

申请人： AJINOMOTO KK

发明人： ASAHARA TAKAYUKI ,  MATSUNO KIYOSHI ,  MORI YUKIKO

CPC分类号： C12N9/1022 ,  C12P19/32 ,  C12P19/40

摘要： A purine substance can be produced by culturing a Bacillus bacterium which is capable of producing the purine substance and has a reduced enzymatic activity of transaldolase in a culture medium to produce and accumulate the purine substance in the culture medium or a cell of the bacterium, and collecting the purine substance from the culture medium or the cell.

公开(公告)号：EP1908492A4

公开(公告)日：2008-12-10

申请号：EP06767132

申请日：2006-06-22

申请人： AJINOMOTO KK

发明人： TAKESHITA SEN ,  OHSU TAKEAKI ,  ETO YUZURU ,  TAKAHASHI MITSUO

IPC分类号： A61K31/198 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/7076 ,  A61K31/708 ,  A61K33/06 ,  A61P1/00 ,  A61P1/02 ,  A61P1/14 ,  A61P1/16 ,  A61P3/04

CPC分类号： A61K31/708 ,  A61K31/185 ,  A61K31/198 ,  A61K31/401 ,  A61K31/403 ,  A61K31/405 ,  A61K31/4164 ,  A61K31/4172 ,  A61K31/7076 ,  A61K33/06 ,  G01N2333/70571 ,  A61K2300/00

摘要： A amino acid other than glutamic acid is used as a metabotropic glutamate receptor activator. More preferably, aspartic acid, valine or cysteine is used as a group I metabotropic glutamate receptor activator; alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, ornithine, taurine or hydroxyproline is used as a group II metabotropic glutamate receptor activator; and cysteine is used as a group III metabotropic glutamate receptor activator.

公开(公告)号：EP1668994A4

公开(公告)日：2008-12-03

申请号：EP04773603

申请日：2004-09-28

申请人： AJINOMOTO KK

发明人： FUKUDA AKIHIRO ,  NUMAZAWA TOSHIYA ,  IDE HIROYUKI

IPC分类号： A23L13/00 ,  A23L13/40 ,  A23L13/50 ,  A23L13/70 ,  A23L17/00 ,  A23L17/40

CPC分类号： A23L17/00 ,  A23L13/426 ,  A23L13/428 ,  A23L13/72 ,  A23V2002/00 ,  A23V2250/161 ,  A23V2250/31 ,  A23V2250/616 ,  A23V2250/5118

摘要： To develop a meat improving agent which is used in heat-cooked foods of animal and fishery products at the stage of pretreatment before heating, whereby even after storage at room temperature or under chilling or freezing for 24 hours, a soft feel, a juicy feel and a fibrous feel are maintained while keeping a yield equal to a yield given by ordinary products, and a taste is not deteriorated. A meat improving agent comprising, per part by weight of a roast salt, from 0.001 to 0.1 part by weight of glutathione, from 2.5 to 5.5 parts by weight of a sugar alcohol and from 1.0 to 2.5 parts by weight of a starch derivative obtained by esterifying or/and etherifying starch.

公开(公告)号：EP1921155A4

公开(公告)日：2008-11-05

申请号：EP06797338

申请日：2006-08-29

申请人： AJINOMOTO KK

发明人： NAKAGOSHI HIROYUKI ,  ISHIDA RIKIYA

IPC分类号： C12Q1/37 ,  A23J3/14 ,  A23L1/00 ,  A23L1/314 ,  A23L1/32 ,  A23L1/325 ,  A23L1/328 ,  C12N9/10

CPC分类号： A23J1/00 ,  A23L17/65 ,  A23L29/06 ,  C12Q1/37 ,  C12Y203/02013

摘要： Disclosed is a method for determination of protease activity in a transglutaminase-containing matter. The method comprises the steps of mixing an aqueous solution containing the transglutaminase-containing matter (a sample solution) with an aqueous dimethylcasein solution at a specific [activity of transglutaminase]:[amount of dimethylcasein] ratio, leaving the mixture to stand under specific conditions to allow the mixture to degrade by the action of the protease, adding an acid to the mixture, filtering the mixture, and determining the amount of a protein in the filtrate. The method is particularly useful for the preparation of a transglutaminase preparation for use in the food adhesion or in a fish cake.

公开(公告)号：EP1739431A4

公开(公告)日：2008-10-15

申请号：EP05733999

申请日：2005-04-25

申请人： AJINOMOTO KK

发明人： TAKATSUKI FUMIHIKO ,  UENO TAKATO ,  SATA MICHIO

IPC分类号： G01N33/92 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/92 ,  G01N2800/08 ,  Y10T436/204165

摘要： Phospholipids in the peripheral blood and the fatty acid compositions thereof are determined. In particular, the contents of phosphaditylserine/phosphatidylinositol and phosphatidylcholine in the peripheral blood and the fatty acid compositions thereof are determined. Thus, it becomes possible to provide a method of evaluating a remedy for NASH useful for NASH patients, a method of judging NASH and a remedy therefor.

