公开(公告)号：EP1432808B1

公开(公告)日：2011-05-11

申请号：EP02763110.0

申请日：2002-10-04

申请人： H1 H4 Holding B.V.

发明人： VAN HERPEN, Marinus, Maria, Antonius ,  HULZINK, Jozef, Maurinus, Raymond ,  CROES, Anton, Felix

IPC分类号： C12N15/67

CPC分类号： C12N15/8261 ,  C12N15/8216 ,  C12N15/8231 ,  C12N15/8234 ,  C12N15/8257

摘要： The present invention pertains to a method of expressing a protein of interest, preferably a heterologous protein, in preferably a plant. In a preferred embodiment said plant is a doubled haploid homozygous transgenic Nicotiana tabacum plant silenced for Ntp303. Furthermore, the invention relates to said plant with or without nucleic acid constructs according to the invention. Propagation, harvest and tissue material of said transgenic Nicotiana tabacum plant is also a part of the invention.

公开(公告)号：EP2306807A1

公开(公告)日：2011-04-13

申请号：EP09773072.5

申请日：2009-06-30

申请人： ORF Liftaekni HF.

发明人： ORVAR, Bjorn Larus ,  MANTYLA, Einar

IPC分类号： A01G31/04 ,  C12N15/82

CPC分类号： C12N15/8257 ,  A01H5/02

摘要： The present invention provides improved methods for animal-free protein production of high-value heterologous proteins produced in plants, plant derived tissue or plant cells. The invention reduces costs and increases the speed of manufacturing of active ingredients in transgenic plants. Furthermore, the invention improves the quality and safety of heterologous proteins produced in plants. The enhanced control of conditions in manufacturing of heterologous industrial and biopharmaceutical heterologous proteins obtained by the present invention with the combination of soil-less, hydroponic culture on conveyor belts with distinct nutrient zones in soilless greenhouses improves greatly the consistency of protein production in transgenic plants and conformity with quality control procedures applied for the manufacturing of active ingredients by the pharmaceutical industry, cosmetic industry, fine chemicals industry and veterinary industry.

公开(公告)号：EP2268128A4

公开(公告)日：2011-03-30

申请号：EP09718439

申请日：2009-03-06

申请人： TASMANIAN ALKALOIDS PTY LTD

发明人： FIST ANTHONY J

IPC分类号： A01H1/06 ,  A01H1/04 ,  A01H5/04 ,  A01H5/10

CPC分类号： C12N15/8257 ,  A01H1/06 ,  A01H5/00 ,  A01H5/02 ,  C07D489/02

摘要： The present invention is directed to an improved poppy straw, concentrate of poppy straw and opium of Papaver somniferum for the production of thebaine containing little or no oripavine, codeine or morphine. The present invention also provides plants, stands and seeds of Papaver somniferum and methods for the production of thebaine.

公开(公告)号：EP2297194A1

公开(公告)日：2011-03-23

申请号：EP09741822.2

申请日：2009-04-25

申请人： Westfälische Wilhelms-Universität Münster

发明人： VON SCHAEWEN, Antje ,  KAULFÜRST-SOBOLL, Heidi

IPC分类号： C07K14/47 ,  C12N15/82 ,  C12P21/00 ,  A61K38/17

CPC分类号： C12P21/005 ,  C12N9/1051 ,  C12N9/2402 ,  C12N15/8257 ,  C12N15/8258 ,  C12Y204/01065 ,  C12Y302/01045 ,  C12Y302/01114

摘要： The present invention relates to a method of generating hypoallergenic glycoproteins in mutated or transgenic plants, parts of these plants, or plant cells produced therefrom, and also to the corresponding mutated or transgenic plants, plant parts and plant cells, in which the activity of the enzyme Golgi α-mannosidase II is eliminated or reduced, and which produce hypoallergenic heterologous glycoproteins.

公开(公告)号：EP2294930A2

公开(公告)日：2011-03-16

申请号：EP10180883.0

申请日：2002-02-14

申请人： Ventria Bioscience

发明人： Huang, Ning ,  Rodriguez, Raymond, L. ,  Hagie, Frank, E.

IPC分类号： A23L1/09 ,  A23L1/10 ,  A23L1/105 ,  A23L1/185 ,  A01H5/10 ,  C12N15/82

CPC分类号： C12N9/0065 ,  A23L7/198 ,  A23L7/20 ,  A23L33/105 ,  A23L33/19 ,  A23V2002/00 ,  C07K14/485 ,  C07K14/65 ,  C07K14/79 ,  C07K14/8125 ,  C12N9/2462 ,  C12N15/8257 ,  A23V2300/21

摘要： The invention is directed to food and food additive compositions comprising one or more human milk proteins produced in the seeds of a trangenic plant and methods of making the same. The invention is further directed to improved infant formula comprising such food supplement composition.

