ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES
    75.
    发明授权
    ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES 有权
    敏感液体成分在基质中的封闭获得离散稳定粒子

    公开(公告)号:EP1119345B1

    公开(公告)日:2009-04-29

    申请号:EP99951433.4

    申请日:1999-10-06

    摘要: A liquid encapsulant component which contains an active, sensitive encapsulant, such as a live microorganism or an enzyme dissolved or dispersed in a liquid plasticizer is admixed with a plasticizable matrix material. The matrix material is plasticizable by the liquid plasticizer and the encapsulation of the active encapsulant is accomplished at a low temperature and under low shear conditions. The active component is encapsulated and/or embedded in the plasticizable matrix component or material in a continuous process to produce discrete, solid particles. The liquid content of the liquid encapsulant component provides substantially all or completely all of the liquid plasticizer needed to plasticize the matrix component to obtain a formable, extrudable, cuttable, mixture or dough. Removal of liquid plasticizer prior to extrusion is not needed to adjust the viscosity of the mixture for formability. Release of an active component from the matrix may be delayed or controlled over time so that the active component is delivered when and where it is needed to perform its intended function. Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or nutritionally active component are continuously produced without substantial destruction of the matrix material or encapsulant.

    摘要翻译: 含有溶解或分散在液体增塑剂中的活性敏感包封剂(例如活微生物或酶)的液体包封剂组分与可塑性基质材料混合。 基质材料可通过液体增塑剂塑化,并且活性密封剂的封装在低温和低剪切条件下完成。 活性组分被封装和/或嵌入可塑化基体组分或材料中以连续过程产生不连续的固体颗粒。 液体密封剂组分的液体含量提供基本上全部或完全全部增塑基质组分所需的液体增塑剂,以获得可成形的,可挤出的,可切割的,混合物或面团。 在挤出之前除去液体增塑剂不需要调节混合物的可成形性的粘度。 从矩阵中释放有源组件可能会随着时间的推移而被延迟或控制,以便在需要执行其预期功能的时间和地点交付有源组件。 包含包封和/或嵌入组分的控制释放的不连续的固体颗粒,如热敏或易于氧化的药学,生物学或营养学活性组分连续生产而基本上不破坏基质材料或包封剂。

    METHOD OF MAKING COMPLEXED FAT COMPOSITIONS
    77.
    发明公开
    METHOD OF MAKING COMPLEXED FAT COMPOSITIONS 审中-公开
    用于生产复合润滑脂组合

    公开(公告)号:EP1973414A2

    公开(公告)日:2008-10-01

    申请号:EP06849252.9

    申请日:2006-12-14

    IPC分类号: A23D7/005

    CPC分类号: A23D7/005

    摘要: A process of preparing a complexed fat composition in a continuous process is provided. The process comprises mixing a cyclodextrin with a solvent in an in-line mixing system at a temperature of from about 180 to about 200°F (82.2 to about 93.3°C), thereby solubilizing the cyclodextrin; mixing fat and the solubilized cyclodextrin in a static mixer mixing system at a temperature of from about 80 to about 120°F (26.7 to about 48.9°C) to form a fat/cyclodextrin composition comprising a fat/cyclodextrin complex; and cooling the fat/cyclodextrin composition in an in-line mixing system. The described continuous process is a very efficient manner of complexing fat with cyclodextrin, and provides compositions that exhibit excellent uniformity and homogeneity.