公开(公告)号：EP1733631A4

公开(公告)日：2008-10-08

申请号：EP05710676

申请日：2005-02-18

申请人： AJINOMOTO KK

发明人： ISHIZAKI TAICHI ,  KURODA MOTONAKA ,  HONDA MASASHI ,  YAMADA KEIKO

IPC分类号： A23L1/305 ,  A23L1/30 ,  A23L1/325 ,  A61K35/60 ,  A61P25/00 ,  A61P25/18 ,  A61P43/00

CPC分类号： A61K35/60 ,  A23L17/00 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2200/31 ,  A23V2250/2042 ,  A23V2250/543 ,  A23V2250/0644

摘要： In this application is disclosed a food composition having an anti-stress action, which composition comprises, as an active ingredient, an extract of migratory fish or a mixture of nutritional components of a similar composition to the above-mentioned extract in an amount of 0.5 g or more per one meal of the extract or the mixture in terms of the solid content thereof. With the food composition it is possible to prevent or alleviate states such as fatigue e.g., asthenopia, mental fatigue, emotional dysfunction and the like, caused by stress and felt on a daily basis.

公开(公告)号：EP1481673A4

公开(公告)日：2008-09-24

申请号：EP03703174

申请日：2003-02-05

申请人： AJINOMOTO KK

发明人： IWAYAMA SATOSHI ,  KOGANEI HAJIME ,  FUJITA SHINICHI ,  TAKEDA TOMOKO ,  YAMAMOTO HIROSHI ,  NIWA SEIJI

IPC分类号： A61K31/195 ,  A61K31/451 ,  A61K45/00 ,  A61K45/06 ,  A61P25/04 ,  A61P43/00 ,  C07D211/70

CPC分类号： C07D211/70 ,  A61K31/195 ,  A61K31/451 ,  A61K45/06 ,  A61K2300/00

摘要： Medicinal compositions useful as preventives/remedies for pain which comprise gabapentin, pregabalin or pharmaceutically acceptable salts thereof combined with N-type calcium channel antagonists or pharmaceutically acceptable salts thereof, for example, a compound having the following structure.

公开(公告)号：EP1829968A4

公开(公告)日：2008-09-10

申请号：EP05820283

申请日：2005-12-20

申请人： AJINOMOTO KK

发明人： ABE ISAO ,  TAKESHITA RIE ,  HARA SEIICHI ,  SUZUKI SONOKO ,  YOKOZEKI KENZO ,  SUGIYAMA MASAKAZU ,  SUZUKI SHUNICHI ,  WATANABE KUNIHIKO ,  SHIMBA NOBUHISA ,  NAKAMURA TAKEFUMI ,  TAGAMI UNO ,  KODAMA YUYA ,  ONOYE HIROMI ,  YUUJI REIKO ,  SUZUKI EIICHIRO ,  KASHIWAGI TATSUKI ,  XU NINGCHUN ,  KAI YUKO

IPC分类号： C12N15/09 ,  C12N9/00 ,  C12P13/00 ,  C12P21/02

CPC分类号： C07K14/00 ,  C07K14/195 ,  C12N9/93

摘要： Disclosed is an excellent peptide-producing protein. Also disclosed is a process for producing a peptide with high efficiency, or the like. The process comprises reacting an amine component with a carboxy component in the presence of at least one of the following proteins (I) and (II) to produce a peptide: (I) a mutant protein comprising an amino acid sequence having one or more of the mutations shown in mutation types 1 to 68, 239 to 290 and 324 to 377 in the amino acid sequence depicted in SEQ ID NO: 2; and (II) a mutant protein comprising an amino acid sequence having one or more of the mutations shown in mutation types L1 to L335 and M1 to M642 in the amino acid sequence depicted in SEQ ID NO: 208.

公开(公告)号：EP1626044A4

公开(公告)日：2008-08-20

申请号：EP04733967

申请日：2004-05-19

申请人： AJINOMOTO KK

发明人： MAKINO SHINGO ,  FUKUCHI NAOYUKI ,  ASARI SAYAKA ,  HASHIMOTO MASAKI ,  YANO TETSUO ,  YAMADA YOUJI ,  TOKUMASU MUNETAKA ,  SHOJI MASATAKA ,  TANABE ITSUYA ,  FUJITA SHINICHI ,  MATSUMOTO HIDEKI

IPC分类号： C07D211/70 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61P1/06 ,  A61P1/10 ,  A61P1/12 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12

CPC分类号： C07D211/70

摘要： A piperidine derivative of the following formula that is useful as a preventive or therapeutic agent for various diseases in which 5-HT7 takes part, or homologues thereof.