摘要翻译： 本发明涉及包含在转基因植物的种子中产生的一种或多种人乳蛋白质的食品和食品添加剂组合物及其制备方法。 本发明进一步涉及包含这种食物补充剂组合物的改进的婴儿配方奶粉。

公开(公告)号：EP2220105A4

公开(公告)日：2011-01-19

申请号：EP08738278

申请日：2008-04-30

申请人： PROTALIX LTD

发明人： SHAALTIEL YOSEPH ,  BAUM GIDEON ,  BARTFELD DANIEL ,  HASHMUELI SHARON ,  LEWKOWICZ AYALA

IPC分类号： C07H21/04 ,  C07K14/00 ,  C12M1/00 ,  C12N20060101 ,  C12N9/24 ,  C12N15/82 ,  C12P21/00

CPC分类号： A61K38/47 ,  A61K9/0053 ,  A61K36/23 ,  C07K2319/04 ,  C12N9/2405 ,  C12N9/2434 ,  C12N9/2465 ,  C12N15/8257 ,  C12P21/005 ,  C12Y302/01022 ,  C12Y302/01045

公开(公告)号：EP2220125A4

公开(公告)日：2010-12-29

申请号：EP08848913

申请日：2008-11-12

申请人： SAPPHIRE ENERGY INC

发明人： HEIFETZ PETER B ,  FRANKLIN SCOTT E

IPC分类号： C07K19/00 ,  C07K16/00 ,  C12N1/00 ,  C12N1/12 ,  C12N15/62

CPC分类号： C12N15/8257 ,  C12N15/8258

公开(公告)号：EP2256189A1

公开(公告)日：2010-12-01

申请号：EP10174310.2

申请日：2004-03-26

申请人： NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES ,  NIPPON PAPER INDUSTRIES CO., LTD. ,  SANWA KAGAKU KENKYUSHO CO., LTD.

发明人： Sugita, Koichi ,  Kasahara, Saori ,  Ebinuma, Hiroyasu ,  Takaiwa, Humio ,  Jomori, Takahito ,  Hayashi, Yuji ,  Tashita, Akira ,  Kobara, Yukari

IPC分类号： C12N15/00 ,  A01H5/00 ,  C07K14/605

CPC分类号： C12N15/8257 ,  C07K14/605 ,  C12N15/8216

摘要： The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the oytohinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided.

摘要翻译： 本发明提供了在植物贮藏器官和GLP-1衍生物中高度产生重组蛋白的方法。 通过使用包含重组蛋白基因，细胞分裂素相关基因，耐药性基因和可除去DNA元件的载体转化获得重组蛋白高度产生的植物贮藏器官，其中奥托列宁 相关基因和耐药基因存在于与DNA元件一起表现的位置，而在植物储存器官中表达的重组蛋白存在于与DNA不一致的位置 元件。 通过使用该方法制备GLP-1，进一步提供了稳定的酶消化衍生物。

公开(公告)号：EP2250271A2

公开(公告)日：2010-11-17

申请号：EP09713417.5

申请日：2009-02-18

申请人： Norfolk Plant Sciences Limited

发明人： LUO, Jie ,  BUTELLI, Eugenio ,  JONES, Jonathan ,  TOMLINSON, Laurence ,  MARTIN, Catherine, Rosemary

IPC分类号： C12N15/82

CPC分类号： C12N15/8257 ,  C07K14/415 ,  C07K14/4702 ,  C12N15/8201 ,  C12N15/825

摘要： The invention provides methods, compositions and transformation systems for modifying the levels of transcription factors in plants such as Solanaceous plants, and introducing disease resistance genes into plants, to produce products with elevated levels of antioxidant compounds, including but not limited to flavonols and chlorogenic acid, as well as exhibiting enhanced disease resistance, and optionally altered appearance. Preferred plants are those in which introduced genes are from Solanaceous species.

公开(公告)号：EP2240589A1

公开(公告)日：2010-10-20

申请号：EP09700649.8

申请日：2009-01-08

申请人： Plant Bioscience Limited

发明人： SAINSBURY, Frank ,  LOMONOSSOFF, George, Peter

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N15/8216 ,  C12N15/8203 ,  C12N15/8257 ,  C12N15/8258

摘要： The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the 'hyper-translatable' Cowpea Mosaic Virus ('CPMV-HT') based protein expression system.